CORRELATION OF BLOOD AND SALIVARY TROPONIN IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: PRELIMINARY STUDY

• Autor(a) principal: Arsego, Flávia Kubrusly
• Data de Publicação: 2024
• Outros Autores: Kubrusly, Luiz Fernando, Gewehr, Douglas Mesadri, Possiedi , Rafael Dib, Nassif , Paulo Afonso Nunes, Tabushi , Fernando Issamu, Kubrusly , Fernando Bermudez, Ronkoski , Maria Luiza, Cioato , Priscila Panassolo
• Tipo de documento: preprint
• Idioma: eng
• Título da fonte: SciELO Preprints
• Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/8347
• topic: Troponina I; Troponina T; Infarto agudo do miocárdio; Troponin I; Troponin T; Acute myocardial infarction

Introduction: In the event of myocardial injury, the identification of biomarkers that constitute the cardiac muscle cell, especially troponins, can be observed from blood and saliva samples. The preference for using saliva as a diagnostic fluid is supported by the ease of obtaining it using a non-invasive and potentially pre-hospital method. Objective: To verify the expression of troponin I in salivary fluid in acute myocardial infarction in emergency and pre-hospital screenings and correlate it with plasma troponin I levels. Method: Cross-sectional analytical study of diagnostic testing in 27 patients, 9 women and 18 men, with diagnostic confirmation of acute myocardial infarction. Blood and saliva samples were collected and stored and transported over a period of up to 24 hours for troponina I quantification. Results: The study demonstrated that 44.4% of patients were positive for troponin I in both analyses, with equal dichotomous results in 48.1% of cases. Thus, the salivary troponin test achieved 48% sensitivity and 50% specificity. Conclusion: It was possible to identify troponin in the saliva fluid of patients suffering from acute myocardial infarction, but the probability of a false positive result was 50% and a false negative result was 52%.