Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19

• Autor(a) principal: Neves, Fabio Fernandes
• Data de Publicação: 2022
• Outros Autores: Pott-Junior, Henrique, Santos, Sigrid Sousa, Cominetti, Marcia Regina, Freire, Caio Cesar de Melo, Cunha, Anderson Ferreira da, Jordão Júnior, Alceu Afonso
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFSCAR
• Texto Completo: https://doi.org/10.1016/j.clnesp.2022.05.027; https://repositorio.ufscar.br/handle/ufscar/18414; https://clinicalnutritionespen.com/article/S2405-4577(22)00293-5/fulltext
• topic: COVID-19; SARS-Cov-2; vitamina d; CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA

Several studies have shown conflicting results for the relationship between vitamin D deficiency and COVID-19 outcomes. Here, we aimed to evaluate whether plasma 25(OH)D levels predict mortality in adults admitted with COVID-19, considering potential confounders. Methods: We conducted a retrospective cohort study that included 115 adults (age 62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Subjects were classified into two groups according to their plasma levels of 25(OH)D: sufficiency ( 50 nmol/L) and the deficiency (<50 nmol/L). The diagnosis of COVID-19 was performed using real-time polymerase chain reaction (qPCR). In addition, direct competitive chemiluminescence immunoassay assessed serum 25(OH)D levels. Results: The all-cause 30-day mortality was 13.8% (95% CI: 6.5%e21%) in the group of patients with sufficient plasma 25(OH)D levels and 32.1% (95% CI: 14.8%e49.4%) among those with deficient plasma 25(OH)D levels. Cox regression showed that plasma 25(OH)D levels remained a significant predictor of mortality even after adjusting for the covariates sex, age, length of the delay between symptom onset and hospitalization, and disease severity (HR ¼ 0.98, 95% CI: 0.96e1.00; p ¼ 0.02). Conclusion: Vitamin D deficiency predicts higher mortality risk in adults with COVID-19.