Obesity, inflammation and pregnancy, a dangerous triad
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | preprint |
Idioma: | spa |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/1200 |
Resumo: | Introduction: Obesity, a common condition during pre-pregnancy and pregnancy, represents a dangerous condition for maternal and child health because of its significant obstetric and perinatal complications. Objective: To describe the pathogenic links between obesity, inflammation and pregnancy. Methods: This literature review was mainly conducted in PubMed Central, SciELO and ClinicalKey, with the descriptors obesity, inflammation and pregnancy. Results: The unfavourable effects of obesity include abortions, gestational diabetes, hypertension, macrosomia, preterm delivery, congenital anomalies and fetal death. In the long term it is also associated with metabolic disorders and diseases in mothers and their offspring. These adverse effects are associated with a state of chronic low-grade inflammation that accompanies excess body weight. Adipose tissue and the placenta play an important role in this inflammatory process with excessive secretion of pro-inflammatory cytokines (TNFα, IL-6, IL-1β, monocyte chemotactic protein 1, serum amyloid protein A) and reduction of anti-inflammatory cytokines. Two mediators such as leptin and adiponectin have crucial roles. Conclusions: Although the mechanisms linking the negative effects of obesity on pregnancy are not well known, it is likely that chronic low-grade inflammation is the main link; therefore, the triad of obesity, inflammation and pregnancy represents a dangerous relationship for maternal-fetal health. |
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Obesity, inflammation and pregnancy, a dangerous triad Obesidad, inflamación y embarazo, una tríada peligrosaObesidade, inflamação e gravidez, uma tríade perigosamaternal obesityinflammationpregnancypregnancy complicationsobesidad maternainflamaciónembarazocomplicaciones del embarazoobesidade maternainflamaçãogravidezcomplicações na gravidezIntroduction: Obesity, a common condition during pre-pregnancy and pregnancy, represents a dangerous condition for maternal and child health because of its significant obstetric and perinatal complications. Objective: To describe the pathogenic links between obesity, inflammation and pregnancy. Methods: This literature review was mainly conducted in PubMed Central, SciELO and ClinicalKey, with the descriptors obesity, inflammation and pregnancy. Results: The unfavourable effects of obesity include abortions, gestational diabetes, hypertension, macrosomia, preterm delivery, congenital anomalies and fetal death. In the long term it is also associated with metabolic disorders and diseases in mothers and their offspring. These adverse effects are associated with a state of chronic low-grade inflammation that accompanies excess body weight. Adipose tissue and the placenta play an important role in this inflammatory process with excessive secretion of pro-inflammatory cytokines (TNFα, IL-6, IL-1β, monocyte chemotactic protein 1, serum amyloid protein A) and reduction of anti-inflammatory cytokines. Two mediators such as leptin and adiponectin have crucial roles. Conclusions: Although the mechanisms linking the negative effects of obesity on pregnancy are not well known, it is likely that chronic low-grade inflammation is the main link; therefore, the triad of obesity, inflammation and pregnancy represents a dangerous relationship for maternal-fetal health.Introducción: La obesidad, un estado común durante la etapa pregestacional y el embarazo, representa una condición peligrosa para la salud materno-infantil por sus notables complicaciones obstétricas y perinatales. Objetivo: Describir los vínculos patogénicos entre obesidad, inflamación y embarazo. Métodos: Esta revisión bibliográfica se realizó principalmente en PubMed Central, SciELO y ClinicalKey, con los descriptores obesity, inflammation y pregnancy. Resultados: Entre los efectos desfavorables de la obesidad se encuentran abortos, diabetes gestacional, hipertensión, macrosomia, parto pretérmino, anomalías congénitas y muerte fetal. A largo plazo se asocia también con trastornos metabólicos y enfermedades en las madres y sus descendientes. Estos efectos desfavorables se relacionan con un estado de inflamación crónica de bajo grado que acompaña el exceso de peso corporal. En este proceso inflamatorio juegan un papel importante el tejido adiposo y la placenta con la secreción excesiva de citoquinas proinflamatorias (TNFα, IL-6, IL-1β, proteína 1 quimiotáctica de monocitos, proteína A amiloide sérico) y la reducción de citoquinas antiinflamatorias. Dos mediadores como leptina y adiponectina tienen papeles cruciales. Conclusiones: Aunque no se conocen bien los mecanismos que vinculan los efectos negativos de la obesidad sobre el embarazo, es probable que la inflamación crónica de bajo grado sea el vínculo principal; por tanto, la tríada obesidad, inflamación y embarazo representa una relación peligrosa para la salud materno-fetal.SciELO PreprintsSciELO PreprintsSciELO Preprints2020-09-10info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/120010.1590/SciELOPreprints.1200spahttps://preprints.scielo.org/index.php/scielo/article/view/1200/1825Copyright (c) 2020 Pedro Enrique Miguel Soca, Gisela Eduarda Feria Díaz, Sonia Noemí González Benítez, María de los Ángeles Leyva Monterohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSoca, Pedro Enrique MiguelDíaz, Gisela Eduarda FeriaBenítez, Sonia Noemí GonzálezMontero, María de los Ángeles Leyvareponame:SciELO Preprintsinstname:SciELOinstacron:SCI2020-09-09T21:25:14Zoai:ops.preprints.scielo.org:preprint/1200Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2020-09-09T21:25:14SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Obesity, inflammation and pregnancy, a dangerous triad Obesidad, inflamación y embarazo, una tríada peligrosa Obesidade, inflamação e gravidez, uma tríade perigosa |
title |
Obesity, inflammation and pregnancy, a dangerous triad |
spellingShingle |
Obesity, inflammation and pregnancy, a dangerous triad Soca, Pedro Enrique Miguel maternal obesity inflammation pregnancy pregnancy complications obesidad materna inflamación embarazo complicaciones del embarazo obesidade materna inflamação gravidez complicações na gravidez |
title_short |
Obesity, inflammation and pregnancy, a dangerous triad |
title_full |
Obesity, inflammation and pregnancy, a dangerous triad |
title_fullStr |
Obesity, inflammation and pregnancy, a dangerous triad |
title_full_unstemmed |
Obesity, inflammation and pregnancy, a dangerous triad |
title_sort |
Obesity, inflammation and pregnancy, a dangerous triad |
author |
Soca, Pedro Enrique Miguel |
author_facet |
Soca, Pedro Enrique Miguel Díaz, Gisela Eduarda Feria Benítez, Sonia Noemí González Montero, María de los Ángeles Leyva |
author_role |
author |
author2 |
Díaz, Gisela Eduarda Feria Benítez, Sonia Noemí González Montero, María de los Ángeles Leyva |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Soca, Pedro Enrique Miguel Díaz, Gisela Eduarda Feria Benítez, Sonia Noemí González Montero, María de los Ángeles Leyva |
dc.subject.por.fl_str_mv |
maternal obesity inflammation pregnancy pregnancy complications obesidad materna inflamación embarazo complicaciones del embarazo obesidade materna inflamação gravidez complicações na gravidez |
topic |
maternal obesity inflammation pregnancy pregnancy complications obesidad materna inflamación embarazo complicaciones del embarazo obesidade materna inflamação gravidez complicações na gravidez |
description |
Introduction: Obesity, a common condition during pre-pregnancy and pregnancy, represents a dangerous condition for maternal and child health because of its significant obstetric and perinatal complications. Objective: To describe the pathogenic links between obesity, inflammation and pregnancy. Methods: This literature review was mainly conducted in PubMed Central, SciELO and ClinicalKey, with the descriptors obesity, inflammation and pregnancy. Results: The unfavourable effects of obesity include abortions, gestational diabetes, hypertension, macrosomia, preterm delivery, congenital anomalies and fetal death. In the long term it is also associated with metabolic disorders and diseases in mothers and their offspring. These adverse effects are associated with a state of chronic low-grade inflammation that accompanies excess body weight. Adipose tissue and the placenta play an important role in this inflammatory process with excessive secretion of pro-inflammatory cytokines (TNFα, IL-6, IL-1β, monocyte chemotactic protein 1, serum amyloid protein A) and reduction of anti-inflammatory cytokines. Two mediators such as leptin and adiponectin have crucial roles. Conclusions: Although the mechanisms linking the negative effects of obesity on pregnancy are not well known, it is likely that chronic low-grade inflammation is the main link; therefore, the triad of obesity, inflammation and pregnancy represents a dangerous relationship for maternal-fetal health. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
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preprint |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/1200 10.1590/SciELOPreprints.1200 |
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https://preprints.scielo.org/index.php/scielo/preprint/view/1200 |
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10.1590/SciELOPreprints.1200 |
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spa |
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spa |
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https://preprints.scielo.org/index.php/scielo/article/view/1200/1825 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints |
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SciELO Preprints - SciELO |
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