Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | preprint |
Idioma: | por |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/5252 |
Resumo: | Objective: to compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, with the National Health Survey, 2014-2015, composed of 8,952 individuals. 234 adults constituted the sample with SCT. The RI of adults with and without SCT were compared in the study “Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenlfed et al. (2019). The parametric method was used and Student's t test for comparison (p≤0.05). Results: There were statistically significant differences between RI of adults with and without SCT in men and women for hemoglobin, MCV, HCM, CHCM, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, HCM, CHCM, mean platelet volume and RDW in women; Between 18 to 59 years, for HCM, MCV, CHCM, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown races for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, HCM, CHCM, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and research to support the proper management of this condition in Brazil. |
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Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey Diferenças entre intervalos de referência de hemograma de adultos brasileiros com e sem traço falciforme segundo os exames laboratoriais da Pesquisa Nacional de SaúdeInquéritos epidemiológicosValores de ReferênciaContagem de Células SanguíneasTraço FalciformeBrasilHealth SurveysReference ValuesBlood Cell CountSickle Cell TraitBrazilObjective: to compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, with the National Health Survey, 2014-2015, composed of 8,952 individuals. 234 adults constituted the sample with SCT. The RI of adults with and without SCT were compared in the study “Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenlfed et al. (2019). The parametric method was used and Student's t test for comparison (p≤0.05). Results: There were statistically significant differences between RI of adults with and without SCT in men and women for hemoglobin, MCV, HCM, CHCM, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, HCM, CHCM, mean platelet volume and RDW in women; Between 18 to 59 years, for HCM, MCV, CHCM, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown races for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, HCM, CHCM, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and research to support the proper management of this condition in Brazil.Objetivo: comparar intervalos de referência (IR) de hemograma de adultos brasileiros com e sem traço falciforme (HbAS). Métodos: Estudo transversal, com a base de dados da Pesquisa Nacional de Saúde, entre 2014-2015, composta por 8.952 indivíduos. 234 adultos constituíram a amostra com HbAS Comparou-se IR de adultos com e os sem HbAS do estudo “Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde”, de Rosenlfed e colaboradores (2019). Utilizaram-se o método paramétrico para estabelecer os IR e o teste t de Student para comparação (p≤0,05). Resultados: Houve diferenças estatisticamente significativas entre IR de adultos com e sem HbAS nos homens e mulheres para hemoglobina, VCM, HCM, CHCM, glóbulos brancos, linfócitos absolutos, volume plaquetário médio e RDW; Em todas as idades, para glóbulos brancos e RDW nos homens e para VCM, HCM, CHCM, volume plaquetário médio e RDW nas mulheres; Entre 18 a 59 anos, para HCM, VCM, CHCM, neutrófilos, linfócitos e plaquetas nos homens e nas mulheres para linfócitos, glóbulos vermelhos, glóbulos brancos, neutrófilos, eosinófilos, monócitos e plaquetas; A partir de 60 anos, para hemoglobina e hematócrito nos homens e nas mulheres para hematócrito, glóbulos brancos, neutrófilos e plaquetas; Nas raças branca, preta e parda para glóbulos brancos, neutrófilos e plaquetas (p<0,05). Conclusão: Adultos brasileiros com HbAS tiveram menores contagens de hemoglobina, VCM, HCM, CHCM, glóbulos brancos e maiores de RDW que sem HbAS. Os resultados mostram a importância do aconselhamento genético e pesquisas para subsidiar o manejo adequado desta condição no Brasil.SciELO PreprintsSciELO PreprintsSciELO Preprints2022-12-16info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/525210.1590/1980-549720230003.supl.1.1porhttps://preprints.scielo.org/index.php/scielo/article/view/5252/10184Copyright (c) 2022 Ana Carolina Micheletti Gomide Nogueira de Sá, Alanna Gomes da Silva, Crizian Saar Gomes, Antonio Tolentino Nogueira de Sá, Deborah Carvalho Maltahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSá, Ana Carolina Micheletti Gomide Nogueira deSilva, Alanna Gomes daGomes, Crizian SaarSá, Antonio Tolentino Nogueira deMalta, Deborah Carvalhoreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2022-12-16T12:47:32Zoai:ops.preprints.scielo.org:preprint/5252Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2022-12-16T12:47:32SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey Diferenças entre intervalos de referência de hemograma de adultos brasileiros com e sem traço falciforme segundo os exames laboratoriais da Pesquisa Nacional de Saúde |
title |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
spellingShingle |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey Sá, Ana Carolina Micheletti Gomide Nogueira de Inquéritos epidemiológicos Valores de Referência Contagem de Células Sanguíneas Traço Falciforme Brasil Health Surveys Reference Values Blood Cell Count Sickle Cell Trait Brazil |
title_short |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
title_full |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
title_fullStr |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
title_full_unstemmed |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
title_sort |
Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey |
author |
Sá, Ana Carolina Micheletti Gomide Nogueira de |
author_facet |
Sá, Ana Carolina Micheletti Gomide Nogueira de Silva, Alanna Gomes da Gomes, Crizian Saar Sá, Antonio Tolentino Nogueira de Malta, Deborah Carvalho |
author_role |
author |
author2 |
Silva, Alanna Gomes da Gomes, Crizian Saar Sá, Antonio Tolentino Nogueira de Malta, Deborah Carvalho |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sá, Ana Carolina Micheletti Gomide Nogueira de Silva, Alanna Gomes da Gomes, Crizian Saar Sá, Antonio Tolentino Nogueira de Malta, Deborah Carvalho |
dc.subject.por.fl_str_mv |
Inquéritos epidemiológicos Valores de Referência Contagem de Células Sanguíneas Traço Falciforme Brasil Health Surveys Reference Values Blood Cell Count Sickle Cell Trait Brazil |
topic |
Inquéritos epidemiológicos Valores de Referência Contagem de Células Sanguíneas Traço Falciforme Brasil Health Surveys Reference Values Blood Cell Count Sickle Cell Trait Brazil |
description |
Objective: to compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, with the National Health Survey, 2014-2015, composed of 8,952 individuals. 234 adults constituted the sample with SCT. The RI of adults with and without SCT were compared in the study “Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenlfed et al. (2019). The parametric method was used and Student's t test for comparison (p≤0.05). Results: There were statistically significant differences between RI of adults with and without SCT in men and women for hemoglobin, MCV, HCM, CHCM, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, HCM, CHCM, mean platelet volume and RDW in women; Between 18 to 59 years, for HCM, MCV, CHCM, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown races for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, HCM, CHCM, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and research to support the proper management of this condition in Brazil. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/5252 10.1590/1980-549720230003.supl.1.1 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/5252 |
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10.1590/1980-549720230003.supl.1.1 |
dc.language.iso.fl_str_mv |
por |
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por |
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https://preprints.scielo.org/index.php/scielo/article/view/5252/10184 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints - SciELO |
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