The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy

Detalhes bibliográficos
Autor(a) principal: Huang,Wei-Hsuan
Data de Publicação: 2017
Outros Autores: Chang,Chao-Hsiang, Huang,Chi-Ping, Wu,Hsi-Chin, Hsieh,Po-Fan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000100080
Resumo: ABSTRACT Purpose The percentage of parenchyma preserved plays a predominant role in predicting renal function after partial nephrectomy (PN). Currently there is no standard method to estimate preserved renal parenchyma. In this study we propose a formula of the percentage of resected and ischemic volume (PRAIV) determined by a geometric model and evaluate the relationships between renal functional change and PRAIV as well as other clinical parameters. Materials and Methods We identified 71 patients who underwent open PN between January 2004 and April 2014. Assuming the kidney to be an ellipsoid with bilaterally equal volume and tumor to be a sphere, we calculated PRAIV by integral calculus. Nadir estimated glomerular filtration rate (eGFR) between postoperative 3 and 12 months were recorded. The correlation between percent eGFR reduction, PRAIV, and other clinical parameters were examined. Results On univariate analysis, age (p=0.03), depth of tumor invasion (p=0.004), C index (p=0.003), RAIV (p=0.04), and PRAIV (p<0.001) were correlated with percent reduction of eGFR. However, only age (p=0.007) and PRAIV (p<0.001) were significantly correlated with percent reduction of eGFR on multivariate analysis. Depicting these values along the regression line, we found R2 was 0.194 and 0.073 for PRAIV and age, respectively. Conclusions PRAIV determined by a geometric model is a significant predictor of renal functional change after PN. Using PRAIV, we can estimate percent eGFR reduction preoperatively for better patient consultation and surgical planning.
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spelling The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomyNephrectomyDelayed Graft FunctionKidney NeoplasmsABSTRACT Purpose The percentage of parenchyma preserved plays a predominant role in predicting renal function after partial nephrectomy (PN). Currently there is no standard method to estimate preserved renal parenchyma. In this study we propose a formula of the percentage of resected and ischemic volume (PRAIV) determined by a geometric model and evaluate the relationships between renal functional change and PRAIV as well as other clinical parameters. Materials and Methods We identified 71 patients who underwent open PN between January 2004 and April 2014. Assuming the kidney to be an ellipsoid with bilaterally equal volume and tumor to be a sphere, we calculated PRAIV by integral calculus. Nadir estimated glomerular filtration rate (eGFR) between postoperative 3 and 12 months were recorded. The correlation between percent eGFR reduction, PRAIV, and other clinical parameters were examined. Results On univariate analysis, age (p=0.03), depth of tumor invasion (p=0.004), C index (p=0.003), RAIV (p=0.04), and PRAIV (p<0.001) were correlated with percent reduction of eGFR. However, only age (p=0.007) and PRAIV (p<0.001) were significantly correlated with percent reduction of eGFR on multivariate analysis. Depicting these values along the regression line, we found R2 was 0.194 and 0.073 for PRAIV and age, respectively. Conclusions PRAIV determined by a geometric model is a significant predictor of renal functional change after PN. Using PRAIV, we can estimate percent eGFR reduction preoperatively for better patient consultation and surgical planning.Sociedade Brasileira de Urologia2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000100080International braz j urol v.43 n.1 2017reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2015.0423info:eu-repo/semantics/openAccessHuang,Wei-HsuanChang,Chao-HsiangHuang,Chi-PingWu,Hsi-ChinHsieh,Po-Faneng2017-02-07T00:00:00Zoai:scielo:S1677-55382017000100080Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2017-02-07T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
title The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
spellingShingle The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
Huang,Wei-Hsuan
Nephrectomy
Delayed Graft Function
Kidney Neoplasms
title_short The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
title_full The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
title_fullStr The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
title_full_unstemmed The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
title_sort The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
author Huang,Wei-Hsuan
author_facet Huang,Wei-Hsuan
Chang,Chao-Hsiang
Huang,Chi-Ping
Wu,Hsi-Chin
Hsieh,Po-Fan
author_role author
author2 Chang,Chao-Hsiang
Huang,Chi-Ping
Wu,Hsi-Chin
Hsieh,Po-Fan
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Huang,Wei-Hsuan
Chang,Chao-Hsiang
Huang,Chi-Ping
Wu,Hsi-Chin
Hsieh,Po-Fan
dc.subject.por.fl_str_mv Nephrectomy
Delayed Graft Function
Kidney Neoplasms
topic Nephrectomy
Delayed Graft Function
Kidney Neoplasms
description ABSTRACT Purpose The percentage of parenchyma preserved plays a predominant role in predicting renal function after partial nephrectomy (PN). Currently there is no standard method to estimate preserved renal parenchyma. In this study we propose a formula of the percentage of resected and ischemic volume (PRAIV) determined by a geometric model and evaluate the relationships between renal functional change and PRAIV as well as other clinical parameters. Materials and Methods We identified 71 patients who underwent open PN between January 2004 and April 2014. Assuming the kidney to be an ellipsoid with bilaterally equal volume and tumor to be a sphere, we calculated PRAIV by integral calculus. Nadir estimated glomerular filtration rate (eGFR) between postoperative 3 and 12 months were recorded. The correlation between percent eGFR reduction, PRAIV, and other clinical parameters were examined. Results On univariate analysis, age (p=0.03), depth of tumor invasion (p=0.004), C index (p=0.003), RAIV (p=0.04), and PRAIV (p<0.001) were correlated with percent reduction of eGFR. However, only age (p=0.007) and PRAIV (p<0.001) were significantly correlated with percent reduction of eGFR on multivariate analysis. Depicting these values along the regression line, we found R2 was 0.194 and 0.073 for PRAIV and age, respectively. Conclusions PRAIV determined by a geometric model is a significant predictor of renal functional change after PN. Using PRAIV, we can estimate percent eGFR reduction preoperatively for better patient consultation and surgical planning.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/s1677-5538.ibju.2015.0423
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.43 n.1 2017
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
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