Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution

Detalhes bibliográficos
Autor(a) principal: Noronha,Marcelo R.
Data de Publicação: 2013
Outros Autores: Quintal,Maisa M. Q., Magna,Luis A., Reis,Leonardo O., Billis,Athanase, Meirelles,Luciana R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000600779
Resumo: Purpose To analyze controversial clinicopathologic predictors of biochemical recurrence after surgery: age, race, tumor extent on surgical specimen, tumor extent on needle biopsy, Gleason score 3 + 4 vs 4 + 3, and amount of extent of extraprostatic extension and positive surgical margins. Materials and Methods The needle biopsies and the correspondent surgical specimens were analyzed from 400 patients. Time to recurrence was analyzed with the Kaplan-Meier curves and risk of shorter time to recurrence using Cox univariate and multivariate analysis. Results Except for age, race, maximum percentage of cancer per core, and number of cores with cancer, all other variables studied were significantly predictive of time to biochemical recurrence using the Kaplan-Meier curves. In univariate analysis, except for focal extraprostatic extension, age, race, focal positive surgical margins, and maximum extent and percentage of cancer per core, all other variables were significantly predictive of shorter time to recurrence. On multivariate analysis, diffuse positive surgical margins and preoperative PSA were independent predictors. Conclusions Young patients and non-whites were not significantly associated with time to biochemical recurrence. The time consuming tumor extent evaluation in surgical specimens seems not to add additional information to other well established predictive findings. The higher predictive value of Gleason score 4 + 3 = 7 vs 3 + 4 = 7 discloses the importance of grade 4 as the predominant pattern. Extent and not simply presence or absent of extraprostatic extension should be informed. Most tumor extent evaluations on needle biopsies are predictive of time to biochemical recurrence, however, maximum percentage of cancer in all cores was the strongest predictor.
id SBU-1_dc54784950042669083c489720bc6cdd
oai_identifier_str oai:scielo:S1677-55382013000600779
network_acronym_str SBU-1
network_name_str International Braz J Urol (Online)
repository_id_str
spelling Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) InstitutionBiochemical ProcessesRecurrenceProstateProstate-Specific AntigenProstatectomyProstatic Neoplasms Purpose To analyze controversial clinicopathologic predictors of biochemical recurrence after surgery: age, race, tumor extent on surgical specimen, tumor extent on needle biopsy, Gleason score 3 + 4 vs 4 + 3, and amount of extent of extraprostatic extension and positive surgical margins. Materials and Methods The needle biopsies and the correspondent surgical specimens were analyzed from 400 patients. Time to recurrence was analyzed with the Kaplan-Meier curves and risk of shorter time to recurrence using Cox univariate and multivariate analysis. Results Except for age, race, maximum percentage of cancer per core, and number of cores with cancer, all other variables studied were significantly predictive of time to biochemical recurrence using the Kaplan-Meier curves. In univariate analysis, except for focal extraprostatic extension, age, race, focal positive surgical margins, and maximum extent and percentage of cancer per core, all other variables were significantly predictive of shorter time to recurrence. On multivariate analysis, diffuse positive surgical margins and preoperative PSA were independent predictors. Conclusions Young patients and non-whites were not significantly associated with time to biochemical recurrence. The time consuming tumor extent evaluation in surgical specimens seems not to add additional information to other well established predictive findings. The higher predictive value of Gleason score 4 + 3 = 7 vs 3 + 4 = 7 discloses the importance of grade 4 as the predominant pattern. Extent and not simply presence or absent of extraprostatic extension should be informed. Most tumor extent evaluations on needle biopsies are predictive of time to biochemical recurrence, however, maximum percentage of cancer in all cores was the strongest predictor. Sociedade Brasileira de Urologia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000600779International braz j urol v.39 n.6 2013reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-5538.IBJU.2013.06.03info:eu-repo/semantics/openAccessNoronha,Marcelo R.Quintal,Maisa M. Q.Magna,Luis A.Reis,Leonardo O.Billis,AthanaseMeirelles,Luciana R.eng2014-01-28T00:00:00Zoai:scielo:S1677-55382013000600779Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2014-01-28T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
title Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
spellingShingle Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
Noronha,Marcelo R.
Biochemical Processes
Recurrence
Prostate
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
title_short Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
title_full Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
title_fullStr Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
title_full_unstemmed Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
title_sort Controversial predictors of biochemical recurrence after radical prostatectomy: a study from a Latin American (Brazilian) Institution
author Noronha,Marcelo R.
author_facet Noronha,Marcelo R.
Quintal,Maisa M. Q.
Magna,Luis A.
Reis,Leonardo O.
Billis,Athanase
Meirelles,Luciana R.
author_role author
author2 Quintal,Maisa M. Q.
Magna,Luis A.
Reis,Leonardo O.
Billis,Athanase
Meirelles,Luciana R.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Noronha,Marcelo R.
Quintal,Maisa M. Q.
Magna,Luis A.
Reis,Leonardo O.
Billis,Athanase
Meirelles,Luciana R.
dc.subject.por.fl_str_mv Biochemical Processes
Recurrence
Prostate
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
topic Biochemical Processes
Recurrence
Prostate
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
description Purpose To analyze controversial clinicopathologic predictors of biochemical recurrence after surgery: age, race, tumor extent on surgical specimen, tumor extent on needle biopsy, Gleason score 3 + 4 vs 4 + 3, and amount of extent of extraprostatic extension and positive surgical margins. Materials and Methods The needle biopsies and the correspondent surgical specimens were analyzed from 400 patients. Time to recurrence was analyzed with the Kaplan-Meier curves and risk of shorter time to recurrence using Cox univariate and multivariate analysis. Results Except for age, race, maximum percentage of cancer per core, and number of cores with cancer, all other variables studied were significantly predictive of time to biochemical recurrence using the Kaplan-Meier curves. In univariate analysis, except for focal extraprostatic extension, age, race, focal positive surgical margins, and maximum extent and percentage of cancer per core, all other variables were significantly predictive of shorter time to recurrence. On multivariate analysis, diffuse positive surgical margins and preoperative PSA were independent predictors. Conclusions Young patients and non-whites were not significantly associated with time to biochemical recurrence. The time consuming tumor extent evaluation in surgical specimens seems not to add additional information to other well established predictive findings. The higher predictive value of Gleason score 4 + 3 = 7 vs 3 + 4 = 7 discloses the importance of grade 4 as the predominant pattern. Extent and not simply presence or absent of extraprostatic extension should be informed. Most tumor extent evaluations on needle biopsies are predictive of time to biochemical recurrence, however, maximum percentage of cancer in all cores was the strongest predictor.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000600779
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000600779
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1677-5538.IBJU.2013.06.03
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.39 n.6 2013
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
_version_ 1750318073291735040