Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review

Detalhes bibliográficos
Autor(a) principal: Muñoz, Humberto
Data de Publicação: 2021
Outros Autores: Zuñiga, Natalia, Rivera, César
Tipo de documento: preprint
Idioma: spa
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/3174
Resumo: In recent years, saliva has been shown to possess biomarkers capable of diagnosing different diseases, including gastric cancer. Here we present a systematic review (PROSPERO CRD42021259519) with the aim of evaluating biomarkers closer to clinical use. We identified markers of different molecular nature, of which 3 proteins stand out (CSTB, TPI1 and DMBT1), which in the validation stage presented high diagnostic accuracy. Salivary biomarkers have great potential for the detection of stomach cancer; however, it is recommended in subsequent studies to improve the design and execution phases of the research in order to obtain better quality evidence.
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spelling Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic reviewBiomarcadores salivales validados para el diagnóstico de cáncer gástrico: una revisión sistemáticaBiomarkersSalivaStomach NeoplasmsBiomarcadoresSalivaNeoplasias gástricasIn recent years, saliva has been shown to possess biomarkers capable of diagnosing different diseases, including gastric cancer. Here we present a systematic review (PROSPERO CRD42021259519) with the aim of evaluating biomarkers closer to clinical use. We identified markers of different molecular nature, of which 3 proteins stand out (CSTB, TPI1 and DMBT1), which in the validation stage presented high diagnostic accuracy. Salivary biomarkers have great potential for the detection of stomach cancer; however, it is recommended in subsequent studies to improve the design and execution phases of the research in order to obtain better quality evidence.Durante los últimos años la saliva ha demostrado poseer biomarcadores capaces de diagnosticar distintas enfermedades, incluyendo el cáncer gástrico. Aquí presentamos una revisión sistemática (PRÓSPERO CRD42021259519) con el objetivo de evaluar biomarcadores más próximos a su utilización clínica. Identificamos marcadores de distinta naturaleza molecular, de los cuales destacan 3 proteínas (CSTB, TPI1 y DMBT1), que en etapa de validación presentaron alta exactitud diagnóstica. Los biomarcadores salivales tienen gran potencial para la detección de cáncer de estómago, sin embargo, se recomienda en estudios posteriores perfeccionar fases del diseño y ejecución de la investigación, para obtener mejor calidad en la evidencia.SciELO PreprintsSciELO PreprintsSciELO Preprints2021-11-12info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/317410.1590/SciELOPreprints.3174spahttps://preprints.scielo.org/index.php/scielo/article/view/3174/5714Copyright (c) 2021 Humberto Muñoz, Natalia Zuñiga, César Riverahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMuñoz, HumbertoZuñiga, NataliaRivera, Césarreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-11-10T01:17:36Zoai:ops.preprints.scielo.org:preprint/3174Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-11-10T01:17:36SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
Biomarcadores salivales validados para el diagnóstico de cáncer gástrico: una revisión sistemática
title Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
spellingShingle Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
Muñoz, Humberto
Biomarkers
Saliva
Stomach Neoplasms
Biomarcadores
Saliva
Neoplasias gástricas
title_short Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
title_full Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
title_fullStr Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
title_full_unstemmed Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
title_sort Validated salivary biomarkers for the diagnosis of gastric cancer: a systematic review
author Muñoz, Humberto
author_facet Muñoz, Humberto
Zuñiga, Natalia
Rivera, César
author_role author
author2 Zuñiga, Natalia
Rivera, César
author2_role author
author
dc.contributor.author.fl_str_mv Muñoz, Humberto
Zuñiga, Natalia
Rivera, César
dc.subject.por.fl_str_mv Biomarkers
Saliva
Stomach Neoplasms
Biomarcadores
Saliva
Neoplasias gástricas
topic Biomarkers
Saliva
Stomach Neoplasms
Biomarcadores
Saliva
Neoplasias gástricas
description In recent years, saliva has been shown to possess biomarkers capable of diagnosing different diseases, including gastric cancer. Here we present a systematic review (PROSPERO CRD42021259519) with the aim of evaluating biomarkers closer to clinical use. We identified markers of different molecular nature, of which 3 proteins stand out (CSTB, TPI1 and DMBT1), which in the validation stage presented high diagnostic accuracy. Salivary biomarkers have great potential for the detection of stomach cancer; however, it is recommended in subsequent studies to improve the design and execution phases of the research in order to obtain better quality evidence.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/3174
10.1590/SciELOPreprints.3174
url https://preprints.scielo.org/index.php/scielo/preprint/view/3174
identifier_str_mv 10.1590/SciELOPreprints.3174
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/3174/5714
dc.rights.driver.fl_str_mv Copyright (c) 2021 Humberto Muñoz, Natalia Zuñiga, César Rivera
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Humberto Muñoz, Natalia Zuñiga, César Rivera
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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