“Incidentalormones” - Macro-hormones
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | preprint |
Idioma: | eng |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/1734 |
Resumo: | Introduction: Complexes of monomeric hormone molecules immunoglobulin-associated lead to the formation of macro-complexes biologically inactive that are called macro-hormones. Patients’ presenting unexpectedly elevated hormones values indicates the need that the existence of macro-hormones must be researched. Objective: To describe the macro-hormones discovered incidentally in laboratory tests, which we refer to as "incidentalormones". Methods: An integrative review was conducted, and data was gathered from the published articles in medical database. The different forms of macro-hormones are reviewed; the biochemical significance and laboratory assays of macro-hormones are also revised within the ambit of current laboratory medicine. We discussed diagnostic difficulty encountered in patients with "incidentalormones”, as well as methods of macro-hormone detection, immunoglobulin involved, clinical significance and associations with other diseases. Conclusion: The presence of macro-hormones, often guides us to intervention in laboratory trials, and could result in false-positive diagnosis with inadequate therapy. Laboratories should follow a diagnostic algorithm to carefully recognize and examine possible immunoassay interferences. |
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“Incidentalormones” - Macro-hormonesMacro-hormonesmacro-complexesinactive hormonesimmunoassaysIntroduction: Complexes of monomeric hormone molecules immunoglobulin-associated lead to the formation of macro-complexes biologically inactive that are called macro-hormones. Patients’ presenting unexpectedly elevated hormones values indicates the need that the existence of macro-hormones must be researched. Objective: To describe the macro-hormones discovered incidentally in laboratory tests, which we refer to as "incidentalormones". Methods: An integrative review was conducted, and data was gathered from the published articles in medical database. The different forms of macro-hormones are reviewed; the biochemical significance and laboratory assays of macro-hormones are also revised within the ambit of current laboratory medicine. We discussed diagnostic difficulty encountered in patients with "incidentalormones”, as well as methods of macro-hormone detection, immunoglobulin involved, clinical significance and associations with other diseases. Conclusion: The presence of macro-hormones, often guides us to intervention in laboratory trials, and could result in false-positive diagnosis with inadequate therapy. Laboratories should follow a diagnostic algorithm to carefully recognize and examine possible immunoassay interferences.SciELO PreprintsSciELO PreprintsSciELO Preprints2021-02-08info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/173410.1590/SciELOPreprints.1734enghttps://preprints.scielo.org/index.php/scielo/article/view/1734/2765Copyright (c) 2021 Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessde Oliveira Andrade, Luis JesuinoMatos de Oliveira, Gabriela Correia reponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-01-19T01:44:35Zoai:ops.preprints.scielo.org:preprint/1734Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-01-19T01:44:35SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
“Incidentalormones” - Macro-hormones |
title |
“Incidentalormones” - Macro-hormones |
spellingShingle |
“Incidentalormones” - Macro-hormones de Oliveira Andrade, Luis Jesuino Macro-hormones macro-complexes inactive hormones immunoassays |
title_short |
“Incidentalormones” - Macro-hormones |
title_full |
“Incidentalormones” - Macro-hormones |
title_fullStr |
“Incidentalormones” - Macro-hormones |
title_full_unstemmed |
“Incidentalormones” - Macro-hormones |
title_sort |
“Incidentalormones” - Macro-hormones |
author |
de Oliveira Andrade, Luis Jesuino |
author_facet |
de Oliveira Andrade, Luis Jesuino Matos de Oliveira, Gabriela Correia |
author_role |
author |
author2 |
Matos de Oliveira, Gabriela Correia |
author2_role |
author |
dc.contributor.author.fl_str_mv |
de Oliveira Andrade, Luis Jesuino Matos de Oliveira, Gabriela Correia |
dc.subject.por.fl_str_mv |
Macro-hormones macro-complexes inactive hormones immunoassays |
topic |
Macro-hormones macro-complexes inactive hormones immunoassays |
description |
Introduction: Complexes of monomeric hormone molecules immunoglobulin-associated lead to the formation of macro-complexes biologically inactive that are called macro-hormones. Patients’ presenting unexpectedly elevated hormones values indicates the need that the existence of macro-hormones must be researched. Objective: To describe the macro-hormones discovered incidentally in laboratory tests, which we refer to as "incidentalormones". Methods: An integrative review was conducted, and data was gathered from the published articles in medical database. The different forms of macro-hormones are reviewed; the biochemical significance and laboratory assays of macro-hormones are also revised within the ambit of current laboratory medicine. We discussed diagnostic difficulty encountered in patients with "incidentalormones”, as well as methods of macro-hormone detection, immunoglobulin involved, clinical significance and associations with other diseases. Conclusion: The presence of macro-hormones, often guides us to intervention in laboratory trials, and could result in false-positive diagnosis with inadequate therapy. Laboratories should follow a diagnostic algorithm to carefully recognize and examine possible immunoassay interferences. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/1734 10.1590/SciELOPreprints.1734 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/1734 |
identifier_str_mv |
10.1590/SciELOPreprints.1734 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/1734/2765 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
dc.source.none.fl_str_mv |
reponame:SciELO Preprints instname:SciELO instacron:SCI |
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SciELO |
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SCI |
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SCI |
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SciELO Preprints |
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SciELO Preprints |
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SciELO Preprints - SciELO |
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scielo.submission@scielo.org |
_version_ |
1797047821537378304 |