Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study

• Autor(a) principal: Neves, Fabio Fernandes
• Data de Publicação: 2023
• Outros Autores: Pott-Junior, Henrique, Yamashita, Kaori Maria Carolina, Santos, Sigrid de Sousa, Cominetti, Marcia Regina, Freire, Caio Cesar de Melo, Cunha, Anderson Ferreira, Jordão Júnior, Alceu Afonso
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFSCAR
• Texto Completo: https://doi.org/10.1016/j.freeradbiomed.2023.06.026; https://repositorio.ufscar.br/handle/ufscar/18417; https://www.sciencedirect.com/science/article/abs/pii/S0891584923005130
• topic: COVID-19; SARS-Cov-2; Estresse oxidativo; Espécies reativas do oxigênio; CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA

In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates reactive oxygen species levels, harms cell structures, and directly increases disease severity and mortality. We aimed to evaluate whether plasma oxidative stress biomarker levels could predict mortality in adults admitted with Coronavirus Disease 2019 (COVID-19), considering potential confounders. We conducted a cohort study of 115 adults (62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Serum levels of α-tocopherol, glutathione, superoxide dismutase, 8-hydroxy-2′-deoxyguanosine, malondialdehyde, and advanced oxidation protein products were quantified at COVID-19 diagnosis using real-time polymerase chain reaction. Serum levels of α-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products differed significantly between survivors and non-survivors. Serum glutathione levels below 327.2 μmol/mL were associated with a significant risk of death in COVID-19 patients, even after accounting for other factors (adjusted hazard ratio = 3.12 [95% CI: 1.83–5.33]).