Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands

• Autor(a) principal: Mello, Marcos Vinícius Palmeira de
• Data de Publicação: 2023
• Outros Autores: Caballero, Ana Belen, Herrera-Ramírez, Piedad, Costa, Analu Rocha, Santana, Savyo Souza, Guedes, Guilherme Pereira, Caubet, Amparo, Batista, Alzir Azevedo, Gamez, Patrick, Lanznaster, Mauricio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFSCAR
• Texto Completo: https://doi.org/10.1016/j.jinorgbio.2023.112345; https://repositorio.ufscar.br/handle/ufscar/19283
• topic: Cobalt(III) complexes; Prodrugs; Hypoxia-activated drug delivery; Anticancer drugs; DNA binding; b-Ketoester; CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA::CAMPOS DE COORDENACAO; CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA::QUIMICA BIO-INORGANICA; CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA

Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2⋅H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1¡ = methylacetoacetate; L2¡ = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via Xray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37◦C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction.