Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | preprint |
Idioma: | spa |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/1634 |
Resumo: | Aim: To evaluate the persistence of IgG antibodies to SARS-CoV2, in health workers of the public subsector of the Province of Buenos Aires, and correlate it with demographic variables (sex, age) and other health indicators (diagnosis of COVID-19, comorbidities and pregnancy). Methodology: Descriptive, observational, cross-sectional study. Health workers with a positive result in a first sample (N = 388) underwent a second test to evaluate the persistence of antibodies by ELISA. Results: Of the 386 people evaluated with a conclusive result, 296 had a first positive result between 30 and 90 days before the second test, of these, 90% had detectable antibodies. In those with a positive result more than 90 days ago (45), a significant decrease in persistence of 26.7% was observed. There were no significant associations between demographic and health variables and the second test result. Conclusion: Antibodies remain detectable for at least 90 days in 90% of the cases analyzed. It is main to continue this study over time to have a major period of time between tests. The information shown here throws interesting and promising data regarding the possible protection of new COVID-19 infections in personnel with high risk exposure. This evidence could contribute to decision-making, both at the local and regional level, for the adequate vaccination planning, as well as for the management in the event of a possible second wave scenario of COVID-19 pandemic in Latin America. |
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Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos AiresPersistencia de anticuerpos IgG contra SARS-CoV2 en personal de salud - provincia de Buenos Aires.Estudios seroepidemiológicosAnticuerposFuerza Laboral en SaludInfecciones por CoronavirusSeroepidemiologic StudiesCoronavirus Infections AntibodiesHealth WorkforceAim: To evaluate the persistence of IgG antibodies to SARS-CoV2, in health workers of the public subsector of the Province of Buenos Aires, and correlate it with demographic variables (sex, age) and other health indicators (diagnosis of COVID-19, comorbidities and pregnancy). Methodology: Descriptive, observational, cross-sectional study. Health workers with a positive result in a first sample (N = 388) underwent a second test to evaluate the persistence of antibodies by ELISA. Results: Of the 386 people evaluated with a conclusive result, 296 had a first positive result between 30 and 90 days before the second test, of these, 90% had detectable antibodies. In those with a positive result more than 90 days ago (45), a significant decrease in persistence of 26.7% was observed. There were no significant associations between demographic and health variables and the second test result. Conclusion: Antibodies remain detectable for at least 90 days in 90% of the cases analyzed. It is main to continue this study over time to have a major period of time between tests. The information shown here throws interesting and promising data regarding the possible protection of new COVID-19 infections in personnel with high risk exposure. This evidence could contribute to decision-making, both at the local and regional level, for the adequate vaccination planning, as well as for the management in the event of a possible second wave scenario of COVID-19 pandemic in Latin America.Objetivo: evaluar la persistencia de los anticuerpos IgG contra SARS-CoV2, en trabajadores de salud del subsector público de la Provincia de Buenos Aires, y correlacionarla con variables demográficas (sexo, edad) y otros indicadores de salud (diagnóstico de COVID-19, comorbilidades y embarazo). Metodología: Estudio descriptivo, observacional, de corte transversal. Al personal de salud con un resultado positivo en una primera muestra (N=388) se les realizó una segunda prueba para evaluar la persistencia de anticuerpos mediante ELISA. Resultados: De las 386 personas evaluadas con resultado concluyente, 296 contaban con un primer resultado positivo entre los 30 y los 90 días anteriores a la segunda prueba, el 90% presentó anticuerpos detectables. En aquellas personas con un resultado positivo hacía más de 90 días (45) se observó una caída significativa en la persistencia del 26,7%. No hubo asociaciones significativas entre las variables demográficas y de salud y el resultado de la segunda prueba. Conclusión: Los anticuerpos se mantienen detectables por al menos 90 días en el 90% de los casos analizados. Resulta fundamental continuar este estudio en el tiempo para contar con un período de tiempo mayor entre pruebas. La información aquí mostrada arroja datos interesantes y prometedores en cuanto a la posible protección de nuevos contagios de COVID-19 en personal con alta exposición de riesgo. Estas evidencias podrían contribuir a la toma de decisiones, tanto a nivel local como regional, para la adecuada planificación de la vacunación, así como también, para el manejo de la pandemia ante una posible segunda ola de casos en América Latina.SciELO PreprintsSciELO PreprintsSciELO Preprints2020-12-30info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/163410.1590/SciELOPreprints.1634spahttps://preprints.scielo.org/index.php/scielo/article/view/1634/2635Copyright (c) 2020 Marina Pifano, Laura Fischerman, Regina Ercole, Laura Muñoz, Nicolas Kreplak, Enio Garcia, Yamila Comes, Rosa Bolognahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPifano, Marina Fischerman, LauraErcole, Regina Muñoz, LauraKreplak, NicolasGarcia, EnioComes, YamilaBologna, Rosareponame:SciELO Preprintsinstname:SciELOinstacron:SCI2020-12-18T17:03:53Zoai:ops.preprints.scielo.org:preprint/1634Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2020-12-18T17:03:53SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires Persistencia de anticuerpos IgG contra SARS-CoV2 en personal de salud - provincia de Buenos Aires. |
title |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
spellingShingle |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires Pifano, Marina Estudios seroepidemiológicos Anticuerpos Fuerza Laboral en Salud Infecciones por Coronavirus Seroepidemiologic Studies Coronavirus Infections Antibodies Health Workforce |
title_short |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
title_full |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
title_fullStr |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
title_full_unstemmed |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
title_sort |
Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires |
author |
Pifano, Marina |
author_facet |
Pifano, Marina Fischerman, Laura Ercole, Regina Muñoz, Laura Kreplak, Nicolas Garcia, Enio Comes, Yamila Bologna, Rosa |
author_role |
author |
author2 |
Fischerman, Laura Ercole, Regina Muñoz, Laura Kreplak, Nicolas Garcia, Enio Comes, Yamila Bologna, Rosa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Pifano, Marina Fischerman, Laura Ercole, Regina Muñoz, Laura Kreplak, Nicolas Garcia, Enio Comes, Yamila Bologna, Rosa |
dc.subject.por.fl_str_mv |
Estudios seroepidemiológicos Anticuerpos Fuerza Laboral en Salud Infecciones por Coronavirus Seroepidemiologic Studies Coronavirus Infections Antibodies Health Workforce |
topic |
Estudios seroepidemiológicos Anticuerpos Fuerza Laboral en Salud Infecciones por Coronavirus Seroepidemiologic Studies Coronavirus Infections Antibodies Health Workforce |
description |
Aim: To evaluate the persistence of IgG antibodies to SARS-CoV2, in health workers of the public subsector of the Province of Buenos Aires, and correlate it with demographic variables (sex, age) and other health indicators (diagnosis of COVID-19, comorbidities and pregnancy). Methodology: Descriptive, observational, cross-sectional study. Health workers with a positive result in a first sample (N = 388) underwent a second test to evaluate the persistence of antibodies by ELISA. Results: Of the 386 people evaluated with a conclusive result, 296 had a first positive result between 30 and 90 days before the second test, of these, 90% had detectable antibodies. In those with a positive result more than 90 days ago (45), a significant decrease in persistence of 26.7% was observed. There were no significant associations between demographic and health variables and the second test result. Conclusion: Antibodies remain detectable for at least 90 days in 90% of the cases analyzed. It is main to continue this study over time to have a major period of time between tests. The information shown here throws interesting and promising data regarding the possible protection of new COVID-19 infections in personnel with high risk exposure. This evidence could contribute to decision-making, both at the local and regional level, for the adequate vaccination planning, as well as for the management in the event of a possible second wave scenario of COVID-19 pandemic in Latin America. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/1634 10.1590/SciELOPreprints.1634 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/1634 |
identifier_str_mv |
10.1590/SciELOPreprints.1634 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/1634/2635 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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SCI |
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SciELO Preprints |
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SciELO Preprints |
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SciELO Preprints - SciELO |
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