Epigenetic targets in the diagnosis and treatment of prostate cancer

Detalhes bibliográficos
Autor(a) principal: Manoharan,Murugesan
Data de Publicação: 2007
Outros Autores: Ramachandran,Kavitha, Soloway,Mark S., Singal,Rakesh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000100003
Resumo: Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible. Novel epigenetic markers are being studied, which have the potential as sensitive diagnostic and prognostic marker. Variety of drugs targeting epigenetic changes are being studied, which can be effective individually or in combination with other conventional drugs in PC treatment. In this review, we discuss epigenetic changes associated with PC and their potential diagnostic and therapeutic applications including future areas of research.
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spelling Epigenetic targets in the diagnosis and treatment of prostate cancerprostate cancerDNA methylationepigenesis/geneticProstate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible. Novel epigenetic markers are being studied, which have the potential as sensitive diagnostic and prognostic marker. Variety of drugs targeting epigenetic changes are being studied, which can be effective individually or in combination with other conventional drugs in PC treatment. In this review, we discuss epigenetic changes associated with PC and their potential diagnostic and therapeutic applications including future areas of research.Sociedade Brasileira de Urologia2007-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000100003International braz j urol v.33 n.1 2007reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-55382007000100003info:eu-repo/semantics/openAccessManoharan,MurugesanRamachandran,KavithaSoloway,Mark S.Singal,Rakesheng2007-04-05T00:00:00Zoai:scielo:S1677-55382007000100003Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2007-04-05T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv Epigenetic targets in the diagnosis and treatment of prostate cancer
title Epigenetic targets in the diagnosis and treatment of prostate cancer
spellingShingle Epigenetic targets in the diagnosis and treatment of prostate cancer
Manoharan,Murugesan
prostate cancer
DNA methylation
epigenesis/genetic
title_short Epigenetic targets in the diagnosis and treatment of prostate cancer
title_full Epigenetic targets in the diagnosis and treatment of prostate cancer
title_fullStr Epigenetic targets in the diagnosis and treatment of prostate cancer
title_full_unstemmed Epigenetic targets in the diagnosis and treatment of prostate cancer
title_sort Epigenetic targets in the diagnosis and treatment of prostate cancer
author Manoharan,Murugesan
author_facet Manoharan,Murugesan
Ramachandran,Kavitha
Soloway,Mark S.
Singal,Rakesh
author_role author
author2 Ramachandran,Kavitha
Soloway,Mark S.
Singal,Rakesh
author2_role author
author
author
dc.contributor.author.fl_str_mv Manoharan,Murugesan
Ramachandran,Kavitha
Soloway,Mark S.
Singal,Rakesh
dc.subject.por.fl_str_mv prostate cancer
DNA methylation
epigenesis/genetic
topic prostate cancer
DNA methylation
epigenesis/genetic
description Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible. Novel epigenetic markers are being studied, which have the potential as sensitive diagnostic and prognostic marker. Variety of drugs targeting epigenetic changes are being studied, which can be effective individually or in combination with other conventional drugs in PC treatment. In this review, we discuss epigenetic changes associated with PC and their potential diagnostic and therapeutic applications including future areas of research.
publishDate 2007
dc.date.none.fl_str_mv 2007-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1677-55382007000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.33 n.1 2007
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
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