Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFSCAR |
Texto Completo: | https://repositorio.ufscar.br/handle/ufscar/1365 |
Resumo: | Cancer, is the name given to a set of more than 100 diseases that have in common the uncontrolled growth of cells that invade tissues and organs. It is occurs for several reasons, among them changes in DNA that may be caused by many factors such as oxidative stress, exposure to sunlight and smoking. Many efforts are being made in the search for treatments that may prolong a patient's life or even cure of the disease. In this quest, many chemotherapeutic compounds have been developed in an attempt to combat the different types of cancer. Among these various compounds were developed directly or indirectly from natural products derived from plants or bioactive compounds such as camptothecin, extracted from the bark of Camptotheca acuminata plant and taxol derivative of Taxus brevifolia. Flavonoids are a group of secondary metabolites, which belong to the class of polyphenols. They are found in several species of plants, especially in fruits, seeds and flowers. Many of them were described as having high antioxidant, anti-inflammatory, antiallergic, hepatoprotective and antitumor capacity. The main groups are derived from flavonoids are: flavanols, flavonols, isoflavones, anthocyanidins, flavonones, and flavones. The naringenin belongs to the group of flavonones commonly found in citrus fruits and has shown in previous studies to possess anti-tumor action. To make more effective the action of these compounds, many have been linked to metal complexes which increases the cytotoxicity of the same. One of the biggest challenges in the field of cancer research is to obtain a chemotherapeutic compound that is cytotoxic to tumor cells only and has fewer side effects compared to drugs currently used. Thus, the aim of this study was to evaluate and compare the cytotoxic effect of naringenin and naringenin complexed with copper and 2,2 '-bipyridine, in triple-negative breast cancer cell line, MDA-MB-231 and understand some of the mechanisms molecular action involved. |
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Conceição Filho, Júlio CésarCominetti, Márcia Reginahttp://genos.cnpq.br:12010/dwlattes/owa/prc_imp_cv_int?f_cod=K4795315E1http://lattes.cnpq.br/1613484530528398aa463135-9429-4903-8024-fcafaa41251b2016-06-02T19:23:00Z2014-08-282016-06-02T19:23:00Z2014-05-07CONCEIÇÃO FILHO, Júlio César. Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama. 2014. 56 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de São Carlos, São Carlos, 2014.https://repositorio.ufscar.br/handle/ufscar/1365Cancer, is the name given to a set of more than 100 diseases that have in common the uncontrolled growth of cells that invade tissues and organs. It is occurs for several reasons, among them changes in DNA that may be caused by many factors such as oxidative stress, exposure to sunlight and smoking. Many efforts are being made in the search for treatments that may prolong a patient's life or even cure of the disease. In this quest, many chemotherapeutic compounds have been developed in an attempt to combat the different types of cancer. Among these various compounds were developed directly or indirectly from natural products derived from plants or bioactive compounds such as camptothecin, extracted from the bark of Camptotheca acuminata plant and taxol derivative of Taxus brevifolia. Flavonoids are a group of secondary metabolites, which belong to the class of polyphenols. They are found in several species of plants, especially in fruits, seeds and flowers. Many of them were described as having high antioxidant, anti-inflammatory, antiallergic, hepatoprotective and antitumor capacity. The main groups are derived from flavonoids are: flavanols, flavonols, isoflavones, anthocyanidins, flavonones, and flavones. The naringenin belongs to the group of flavonones commonly found in citrus fruits and has shown in previous studies to possess anti-tumor action. To make more effective the action of these compounds, many have been linked to metal complexes which increases the cytotoxicity of the same. One of the biggest challenges in the field of cancer research is to obtain a chemotherapeutic compound that is cytotoxic to tumor cells only and has fewer side effects compared to drugs currently used. Thus, the aim of this study was to evaluate and compare the cytotoxic effect of naringenin and naringenin complexed with copper and 2,2 '-bipyridine, in triple-negative breast cancer cell line, MDA-MB-231 and understand some of the mechanisms molecular action involved.O câncer, a segunda doença que mais mata no mundo, é o nome dado a um conjunto de mais de 100 doenças que têm em comum o crescimento desordenado de células, que invadem tecidos e órgãos. Tal fenômeno ocorre por vários motivos, dentre eles, alterações no DNA que podem ser causadas por diversos fatores como estresse oxidativo, exposição à radiação solar e tabagismo, entre outros. Muitos esforços estão sendo empregados na busca de tratamentos que possam prolongar a vida de um paciente ou até mesmo curar em definitivo a doença. Nesta busca, muitos compostos quimioterápicos vêm sendo desenvolvidos na tentativa de combater os diversos os tipos de câncer. Dentre tais compostos vários foram desenvolvidos direta ou indiretamente a partir de produtos naturais, derivados de plantas ou de compostos bioativos como a camptotecina, extraída da casca da planta Camptotheca acuminata e o taxol, derivado da Taxus brevifolia. Os flavonoides formam um grupo de metabólitos secundários, os quais pertencem à classe dos polifenóis. Eles são encontrados em diversas espécies de plantas, especialmente em frutas, sementes e flores. Muitos deles foram descritos como tendo alta capacidade antioxidante, anti-inflamatória, antialérgica, hepatoprotetora e antitumoral. Os principais grupos derivados dos flavonóides são: os flavanóis, flavonóis, isoflavonas, antocianidinas, flavononas, e flavonas. A naringenina pertence ao grupo das flavononas comumente encontradas em frutas cítricas e já demonstrou, em estudos anteriores, possuir uma ação antitumoral. Para tornar mais efetiva a ação destes compostos, muitos têm sido ligados a complexos metálicos o que, por diversas maneiras, aumenta a citotoxidade dos mesmos. Um dos maiores desafios para campo de estudo do câncer está em obter um composto quimioterápico que seja citotóxico somente para células tumorais e que tenha menores efeitos colaterais comparados com os fármacos utilizados atualmente. Desta forma, o objetivo deste estudo foi avaliar e comparar o efeito citotóxico da naringenina e da naringenina complexada com cobre e 2,2 -bipiridina, na linhagem de câncer de mama triplo-negativo MDA-MB-231 e compreender alguns dos mecanismos de ação molecular envolvidos.Financiadora de Estudos e Projetosapplication/pdfporUniversidade Federal de São CarlosPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFUFSCarBRCâncerProdutos naturaisComplexos metálicosCIENCIAS BIOLOGICAS::FISIOLOGIAEfeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mamainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-1-16fbc146e-b953-4aee-ae8e-f34e0b675891info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINAL6091.pdfapplication/pdf1745828https://repositorio.ufscar.br/bitstream/ufscar/1365/1/6091.pdf4fccc10ea13db3735e5df6b6d9d7efc0MD51TEXT6091.pdf.txt6091.pdf.txtExtracted texttext/plain0https://repositorio.ufscar.br/bitstream/ufscar/1365/2/6091.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD52THUMBNAIL6091.pdf.jpg6091.pdf.jpgIM Thumbnailimage/jpeg4771https://repositorio.ufscar.br/bitstream/ufscar/1365/3/6091.pdf.jpgbf2274f922300ece47ae0c49ecf06ab1MD53ufscar/13652023-09-18 18:31:29.082oai:repositorio.ufscar.br:ufscar/1365Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222023-09-18T18:31:29Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.por.fl_str_mv |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
title |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
spellingShingle |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama Conceição Filho, Júlio César Câncer Produtos naturais Complexos metálicos CIENCIAS BIOLOGICAS::FISIOLOGIA |
title_short |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
title_full |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
title_fullStr |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
title_full_unstemmed |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
title_sort |
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama |
author |
Conceição Filho, Júlio César |
author_facet |
Conceição Filho, Júlio César |
author_role |
author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/1613484530528398 |
dc.contributor.author.fl_str_mv |
Conceição Filho, Júlio César |
dc.contributor.advisor1.fl_str_mv |
Cominetti, Márcia Regina |
dc.contributor.advisor1Lattes.fl_str_mv |
http://genos.cnpq.br:12010/dwlattes/owa/prc_imp_cv_int?f_cod=K4795315E1 |
dc.contributor.authorID.fl_str_mv |
aa463135-9429-4903-8024-fcafaa41251b |
contributor_str_mv |
Cominetti, Márcia Regina |
dc.subject.por.fl_str_mv |
Câncer Produtos naturais Complexos metálicos |
topic |
Câncer Produtos naturais Complexos metálicos CIENCIAS BIOLOGICAS::FISIOLOGIA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FISIOLOGIA |
description |
Cancer, is the name given to a set of more than 100 diseases that have in common the uncontrolled growth of cells that invade tissues and organs. It is occurs for several reasons, among them changes in DNA that may be caused by many factors such as oxidative stress, exposure to sunlight and smoking. Many efforts are being made in the search for treatments that may prolong a patient's life or even cure of the disease. In this quest, many chemotherapeutic compounds have been developed in an attempt to combat the different types of cancer. Among these various compounds were developed directly or indirectly from natural products derived from plants or bioactive compounds such as camptothecin, extracted from the bark of Camptotheca acuminata plant and taxol derivative of Taxus brevifolia. Flavonoids are a group of secondary metabolites, which belong to the class of polyphenols. They are found in several species of plants, especially in fruits, seeds and flowers. Many of them were described as having high antioxidant, anti-inflammatory, antiallergic, hepatoprotective and antitumor capacity. The main groups are derived from flavonoids are: flavanols, flavonols, isoflavones, anthocyanidins, flavonones, and flavones. The naringenin belongs to the group of flavonones commonly found in citrus fruits and has shown in previous studies to possess anti-tumor action. To make more effective the action of these compounds, many have been linked to metal complexes which increases the cytotoxicity of the same. One of the biggest challenges in the field of cancer research is to obtain a chemotherapeutic compound that is cytotoxic to tumor cells only and has fewer side effects compared to drugs currently used. Thus, the aim of this study was to evaluate and compare the cytotoxic effect of naringenin and naringenin complexed with copper and 2,2 '-bipyridine, in triple-negative breast cancer cell line, MDA-MB-231 and understand some of the mechanisms molecular action involved. |
publishDate |
2014 |
dc.date.available.fl_str_mv |
2014-08-28 2016-06-02T19:23:00Z |
dc.date.issued.fl_str_mv |
2014-05-07 |
dc.date.accessioned.fl_str_mv |
2016-06-02T19:23:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
CONCEIÇÃO FILHO, Júlio César. Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama. 2014. 56 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de São Carlos, São Carlos, 2014. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufscar.br/handle/ufscar/1365 |
identifier_str_mv |
CONCEIÇÃO FILHO, Júlio César. Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama. 2014. 56 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de São Carlos, São Carlos, 2014. |
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https://repositorio.ufscar.br/handle/ufscar/1365 |
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Universidade Federal de São Carlos |
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