Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000300010 |
Resumo: | Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confidence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG < 21 vs. CAG > 21 and CAG < 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians. |
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International Braz J Urol (Online) |
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Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian populationReceptors, AdrenergicPolymorphism, Genetic;Benign Prostatic HyperplasiaBenign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confidence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG < 21 vs. CAG > 21 and CAG < 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians.Sociedade Brasileira de Urologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000300010International braz j urol v.38 n.3 2012reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-55382012000300010info:eu-repo/semantics/openAccessBiolchi,VanderleiSilva Neto,BrasilKoff,WalterBrum,Ilma Simonieng2012-07-20T00:00:00Zoai:scielo:S1677-55382012000300010Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2012-07-20T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
spellingShingle |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population Biolchi,Vanderlei Receptors, Adrenergic Polymorphism, Genetic; Benign Prostatic Hyperplasia |
title_short |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_full |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_fullStr |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_full_unstemmed |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_sort |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
author |
Biolchi,Vanderlei |
author_facet |
Biolchi,Vanderlei Silva Neto,Brasil Koff,Walter Brum,Ilma Simoni |
author_role |
author |
author2 |
Silva Neto,Brasil Koff,Walter Brum,Ilma Simoni |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Biolchi,Vanderlei Silva Neto,Brasil Koff,Walter Brum,Ilma Simoni |
dc.subject.por.fl_str_mv |
Receptors, Adrenergic Polymorphism, Genetic; Benign Prostatic Hyperplasia |
topic |
Receptors, Adrenergic Polymorphism, Genetic; Benign Prostatic Hyperplasia |
description |
Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confidence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG < 21 vs. CAG > 21 and CAG < 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000300010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000300010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1677-55382012000300010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.38 n.3 2012 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
_version_ |
1750318072759058432 |