Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601148 |
Resumo: | Purpose: To analyze the interaction between the cellulose exopolysaccharide (CEC) and urethral tissue when used as a pubovaginal sling. Materials and Methods: Forty Wistar rats were divided into four groups. In groups A and B the cellulose exopolysaccharide (CEC) was implanted around the urethral tissue (bladder neck below the upper margin) and the rats were sacrificed at 30 and 90 days. Similar procedure was used in groups C and D using a polypropylene mesh. After sacrifice bladder and urethra were sent for histological analysis. The histological parameters (inflammatory reaction) by evaluated by quantitative analysis. For collagen deposition analysis it was used stereological method. Results: The cellulose exopolysaccharide (CEC) was inert and well preserved at the implanted region at the time of examination. Morphologic alterations were not found at the CEC implant but some reactions of foreign body type were observed at the adjacent structures. In some areas a process of neovascular formation was observed. Stereological analysis at the suburethral area showed a significant difference in collagen presence in favor of CEC. Conclusions: The CEC implant showed adequate results when used as a suburethral sling with good integration to the host tissue, preserving its architecture. |
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International Braz J Urol (Online) |
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Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinenceSuburethral SlingsUrinary IncontinenceCelluloseBiopolymers Purpose: To analyze the interaction between the cellulose exopolysaccharide (CEC) and urethral tissue when used as a pubovaginal sling. Materials and Methods: Forty Wistar rats were divided into four groups. In groups A and B the cellulose exopolysaccharide (CEC) was implanted around the urethral tissue (bladder neck below the upper margin) and the rats were sacrificed at 30 and 90 days. Similar procedure was used in groups C and D using a polypropylene mesh. After sacrifice bladder and urethra were sent for histological analysis. The histological parameters (inflammatory reaction) by evaluated by quantitative analysis. For collagen deposition analysis it was used stereological method. Results: The cellulose exopolysaccharide (CEC) was inert and well preserved at the implanted region at the time of examination. Morphologic alterations were not found at the CEC implant but some reactions of foreign body type were observed at the adjacent structures. In some areas a process of neovascular formation was observed. Stereological analysis at the suburethral area showed a significant difference in collagen presence in favor of CEC. Conclusions: The CEC implant showed adequate results when used as a suburethral sling with good integration to the host tissue, preserving its architecture.Sociedade Brasileira de Urologia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601148International braz j urol v.41 n.6 2015reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-5538.IBJU.2014.0155info:eu-repo/semantics/openAccessLucena,Roberto G.Lima,Salvador V. C.Aguiar,José L. de A.Andrade,Rogerson T.Pinto,Flávia C. M.Vilar,Fabio O.eng2016-01-13T00:00:00Zoai:scielo:S1677-55382015000601148Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2016-01-13T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
title |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
spellingShingle |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence Lucena,Roberto G. Suburethral Slings Urinary Incontinence Cellulose Biopolymers |
title_short |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
title_full |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
title_fullStr |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
title_full_unstemmed |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
title_sort |
Experimental use of a cellulosic biopolymer as a new material for suburethral sling in the treatment of stress urinary incontinence |
author |
Lucena,Roberto G. |
author_facet |
Lucena,Roberto G. Lima,Salvador V. C. Aguiar,José L. de A. Andrade,Rogerson T. Pinto,Flávia C. M. Vilar,Fabio O. |
author_role |
author |
author2 |
Lima,Salvador V. C. Aguiar,José L. de A. Andrade,Rogerson T. Pinto,Flávia C. M. Vilar,Fabio O. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lucena,Roberto G. Lima,Salvador V. C. Aguiar,José L. de A. Andrade,Rogerson T. Pinto,Flávia C. M. Vilar,Fabio O. |
dc.subject.por.fl_str_mv |
Suburethral Slings Urinary Incontinence Cellulose Biopolymers |
topic |
Suburethral Slings Urinary Incontinence Cellulose Biopolymers |
description |
Purpose: To analyze the interaction between the cellulose exopolysaccharide (CEC) and urethral tissue when used as a pubovaginal sling. Materials and Methods: Forty Wistar rats were divided into four groups. In groups A and B the cellulose exopolysaccharide (CEC) was implanted around the urethral tissue (bladder neck below the upper margin) and the rats were sacrificed at 30 and 90 days. Similar procedure was used in groups C and D using a polypropylene mesh. After sacrifice bladder and urethra were sent for histological analysis. The histological parameters (inflammatory reaction) by evaluated by quantitative analysis. For collagen deposition analysis it was used stereological method. Results: The cellulose exopolysaccharide (CEC) was inert and well preserved at the implanted region at the time of examination. Morphologic alterations were not found at the CEC implant but some reactions of foreign body type were observed at the adjacent structures. In some areas a process of neovascular formation was observed. Stereological analysis at the suburethral area showed a significant difference in collagen presence in favor of CEC. Conclusions: The CEC implant showed adequate results when used as a suburethral sling with good integration to the host tissue, preserving its architecture. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601148 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601148 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1677-5538.IBJU.2014.0155 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.41 n.6 2015 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
_version_ |
1750318074530103296 |