Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | preprint |
Idioma: | spa |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/2984 |
Resumo: | Objective: to establish the magnitude and risk factors for SARS-CoV-2 infection in the District of General Pueyrredón, Buenos Aires, Argentina: the INECOVID study. Methodology: a prospective cohort was designed with participants from the District general population. The follow-up period was from June 22 to December 18, 2020, with a minimum appointment interval of 21 days. Data were obtained via questionnaires and serum or plasma samples. The primary event was considered as the time through seroconversion as evidence of SARS-CoV-2 infection. The accumulated risk of infection was estimated using the Kaplan Meier method. Cox models were built with time-dependent variables. Results: 345 participants were recruited (n = 222 women, 64.3%; 123 men, 35.7%), with a median age of 45 years in women (Interquartile range: 19) and 49 in men (Interquartile range: 26). 12.8% of participants (n = 44) had evidence of SARS-CoV-2 infection [incidence density of 9.1 cases (women: 11.1, men: 5.1) per 10,000 person-day]. 36.4% of the cases (n=16) were asymptomatic. The following factors were associated to the risk of infection: being a close contact of a confirmed COVID-19 case (HR=5,56; IC95% 2,85-10,83), being a health worker (HR=2,93; IC95% 1,55-5,52), living in crowded conditions (HR= 2,23; IC95% 1,13-4,49) and age (HR= 0,98; IC95% 0,95-1,00). Conclusion: the identified risk factors endorse the protection policies and protocols adopted by the Argentinian sanitary authorities for the general population and the care programs for health workers in the pre-vaccination phase. |
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Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factorsEstudio de cohortes prospectivo en etapa temprana de la pandemia COVID-19, Partido de General Pueyrredón, Argentina (INECOVID): dinámica de infección y factores de riesgoCoronavirus InfectionsCohort StudiesRisk FactorsEpidemiologyInfecciones por CoronavirusEstudios de CohortesFactores de RiesgoEpidemiologíaObjective: to establish the magnitude and risk factors for SARS-CoV-2 infection in the District of General Pueyrredón, Buenos Aires, Argentina: the INECOVID study. Methodology: a prospective cohort was designed with participants from the District general population. The follow-up period was from June 22 to December 18, 2020, with a minimum appointment interval of 21 days. Data were obtained via questionnaires and serum or plasma samples. The primary event was considered as the time through seroconversion as evidence of SARS-CoV-2 infection. The accumulated risk of infection was estimated using the Kaplan Meier method. Cox models were built with time-dependent variables. Results: 345 participants were recruited (n = 222 women, 64.3%; 123 men, 35.7%), with a median age of 45 years in women (Interquartile range: 19) and 49 in men (Interquartile range: 26). 12.8% of participants (n = 44) had evidence of SARS-CoV-2 infection [incidence density of 9.1 cases (women: 11.1, men: 5.1) per 10,000 person-day]. 36.4% of the cases (n=16) were asymptomatic. The following factors were associated to the risk of infection: being a close contact of a confirmed COVID-19 case (HR=5,56; IC95% 2,85-10,83), being a health worker (HR=2,93; IC95% 1,55-5,52), living in crowded conditions (HR= 2,23; IC95% 1,13-4,49) and age (HR= 0,98; IC95% 0,95-1,00). Conclusion: the identified risk factors endorse the protection policies and protocols adopted by the Argentinian sanitary authorities for the general population and the care programs for health workers in the pre-vaccination phase.Objetivo: establecer la magnitud y los factores de riesgo de infección por SARS-CoV-2 en el Partido de General Pueyrredón, Buenos Aires, Argentina: estudio INECOVID. Métodos: diseño de cohortes prospectivo con participantes de población general del partido. El período de seguimiento fue del 22 de junio al 18 de diciembre de 2020, con un intervalo mínimo de citación de 21 días. Los datos se obtuvieron mediante cuestionarios y muestras de suero o plasma. El evento primario fue el tiempo hasta la seroconversión (IgG) como evidencia de infección por SARS-CoV-2. Se estimó el riesgo acumulado de infección por el método de Kaplan Meier. Se construyeron modelos de Cox con variables tiempo-dependientes. Resultados: fueron reclutados 345 participantes (n=222 mujeres, 64,3%; 123 varones, 35,7%), con una edad mediana de 45 años en mujeres (Rango intercuartílico: 19) y 49 en varones (Rango intercuartílico: 26). El 12,8% de los participantes (n=44) tuvo evidencia de infección por SARS-CoV-2 [densidad de incidencia de 9,1 casos (mujeres: 11,1, varones: 5,1) por 10.000 días-persona]. El 36,4% de los casos (n=16) fue asintomático. Se mostraron asociados al riesgo de infección: ser contacto estrecho de un caso confirmado de COVID-19 (HR=5,56; IC95% 2,85-10,83), ser trabajador de salud (HR=2,93; IC95% 1,55-5,52), vivir en hacinamiento (HR= 2,23; IC95% 1,13-4,49) y edad (HR= 0,98; IC95% 0,95-1,00). Conclusión: los factores de riesgo de infección hallados avalan las políticas y protocolos de protección adoptadas por las autoridades sanitarias de Argentina para población general y los programas de cuidado de los trabajadores de salud en la etapa pre-vacunación.SciELO PreprintsSciELO PreprintsSciELO Preprints2021-09-23info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/298410.1590/1980-549720210055spahttps://preprints.scielo.org/index.php/scielo/article/view/2984/5312Copyright (c) 2021 Jimena Marro, Christian Ballejo, María Fernanda Aguirre, María Eugenia de San Martín, Lucía López Miranda, Verónica Poncet, Andrea Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMarro, Jimena Ballejo, Christian Aguirre, María Fernanda San Martín, María Eugenia de Miranda, Lucía López Poncet, Verónica Silva, Andrea reponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-09-23T17:46:36Zoai:ops.preprints.scielo.org:preprint/2984Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-09-23T17:46:36SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors Estudio de cohortes prospectivo en etapa temprana de la pandemia COVID-19, Partido de General Pueyrredón, Argentina (INECOVID): dinámica de infección y factores de riesgo |
title |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
spellingShingle |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors Marro, Jimena Coronavirus Infections Cohort Studies Risk Factors Epidemiology Infecciones por Coronavirus Estudios de Cohortes Factores de Riesgo Epidemiología |
title_short |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
title_full |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
title_fullStr |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
title_full_unstemmed |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
title_sort |
Prospective cohort study in the early stage of the COVID-19 pandemic, District of General Pueyrredón, Argentina (INECOVID): infection dynamics and risk factors |
author |
Marro, Jimena |
author_facet |
Marro, Jimena Ballejo, Christian Aguirre, María Fernanda San Martín, María Eugenia de Miranda, Lucía López Poncet, Verónica Silva, Andrea |
author_role |
author |
author2 |
Ballejo, Christian Aguirre, María Fernanda San Martín, María Eugenia de Miranda, Lucía López Poncet, Verónica Silva, Andrea |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Marro, Jimena Ballejo, Christian Aguirre, María Fernanda San Martín, María Eugenia de Miranda, Lucía López Poncet, Verónica Silva, Andrea |
dc.subject.por.fl_str_mv |
Coronavirus Infections Cohort Studies Risk Factors Epidemiology Infecciones por Coronavirus Estudios de Cohortes Factores de Riesgo Epidemiología |
topic |
Coronavirus Infections Cohort Studies Risk Factors Epidemiology Infecciones por Coronavirus Estudios de Cohortes Factores de Riesgo Epidemiología |
description |
Objective: to establish the magnitude and risk factors for SARS-CoV-2 infection in the District of General Pueyrredón, Buenos Aires, Argentina: the INECOVID study. Methodology: a prospective cohort was designed with participants from the District general population. The follow-up period was from June 22 to December 18, 2020, with a minimum appointment interval of 21 days. Data were obtained via questionnaires and serum or plasma samples. The primary event was considered as the time through seroconversion as evidence of SARS-CoV-2 infection. The accumulated risk of infection was estimated using the Kaplan Meier method. Cox models were built with time-dependent variables. Results: 345 participants were recruited (n = 222 women, 64.3%; 123 men, 35.7%), with a median age of 45 years in women (Interquartile range: 19) and 49 in men (Interquartile range: 26). 12.8% of participants (n = 44) had evidence of SARS-CoV-2 infection [incidence density of 9.1 cases (women: 11.1, men: 5.1) per 10,000 person-day]. 36.4% of the cases (n=16) were asymptomatic. The following factors were associated to the risk of infection: being a close contact of a confirmed COVID-19 case (HR=5,56; IC95% 2,85-10,83), being a health worker (HR=2,93; IC95% 1,55-5,52), living in crowded conditions (HR= 2,23; IC95% 1,13-4,49) and age (HR= 0,98; IC95% 0,95-1,00). Conclusion: the identified risk factors endorse the protection policies and protocols adopted by the Argentinian sanitary authorities for the general population and the care programs for health workers in the pre-vaccination phase. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
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preprint |
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https://preprints.scielo.org/index.php/scielo/preprint/view/2984 10.1590/1980-549720210055 |
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https://preprints.scielo.org/index.php/scielo/preprint/view/2984 |
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10.1590/1980-549720210055 |
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https://preprints.scielo.org/index.php/scielo/article/view/2984/5312 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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