The diagnostic value of FNDC5/Irisin in renal Cell Cancer

Detalhes bibliográficos
Autor(a) principal: Altay,Diler Us
Data de Publicação: 2018
Outros Autores: Keha,Esref Edip, Karagüzel,Ersagun, Menteşe,Ahmet, Yaman,Serap Ozer, Alver,Ahmet
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000400734
Resumo: ABSTRACT Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
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spelling The diagnostic value of FNDC5/Irisin in renal Cell CancerCarcinoma, Renal CellFNDC5 protein, rat [Supplementary Concept]Urologic NeoplasmsABSTRACT Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.Sociedade Brasileira de Urologia2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000400734International braz j urol v.44 n.4 2018reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2017.0404info:eu-repo/semantics/openAccessAltay,Diler UsKeha,Esref EdipKaragüzel,ErsagunMenteşe,AhmetYaman,Serap OzerAlver,Ahmeteng2018-08-08T00:00:00Zoai:scielo:S1677-55382018000400734Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2018-08-08T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv The diagnostic value of FNDC5/Irisin in renal Cell Cancer
title The diagnostic value of FNDC5/Irisin in renal Cell Cancer
spellingShingle The diagnostic value of FNDC5/Irisin in renal Cell Cancer
Altay,Diler Us
Carcinoma, Renal Cell
FNDC5 protein, rat [Supplementary Concept]
Urologic Neoplasms
title_short The diagnostic value of FNDC5/Irisin in renal Cell Cancer
title_full The diagnostic value of FNDC5/Irisin in renal Cell Cancer
title_fullStr The diagnostic value of FNDC5/Irisin in renal Cell Cancer
title_full_unstemmed The diagnostic value of FNDC5/Irisin in renal Cell Cancer
title_sort The diagnostic value of FNDC5/Irisin in renal Cell Cancer
author Altay,Diler Us
author_facet Altay,Diler Us
Keha,Esref Edip
Karagüzel,Ersagun
Menteşe,Ahmet
Yaman,Serap Ozer
Alver,Ahmet
author_role author
author2 Keha,Esref Edip
Karagüzel,Ersagun
Menteşe,Ahmet
Yaman,Serap Ozer
Alver,Ahmet
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Altay,Diler Us
Keha,Esref Edip
Karagüzel,Ersagun
Menteşe,Ahmet
Yaman,Serap Ozer
Alver,Ahmet
dc.subject.por.fl_str_mv Carcinoma, Renal Cell
FNDC5 protein, rat [Supplementary Concept]
Urologic Neoplasms
topic Carcinoma, Renal Cell
FNDC5 protein, rat [Supplementary Concept]
Urologic Neoplasms
description ABSTRACT Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000400734
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000400734
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1677-5538.ibju.2017.0404
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.44 n.4 2018
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
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