THERAPEUTIC POTENTIAL OF VITAMIN D IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW

• Autor(a) principal: Juciele da Rocha, Marcia
• Data de Publicação: 2023
• Outros Autores: Mroginski Weber, Douglas, Carvalho Nogueira, Amanda, de Matos Teixeira, Anna Felícia, Moreira Dias Costa Borges, Bárbara, da Silva Bezerra, Fernanda, da Silva Lima, Flávia
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Enfermagem Atual In Derme
• Texto Completo: https://revistaenfermagematual.com/index.php/revista/article/view/1484
• topic: Insuficiência Renal Crônica; Vitamina D; Tratamento Conservador; Nefrologia; Revisão Sistemática; Renal Insufficiency, Chronic; Vitamin D; Conservative Treatment; Nephrology; Systematic Review; Insuficiencia Renal Crónica; Vitamina D; Tratamento Conservador; Nefrología; Revisión Sistemática

Objective: To evaluate the therapeutic potential of vitamin D and its analogues in patients with CKD. Method: This is a systematic review, according to the steps proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The SciELO, Medline, PubMed and LILACS databases were used to gather the articles. The methodological quality of the research was assessed using the Jadad and Newcastle-Ottawa (NOS) method. Results: An initial 132 articles were identified, of which 5 were selected for review meeting all eligibility criteria. The results indicated that the use of vitamin D as drug therapy in patients with CKD contributed to improve the endothelial function of vessels by decreasing vascular stiffness, showed protective action against infections through immunomodulation, decreased parathyroid hormone (PTH) and stabilization of glomerular filtration rate (GFR). Final Considerations: In this sense, it can be concluded that vitamin D becomes a therapeutic agent for multiple tissues contributing to the quality of life of patients with CKD.