Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006 |
Resumo: | OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ± 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered. |
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Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomybladder neoplasmstransitional cellcystectomyprognosisOBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ± 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered.Sociedade Brasileira de Urologia2006-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006International braz j urol v.32 n.1 2006reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-55382006000100006info:eu-repo/semantics/openAccessAntunes,Alberto A.Nesrallah,Luciano J.Dall'Oglio,Marcos F.Ferreira,Yuri A.Passerotti,Carlo C.Leite,Katia R.Ortiz,ValdemarSrougi,Migueleng2006-06-01T00:00:00Zoai:scielo:S1677-55382006000100006Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2006-06-01T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
title |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
spellingShingle |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy Antunes,Alberto A. bladder neoplasms transitional cell cystectomy prognosis |
title_short |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
title_full |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
title_fullStr |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
title_full_unstemmed |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
title_sort |
Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
author |
Antunes,Alberto A. |
author_facet |
Antunes,Alberto A. Nesrallah,Luciano J. Dall'Oglio,Marcos F. Ferreira,Yuri A. Passerotti,Carlo C. Leite,Katia R. Ortiz,Valdemar Srougi,Miguel |
author_role |
author |
author2 |
Nesrallah,Luciano J. Dall'Oglio,Marcos F. Ferreira,Yuri A. Passerotti,Carlo C. Leite,Katia R. Ortiz,Valdemar Srougi,Miguel |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes,Alberto A. Nesrallah,Luciano J. Dall'Oglio,Marcos F. Ferreira,Yuri A. Passerotti,Carlo C. Leite,Katia R. Ortiz,Valdemar Srougi,Miguel |
dc.subject.por.fl_str_mv |
bladder neoplasms transitional cell cystectomy prognosis |
topic |
bladder neoplasms transitional cell cystectomy prognosis |
description |
OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ± 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1677-55382006000100006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.32 n.1 2006 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
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1750318069462335488 |