Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos

Detalhes bibliográficos
Autor(a) principal: Marins, Bruna Aparecida Barbosa
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFSCAR
Texto Completo: https://repositorio.ufscar.br/handle/ufscar/10754
Resumo: Escalation with overdose control proportional hazards is a Bayesian method with overdose control that estimates the maximum tolerated dose (MTD) assuming that the time a patient takes to show toxicity follows the proportional hazards model. In this work, we analyse the consequences of adopting a method based on the proportional hazard model when the time until toxicity follows the proportional survival model. In order to seek to answer if we would have an overestimate or an underestimate of MTD, simulations were performed in which we considered proportional odds survival data and application of the EWOC-PH method. As an extension of the EWOC-PH method, we propose the EWOC-POS method which assumes that time until toxicity follows the proportional odds survival model.
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spelling Marins, Bruna Aparecida BarbosaCobre, Julianahttp://lattes.cnpq.br/1042802390444616http://lattes.cnpq.br/6574049419922178cb2f5ee5-e1a6-47ba-a950-e5812f4c1ced2018-12-04T12:20:51Z2018-12-04T12:20:51Z2018-10-03MARINS, Bruna Aparecida Barbosa. Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos. 2018. Dissertação (Mestrado em Estatística) – Universidade Federal de São Carlos, São Carlos, 2018. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10754.https://repositorio.ufscar.br/handle/ufscar/10754Escalation with overdose control proportional hazards is a Bayesian method with overdose control that estimates the maximum tolerated dose (MTD) assuming that the time a patient takes to show toxicity follows the proportional hazards model. In this work, we analyse the consequences of adopting a method based on the proportional hazard model when the time until toxicity follows the proportional survival model. In order to seek to answer if we would have an overestimate or an underestimate of MTD, simulations were performed in which we considered proportional odds survival data and application of the EWOC-PH method. As an extension of the EWOC-PH method, we propose the EWOC-POS method which assumes that time until toxicity follows the proportional odds survival model.Escalonamento com controle de overdose (EWOC-PH, \textit{escalation with overdose control proporcional hazards}) é um método bayesiano com controle de overdose que estima a dose máxima tolerada (MTD, \textit{maximum tolerated dose}) assumindo que o tempo que um paciente leva para apresentar toxicidade segue o modelo de riscos proporcionais. Neste trabalho analisamos quais são as consequências em adotarmos um método que se baseia no modelo de riscos proporcionais quando o tempo até toxicidade segue o modelo de chances de sobrevivência proporcionais. A fim de buscar responder se teríamos uma superestimativa ou uma subestimativa da MTD foram feitas simulações em que consideramos dados de chances de sobrevivência proporcionais e aplicação do método EWOC-PH para analisarmos a MTD. Como uma extensão do método EWOC-PH, propomos o método EWOC-POS que assume que os tempos seguem o modelo de chances de sobrevivência proporcionais.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPES/DS - Demanda SocialporUniversidade Federal de São CarlosCâmpus São CarlosPrograma Interinstitucional de Pós-Graduação em Estatística - PIPGEsUFSCarChances de sobrevivências proporcionaisControle de overdoseDose máxima toleradaRiscos proporcionaisMaximum tolerated doseOverdose controlProportional odds survivalProportional hazardsCIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICAEstudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicosStudy of the impact of model choice for overdose control in phase I of clinical trialsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisOnline600e35fb172-42e7-4781-9545-31475b33f556info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALfinal revisada.pdffinal revisada.pdfapplication/pdf1589353https://repositorio.ufscar.br/bitstream/ufscar/10754/1/final%20revisada.pdf2534f39cce121de125f2906beeb57347MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81957https://repositorio.ufscar.br/bitstream/ufscar/10754/3/license.txtae0398b6f8b235e40ad82cba6c50031dMD53TEXTfinal revisada.pdf.txtfinal revisada.pdf.txtExtracted texttext/plain53147https://repositorio.ufscar.br/bitstream/ufscar/10754/4/final%20revisada.pdf.txte027ca1449952eab34a968c3351b512cMD54THUMBNAILfinal revisada.pdf.jpgfinal revisada.pdf.jpgIM Thumbnailimage/jpeg7612https://repositorio.ufscar.br/bitstream/ufscar/10754/5/final%20revisada.pdf.jpg907ef8131e5d1e115245b4d1ad46079eMD55ufscar/107542023-09-18 18:31:18.318oai:repositorio.ufscar.br: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Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222023-09-18T18:31:18Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false
dc.title.por.fl_str_mv Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
dc.title.alternative.eng.fl_str_mv Study of the impact of model choice for overdose control in phase I of clinical trials
title Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
spellingShingle Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
Marins, Bruna Aparecida Barbosa
Chances de sobrevivências proporcionais
Controle de overdose
Dose máxima tolerada
Riscos proporcionais
Maximum tolerated dose
Overdose control
Proportional odds survival
Proportional hazards
CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA
title_short Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
title_full Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
title_fullStr Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
title_full_unstemmed Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
title_sort Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
author Marins, Bruna Aparecida Barbosa
author_facet Marins, Bruna Aparecida Barbosa
author_role author
dc.contributor.authorlattes.por.fl_str_mv http://lattes.cnpq.br/6574049419922178
dc.contributor.author.fl_str_mv Marins, Bruna Aparecida Barbosa
dc.contributor.advisor1.fl_str_mv Cobre, Juliana
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1042802390444616
dc.contributor.authorID.fl_str_mv cb2f5ee5-e1a6-47ba-a950-e5812f4c1ced
contributor_str_mv Cobre, Juliana
dc.subject.por.fl_str_mv Chances de sobrevivências proporcionais
Controle de overdose
Dose máxima tolerada
Riscos proporcionais
Maximum tolerated dose
topic Chances de sobrevivências proporcionais
Controle de overdose
Dose máxima tolerada
Riscos proporcionais
Maximum tolerated dose
Overdose control
Proportional odds survival
Proportional hazards
CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA
dc.subject.eng.fl_str_mv Overdose control
Proportional odds survival
Proportional hazards
dc.subject.cnpq.fl_str_mv CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA
description Escalation with overdose control proportional hazards is a Bayesian method with overdose control that estimates the maximum tolerated dose (MTD) assuming that the time a patient takes to show toxicity follows the proportional hazards model. In this work, we analyse the consequences of adopting a method based on the proportional hazard model when the time until toxicity follows the proportional survival model. In order to seek to answer if we would have an overestimate or an underestimate of MTD, simulations were performed in which we considered proportional odds survival data and application of the EWOC-PH method. As an extension of the EWOC-PH method, we propose the EWOC-POS method which assumes that time until toxicity follows the proportional odds survival model.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-04T12:20:51Z
dc.date.available.fl_str_mv 2018-12-04T12:20:51Z
dc.date.issued.fl_str_mv 2018-10-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARINS, Bruna Aparecida Barbosa. Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos. 2018. Dissertação (Mestrado em Estatística) – Universidade Federal de São Carlos, São Carlos, 2018. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10754.
dc.identifier.uri.fl_str_mv https://repositorio.ufscar.br/handle/ufscar/10754
identifier_str_mv MARINS, Bruna Aparecida Barbosa. Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos. 2018. Dissertação (Mestrado em Estatística) – Universidade Federal de São Carlos, São Carlos, 2018. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10754.
url https://repositorio.ufscar.br/handle/ufscar/10754
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language por
dc.relation.confidence.fl_str_mv 600
dc.relation.authority.fl_str_mv e35fb172-42e7-4781-9545-31475b33f556
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de São Carlos
Câmpus São Carlos
dc.publisher.program.fl_str_mv Programa Interinstitucional de Pós-Graduação em Estatística - PIPGEs
dc.publisher.initials.fl_str_mv UFSCar
publisher.none.fl_str_mv Universidade Federal de São Carlos
Câmpus São Carlos
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFSCAR
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institution UFSCAR
reponame_str Repositório Institucional da UFSCAR
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