Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer

Detalhes bibliográficos
Autor(a) principal: Dall'Oglio,Marcos F.
Data de Publicação: 2006
Outros Autores: Barreto,Francualdo, Paranhos,Mario, Nesrallah,Adriano, Nesrallah,Luciano, Srougi,Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000500007
Resumo: OBJECTIVES: The treatment of recurrent prostate cancer after radiotherapy or brachytherapy through radical prostatectomy has been little indicated due to the concern over the procedure's morbidity. We present the experience of our service with postradiotherapy radical prostatectomy. MATERIALS AND METHODS: Between 1996 and 2002, 9 patients submitted to radiotherapy due to prostate cancer were treated with salvage surgery for locally recurrent disease. All patients had a biopsy of the prostate confirming the tumor recurrence, increase in the PSA levels and staging without evidence of a systemic disease. We have assessed the morbidity and the recurrence-free survival rate after salvage radical prostatectomy. RESULTS: Preradiotherapy PSA varied from 6.2 to 50 ng/mL (mean 17.3) and clinical staging T1, T2 and T3 in 33.3%, 44.4% and 22.2% of the patients respectively. The interval for the biopsy after conforming external beam radiotherapy or brachytherapy varied from 8 to 108 months (median: 36). Four patients received antiandrogenic therapy neoadjuvant to the surgery with a mean of 7 months (1-48) after radiotherapy. From the six patients potent before the surgery, three have presented erectile dysfunction. Urinary incontinence as well as bladder neck sclerosis occurred in two patients (22.2%). Biochemical recurrence occurred in two individuals (22.2%) 12 months after the surgery. Biochemical recurrence-free survival rate was 77.8% with median follow-up time of 30 months (8-102). CONCLUSION: Salvage radical prostatectomy is a safe and effective alternative for the treatment of locally recurrent prostate cancer after radiotherapy and brachytherapy.
id SBU-1_8ca13bc6ea8b3c5b6243adf9d9ea5eda
oai_identifier_str oai:scielo:S1677-55382006000500007
network_acronym_str SBU-1
network_name_str International Braz J Urol (Online)
repository_id_str
spelling Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancerprostatic neoplasmsradiotherapyrecurrencesalvage therapyprostatectomyOBJECTIVES: The treatment of recurrent prostate cancer after radiotherapy or brachytherapy through radical prostatectomy has been little indicated due to the concern over the procedure's morbidity. We present the experience of our service with postradiotherapy radical prostatectomy. MATERIALS AND METHODS: Between 1996 and 2002, 9 patients submitted to radiotherapy due to prostate cancer were treated with salvage surgery for locally recurrent disease. All patients had a biopsy of the prostate confirming the tumor recurrence, increase in the PSA levels and staging without evidence of a systemic disease. We have assessed the morbidity and the recurrence-free survival rate after salvage radical prostatectomy. RESULTS: Preradiotherapy PSA varied from 6.2 to 50 ng/mL (mean 17.3) and clinical staging T1, T2 and T3 in 33.3%, 44.4% and 22.2% of the patients respectively. The interval for the biopsy after conforming external beam radiotherapy or brachytherapy varied from 8 to 108 months (median: 36). Four patients received antiandrogenic therapy neoadjuvant to the surgery with a mean of 7 months (1-48) after radiotherapy. From the six patients potent before the surgery, three have presented erectile dysfunction. Urinary incontinence as well as bladder neck sclerosis occurred in two patients (22.2%). Biochemical recurrence occurred in two individuals (22.2%) 12 months after the surgery. Biochemical recurrence-free survival rate was 77.8% with median follow-up time of 30 months (8-102). CONCLUSION: Salvage radical prostatectomy is a safe and effective alternative for the treatment of locally recurrent prostate cancer after radiotherapy and brachytherapy.Sociedade Brasileira de Urologia2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000500007International braz j urol v.32 n.5 2006reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-55382006000500007info:eu-repo/semantics/openAccessDall'Oglio,Marcos F.Barreto,FrancualdoParanhos,MarioNesrallah,AdrianoNesrallah,LucianoSrougi,Migueleng2006-12-13T00:00:00Zoai:scielo:S1677-55382006000500007Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2006-12-13T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
title Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
spellingShingle Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
Dall'Oglio,Marcos F.
prostatic neoplasms
radiotherapy
recurrence
salvage therapy
prostatectomy
title_short Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
title_full Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
title_fullStr Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
title_full_unstemmed Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
title_sort Salvage radical prostatectomy: an alternative treatment for local recurrence of radioresistant cancer
author Dall'Oglio,Marcos F.
author_facet Dall'Oglio,Marcos F.
Barreto,Francualdo
Paranhos,Mario
Nesrallah,Adriano
Nesrallah,Luciano
Srougi,Miguel
author_role author
author2 Barreto,Francualdo
Paranhos,Mario
Nesrallah,Adriano
Nesrallah,Luciano
Srougi,Miguel
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Dall'Oglio,Marcos F.
Barreto,Francualdo
Paranhos,Mario
Nesrallah,Adriano
Nesrallah,Luciano
Srougi,Miguel
dc.subject.por.fl_str_mv prostatic neoplasms
radiotherapy
recurrence
salvage therapy
prostatectomy
topic prostatic neoplasms
radiotherapy
recurrence
salvage therapy
prostatectomy
description OBJECTIVES: The treatment of recurrent prostate cancer after radiotherapy or brachytherapy through radical prostatectomy has been little indicated due to the concern over the procedure's morbidity. We present the experience of our service with postradiotherapy radical prostatectomy. MATERIALS AND METHODS: Between 1996 and 2002, 9 patients submitted to radiotherapy due to prostate cancer were treated with salvage surgery for locally recurrent disease. All patients had a biopsy of the prostate confirming the tumor recurrence, increase in the PSA levels and staging without evidence of a systemic disease. We have assessed the morbidity and the recurrence-free survival rate after salvage radical prostatectomy. RESULTS: Preradiotherapy PSA varied from 6.2 to 50 ng/mL (mean 17.3) and clinical staging T1, T2 and T3 in 33.3%, 44.4% and 22.2% of the patients respectively. The interval for the biopsy after conforming external beam radiotherapy or brachytherapy varied from 8 to 108 months (median: 36). Four patients received antiandrogenic therapy neoadjuvant to the surgery with a mean of 7 months (1-48) after radiotherapy. From the six patients potent before the surgery, three have presented erectile dysfunction. Urinary incontinence as well as bladder neck sclerosis occurred in two patients (22.2%). Biochemical recurrence occurred in two individuals (22.2%) 12 months after the surgery. Biochemical recurrence-free survival rate was 77.8% with median follow-up time of 30 months (8-102). CONCLUSION: Salvage radical prostatectomy is a safe and effective alternative for the treatment of locally recurrent prostate cancer after radiotherapy and brachytherapy.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000500007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000500007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1677-55382006000500007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.32 n.5 2006
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
_version_ 1750318069828288512