The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | preprint |
Idioma: | por |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/45 |
Resumo: | Clinical trials investigating COVID-19 treatments have been carried out worldwide, and also in Brazil. Public registration of research protocols promotes transparency and follows the legislation. Objective: To describe the research protocols under development in Brazil for COVID-19 treatment, and to evaluate the publication after registration in Plataforma Brasil/CONEP. Method: A comprehensive search on the databases ClinicalTrials.gov, ReBEC (Brazilian database) and the International Clinical Trials Registry Platform, was performed on April 11, 2020. The CONEP Bulletin was consulted on April 7, 2020 to assess intervention studies elected for public registration. Results: Our study shows that there are sixteen intervention studies in progress about COVID-19 in Brazil (CONEP registry), however, only six are available in the protocol registry databases. Brazilian open access research protocols investigated interventions with: hydroxychloroquine associated with azithromycin or monotherapy; chloroquine; dexamethasone; mesenchymal stem cells. Five studies (83%) are open and include patients with suspected or confirmed COVID-19 diagnosis. Three studies are multicenter and all include clinically relevant outcomes. Conclusion: Brazil has research protocols in progress for COVID-19 treatment, however only 1/3 of these studies has public protocols available. |
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The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocolsIniciativas brasileiras de estudos de intervenção em andamento para a COVID-19COVID-19Ensaios clínicosBrasilProtocolos ClínicosPesquisa clínicaCOVID-19treatment outcomeBrazilclinical protocolsClinical trials investigating COVID-19 treatments have been carried out worldwide, and also in Brazil. Public registration of research protocols promotes transparency and follows the legislation. Objective: To describe the research protocols under development in Brazil for COVID-19 treatment, and to evaluate the publication after registration in Plataforma Brasil/CONEP. Method: A comprehensive search on the databases ClinicalTrials.gov, ReBEC (Brazilian database) and the International Clinical Trials Registry Platform, was performed on April 11, 2020. The CONEP Bulletin was consulted on April 7, 2020 to assess intervention studies elected for public registration. Results: Our study shows that there are sixteen intervention studies in progress about COVID-19 in Brazil (CONEP registry), however, only six are available in the protocol registry databases. Brazilian open access research protocols investigated interventions with: hydroxychloroquine associated with azithromycin or monotherapy; chloroquine; dexamethasone; mesenchymal stem cells. Five studies (83%) are open and include patients with suspected or confirmed COVID-19 diagnosis. Three studies are multicenter and all include clinically relevant outcomes. Conclusion: Brazil has research protocols in progress for COVID-19 treatment, however only 1/3 of these studies has public protocols available.As pesquisas clínicas relacionadas a COVID-19 estão acontecendo em todo o mundo, inclusive no Brasil. Os registros públicos de protocolos de pesquisa promovem transparência e atendem às regulamentações. Objetivo: Descrever os protocolos de pesquisa em desenvolvimento no Brasil para investigações de alternativas terapêuticas para a COVID-19, e avaliar o cumprimento da publicação após registro na Plataforma Brasil/CONEP. Método: Uma revisão foi realizada nas bases de registro de protocolos de pesquisa: ClinicalTrials.gov, ReBEC (base brasileira) e International Clinical Trials Registry Platform, no dia 11 de abril de 2020. O boletim da CONEP do dia 07 de abril de 2020 foi consultado para avaliar estudos de intervenção passíveis de registro. Resultados: Nosso estudo mostrou que há dezesseis estudos de intervenção sobre a COVID-19 em andamento no Brasil e registrados na CONEP, porém somente seis estão disponíveis nas bases de registro de protocolos. Os protocolos brasileiros de acesso aberto incluíram a investigação de intervenções com: hidroxicloroquina associada a azitromicina ou em monoterapia; cloroquina; dexametasona; células tronco mesenquimais. Cinco estudos (83%) são abertos e incluíram pacientes com suspeita ou diagnóstico confirmado da COVID-19. Três estudos são multicêntricos e todos propõe a avaliação de desfechos clinicamente relevantes. Conclusão: O Brasil tem protocolos de pesquisa em andamento de intervenções terapêuticas na COVID-19, porém apenas 1/3 destes estudos têm protocolos públicos.SciELO PreprintsSciELO PreprintsSciELO Preprints2020-04-14info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/4510.1590/SciELOPreprints.45porhttps://preprints.scielo.org/index.php/scielo/article/view/45/54Copyright (c) 2020 Tatiane Ribeiro, Talita Aona Mazotti, Moacyr R Cuce Nobre , Airton Stein, Daniela Oliveira de Melohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBomfim Ribeiro, TatianeAona Mazotti, TalitaR Cuce Nobre , MoacyrStein, AirtonOliveira de Melo, Danielareponame:SciELO Preprintsinstname:SciELOinstacron:SCI2020-04-14T12:12:22Zoai:ops.preprints.scielo.org:preprint/45Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2020-04-14T12:12:22SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols Iniciativas brasileiras de estudos de intervenção em andamento para a COVID-19 |
title |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
spellingShingle |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols Bomfim Ribeiro, Tatiane COVID-19 Ensaios clínicos Brasil Protocolos Clínicos Pesquisa clínica COVID-19 treatment outcome Brazil clinical protocols |
title_short |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
title_full |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
title_fullStr |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
title_full_unstemmed |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
title_sort |
The Brazilian ongoing intervention studies for COVID-19: Clinical trials protocols |
author |
Bomfim Ribeiro, Tatiane |
author_facet |
Bomfim Ribeiro, Tatiane Aona Mazotti, Talita R Cuce Nobre , Moacyr Stein, Airton Oliveira de Melo, Daniela |
author_role |
author |
author2 |
Aona Mazotti, Talita R Cuce Nobre , Moacyr Stein, Airton Oliveira de Melo, Daniela |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bomfim Ribeiro, Tatiane Aona Mazotti, Talita R Cuce Nobre , Moacyr Stein, Airton Oliveira de Melo, Daniela |
dc.subject.por.fl_str_mv |
COVID-19 Ensaios clínicos Brasil Protocolos Clínicos Pesquisa clínica COVID-19 treatment outcome Brazil clinical protocols |
topic |
COVID-19 Ensaios clínicos Brasil Protocolos Clínicos Pesquisa clínica COVID-19 treatment outcome Brazil clinical protocols |
description |
Clinical trials investigating COVID-19 treatments have been carried out worldwide, and also in Brazil. Public registration of research protocols promotes transparency and follows the legislation. Objective: To describe the research protocols under development in Brazil for COVID-19 treatment, and to evaluate the publication after registration in Plataforma Brasil/CONEP. Method: A comprehensive search on the databases ClinicalTrials.gov, ReBEC (Brazilian database) and the International Clinical Trials Registry Platform, was performed on April 11, 2020. The CONEP Bulletin was consulted on April 7, 2020 to assess intervention studies elected for public registration. Results: Our study shows that there are sixteen intervention studies in progress about COVID-19 in Brazil (CONEP registry), however, only six are available in the protocol registry databases. Brazilian open access research protocols investigated interventions with: hydroxychloroquine associated with azithromycin or monotherapy; chloroquine; dexamethasone; mesenchymal stem cells. Five studies (83%) are open and include patients with suspected or confirmed COVID-19 diagnosis. Three studies are multicenter and all include clinically relevant outcomes. Conclusion: Brazil has research protocols in progress for COVID-19 treatment, however only 1/3 of these studies has public protocols available. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
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preprint |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/45 10.1590/SciELOPreprints.45 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/45 |
identifier_str_mv |
10.1590/SciELOPreprints.45 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/45/54 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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