Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site

Detalhes bibliográficos
Autor(a) principal: Castro,Marcos A.
Data de Publicação: 2006
Outros Autores: Ferreira,Ubirajara, Martins,Mario H., Stoppiglia,Rafael M., Rodrigues Netto Jr.,N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000200017
Resumo: OBJECTIVE: The incorporation of bowel segments for urinary tract reconstruction may induce intestinal mucosal changes with the development of metabolic, nutritional, gastrointestinal and carcinogenic complications. The early histological and histochemical changes of the intestinal mucosa in contact with the feces-urine mixture, are evaluated in the present study. MATERIALS AND METHODS: Twelve rats (operated group) were submitted to a vesico-colonic anastomosis, and 10 rats (control group) underwent a sham operation (the colon was opened and immediately sutured). On the operated group, the left colon was divided into 3 equal portions and the middle segment was used for the bladder-colonic anastomosis. After 20 weeks, the animals were sacrificed and the entire left colon in each group, as well as the bladder and the vesico-colonic anastomosis in the operated group, was removed. The proximal, middle (anastomotic site in the operated group and sutured portion in the control group) and distal colon were used for histological and histochemical studies. RESULTS: Metaplasia, chronic inflammatory process and fibrosis were significantly greater at the anastomotic site compared to the middle segment of the control group. There were no differences in both groups in terms of dysplasia, atrophy and hypertrophy either on the proximal, middle or anastomotic area and distal portion of the left colon. All animals in the operated group showed a reduced presence of sulfomucin and an increase in the sialomucin content. CONCLUSION: The histological changes observed in this study may suggest a precancerous phenomenon.
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spelling Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic siteurinary diversioncolonic urinary reservoirsmucinscarcinogensratsOBJECTIVE: The incorporation of bowel segments for urinary tract reconstruction may induce intestinal mucosal changes with the development of metabolic, nutritional, gastrointestinal and carcinogenic complications. The early histological and histochemical changes of the intestinal mucosa in contact with the feces-urine mixture, are evaluated in the present study. MATERIALS AND METHODS: Twelve rats (operated group) were submitted to a vesico-colonic anastomosis, and 10 rats (control group) underwent a sham operation (the colon was opened and immediately sutured). On the operated group, the left colon was divided into 3 equal portions and the middle segment was used for the bladder-colonic anastomosis. After 20 weeks, the animals were sacrificed and the entire left colon in each group, as well as the bladder and the vesico-colonic anastomosis in the operated group, was removed. The proximal, middle (anastomotic site in the operated group and sutured portion in the control group) and distal colon were used for histological and histochemical studies. RESULTS: Metaplasia, chronic inflammatory process and fibrosis were significantly greater at the anastomotic site compared to the middle segment of the control group. There were no differences in both groups in terms of dysplasia, atrophy and hypertrophy either on the proximal, middle or anastomotic area and distal portion of the left colon. All animals in the operated group showed a reduced presence of sulfomucin and an increase in the sialomucin content. CONCLUSION: The histological changes observed in this study may suggest a precancerous phenomenon.Sociedade Brasileira de Urologia2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000200017International braz j urol v.32 n.2 2006reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-55382006000200017info:eu-repo/semantics/openAccessCastro,Marcos A.Ferreira,UbirajaraMartins,Mario H.Stoppiglia,Rafael M.Rodrigues Netto Jr.,N.eng2006-06-08T00:00:00Zoai:scielo:S1677-55382006000200017Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2006-06-08T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
title Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
spellingShingle Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
Castro,Marcos A.
urinary diversion
colonic urinary reservoirs
mucins
carcinogens
rats
title_short Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
title_full Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
title_fullStr Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
title_full_unstemmed Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
title_sort Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site
author Castro,Marcos A.
author_facet Castro,Marcos A.
Ferreira,Ubirajara
Martins,Mario H.
Stoppiglia,Rafael M.
Rodrigues Netto Jr.,N.
author_role author
author2 Ferreira,Ubirajara
Martins,Mario H.
Stoppiglia,Rafael M.
Rodrigues Netto Jr.,N.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Castro,Marcos A.
Ferreira,Ubirajara
Martins,Mario H.
Stoppiglia,Rafael M.
Rodrigues Netto Jr.,N.
dc.subject.por.fl_str_mv urinary diversion
colonic urinary reservoirs
mucins
carcinogens
rats
topic urinary diversion
colonic urinary reservoirs
mucins
carcinogens
rats
description OBJECTIVE: The incorporation of bowel segments for urinary tract reconstruction may induce intestinal mucosal changes with the development of metabolic, nutritional, gastrointestinal and carcinogenic complications. The early histological and histochemical changes of the intestinal mucosa in contact with the feces-urine mixture, are evaluated in the present study. MATERIALS AND METHODS: Twelve rats (operated group) were submitted to a vesico-colonic anastomosis, and 10 rats (control group) underwent a sham operation (the colon was opened and immediately sutured). On the operated group, the left colon was divided into 3 equal portions and the middle segment was used for the bladder-colonic anastomosis. After 20 weeks, the animals were sacrificed and the entire left colon in each group, as well as the bladder and the vesico-colonic anastomosis in the operated group, was removed. The proximal, middle (anastomotic site in the operated group and sutured portion in the control group) and distal colon were used for histological and histochemical studies. RESULTS: Metaplasia, chronic inflammatory process and fibrosis were significantly greater at the anastomotic site compared to the middle segment of the control group. There were no differences in both groups in terms of dysplasia, atrophy and hypertrophy either on the proximal, middle or anastomotic area and distal portion of the left colon. All animals in the operated group showed a reduced presence of sulfomucin and an increase in the sialomucin content. CONCLUSION: The histological changes observed in this study may suggest a precancerous phenomenon.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000200017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000200017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1677-55382006000200017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.32 n.2 2006
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
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instname_str Sociedade Brasileira de Urologia (SBU)
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reponame_str International Braz J Urol (Online)
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repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
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