Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.

Detalhes bibliográficos
Autor(a) principal: Torres, Carolina
Data de Publicação: 2021
Outros Autores: Debat, Humberto, Viegas, Mariana
Tipo de documento: preprint
Idioma: spa
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/2886
Resumo: Since December 2020, the detection of emerging viral variants of SARS-CoV-2 has attracted the attention of the scientific community and governments at the national and international levels. Some versions of the virus characterized by genetic/evolutionary, epidemiological and/or phenotypic changes have been classified by the WHO as alerts for further monitoring, variants of interest (VOI), or variants of concern (VOC). At the international level, the current situation of variants reflects the sustained advance of the VOC Delta, driving new waves in much of the globe. On the other hand, South America, which exhibits an exceptional landscape of variants dominated by the regionally emerged Gamma (VOC) and Lambda (VOI) begins to face Delta's entry into a dynamic equilibrium of tension between viral evolution, immunity of the population associated with the second wave, and the asymmetry of vaccination campaigns and regional health policies. In this review, we present an update of the latest advances regarding the study of these variants, their potential impact on the epidemiological dynamics and vaccine effectiveness, with a special focus on the Latin American situation of the COVID-19 pandemic, in the second half of 2021.
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spelling Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.Características biológicas de las variantes de SARS-CoV-2 de interés epidemiológico y su impacto sobre la eficacia y la efectividad vacunalSARS-CoV-2Variants of ConcernVariants of InterestCOVID-19Vaccine effectivenessGammaLambdaDeltaSARS-CoV-2Variantes de PreocupaciónCOVID-19Efectividad VacunalGammaLambdaDeltaSince December 2020, the detection of emerging viral variants of SARS-CoV-2 has attracted the attention of the scientific community and governments at the national and international levels. Some versions of the virus characterized by genetic/evolutionary, epidemiological and/or phenotypic changes have been classified by the WHO as alerts for further monitoring, variants of interest (VOI), or variants of concern (VOC). At the international level, the current situation of variants reflects the sustained advance of the VOC Delta, driving new waves in much of the globe. On the other hand, South America, which exhibits an exceptional landscape of variants dominated by the regionally emerged Gamma (VOC) and Lambda (VOI) begins to face Delta's entry into a dynamic equilibrium of tension between viral evolution, immunity of the population associated with the second wave, and the asymmetry of vaccination campaigns and regional health policies. In this review, we present an update of the latest advances regarding the study of these variants, their potential impact on the epidemiological dynamics and vaccine effectiveness, with a special focus on the Latin American situation of the COVID-19 pandemic, in the second half of 2021.Desde el mes de diciembre de 2020, la detección de variantes virales emergentes del SARS-CoV-2 ha llamado la atención de la comunidad científica y de los gobiernos a nivel nacional e internacional. Algunas versiones del virus caracterizadas por cambios genéticos, epidemiológicos y/o fenotípicos han sido clasificados por la OMS como variantes para monitoreo adicional, variantes de interés (VOI) o variantes de preocupación (VOC). A nivel internacional la situación actual de variantes refleja el avance sostenido de la VOC Delta, impulsando nuevas olas de infecciones en gran parte del mundo. Por otro lado, América del Sur exhibe un paisaje particular de linajes circulantes, dominado por las variantes de emergencia regional Gamma (VOC) y Lambda (VOI). Esta región empieza a afrontar el ingreso de Delta en un equilibrio dinámico de tensión entre la evolución viral, la inmunidad adquirida de la población asociada a la segunda ola, y la asimetría en las campañas de vacunación y en las políticas sanitarias regionales. En esta revisión presentamos una actualización de los últimos avances relativos al estudio de las variantes virales emergentes del SARS-CoV-2, su potencial impacto en la dinámica epidemiológica y en la efectividad vacunal, con especial foco en la situación regional latinoamericana de pandemia de la COVID-19 en el segundo semestre de 2021.SciELO PreprintsSciELO PreprintsSciELO Preprints2021-09-02info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/288610.1590/SciELOPreprints.2886spahttps://preprints.scielo.org/index.php/scielo/article/view/2886/5099Copyright (c) 2021 Carolina Torres, Humberto Debat, Mariana Viegashttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTorres, CarolinaDebat, HumbertoViegas, Marianareponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-09-01T00:53:16Zoai:ops.preprints.scielo.org:preprint/2886Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-09-01T00:53:16SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
Características biológicas de las variantes de SARS-CoV-2 de interés epidemiológico y su impacto sobre la eficacia y la efectividad vacunal
title Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
spellingShingle Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
Torres, Carolina
SARS-CoV-2
Variants of Concern
Variants of Interest
COVID-19
Vaccine effectiveness
Gamma
Lambda
Delta
SARS-CoV-2
Variantes de Preocupación
COVID-19
Efectividad Vacunal
Gamma
Lambda
Delta
title_short Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
title_full Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
title_fullStr Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
title_full_unstemmed Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
title_sort Biological characteristics of SARS-CoV-2 variants of epidemiological interest and their impact on vaccine efficacy and effectiveness.
author Torres, Carolina
author_facet Torres, Carolina
Debat, Humberto
Viegas, Mariana
author_role author
author2 Debat, Humberto
Viegas, Mariana
author2_role author
author
dc.contributor.author.fl_str_mv Torres, Carolina
Debat, Humberto
Viegas, Mariana
dc.subject.por.fl_str_mv SARS-CoV-2
Variants of Concern
Variants of Interest
COVID-19
Vaccine effectiveness
Gamma
Lambda
Delta
SARS-CoV-2
Variantes de Preocupación
COVID-19
Efectividad Vacunal
Gamma
Lambda
Delta
topic SARS-CoV-2
Variants of Concern
Variants of Interest
COVID-19
Vaccine effectiveness
Gamma
Lambda
Delta
SARS-CoV-2
Variantes de Preocupación
COVID-19
Efectividad Vacunal
Gamma
Lambda
Delta
description Since December 2020, the detection of emerging viral variants of SARS-CoV-2 has attracted the attention of the scientific community and governments at the national and international levels. Some versions of the virus characterized by genetic/evolutionary, epidemiological and/or phenotypic changes have been classified by the WHO as alerts for further monitoring, variants of interest (VOI), or variants of concern (VOC). At the international level, the current situation of variants reflects the sustained advance of the VOC Delta, driving new waves in much of the globe. On the other hand, South America, which exhibits an exceptional landscape of variants dominated by the regionally emerged Gamma (VOC) and Lambda (VOI) begins to face Delta's entry into a dynamic equilibrium of tension between viral evolution, immunity of the population associated with the second wave, and the asymmetry of vaccination campaigns and regional health policies. In this review, we present an update of the latest advances regarding the study of these variants, their potential impact on the epidemiological dynamics and vaccine effectiveness, with a special focus on the Latin American situation of the COVID-19 pandemic, in the second half of 2021.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/2886
10.1590/SciELOPreprints.2886
url https://preprints.scielo.org/index.php/scielo/preprint/view/2886
identifier_str_mv 10.1590/SciELOPreprints.2886
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/2886/5099
dc.rights.driver.fl_str_mv Copyright (c) 2021 Carolina Torres, Humberto Debat, Mariana Viegas
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Carolina Torres, Humberto Debat, Mariana Viegas
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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