Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Paulista de Pediatria (Ed. Português. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100050 |
Resumo: | Objective: To evaluate obese children and adolescents' retinol plasma levels and to correlate them with metabolic syndrome components.Methods: Cross-sectional study with 61 obese children and adolescents (body mass index Z score - ZBMI>+2). Pubertal development, arterial blood pressure, body weight and height for nutritional classification and waist circumference were obtained. A 15mL blood sample was collected (after a 12-hour fasting in a low luminosity room) for retinol determination (cut-off inadequate if <30µg/dL), lipid profile (HDL-c, LDL-c, and triglycerides), oral glucose tolerance test (fasting and 120 minutes) and for high sensitivity C-reactive protein. Spearman correlation and multiple linear regression were used in the statistical analysis.Results: Mean age was 10.7±2.7 years. There was a predominance of male gender 38/61 (62%) and pre-pubertal 35/61 (57%) subjects. The average plasmatic retinol was 48.5±18.6ug/dL. Retinol deficiency and severe obesity were observed in 6/61 (10%) and 36/61 (59%), respectively. Glucose level at 120 minutes was the independent and predictive variable of plasma retinol levels [β=-0.286 (95%CI -0.013 - -0.001)].Conclusions: An independent and inverse association between plasma retinol levels and glucose tolerance was observed, suggesting an important contribution of this vitamin in the morbidities associated to obesity in children and adolescents. |
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Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome componentsvitamin Aobesityglucose metabolism disorderschildadolescentObjective: To evaluate obese children and adolescents' retinol plasma levels and to correlate them with metabolic syndrome components.Methods: Cross-sectional study with 61 obese children and adolescents (body mass index Z score - ZBMI>+2). Pubertal development, arterial blood pressure, body weight and height for nutritional classification and waist circumference were obtained. A 15mL blood sample was collected (after a 12-hour fasting in a low luminosity room) for retinol determination (cut-off inadequate if <30µg/dL), lipid profile (HDL-c, LDL-c, and triglycerides), oral glucose tolerance test (fasting and 120 minutes) and for high sensitivity C-reactive protein. Spearman correlation and multiple linear regression were used in the statistical analysis.Results: Mean age was 10.7±2.7 years. There was a predominance of male gender 38/61 (62%) and pre-pubertal 35/61 (57%) subjects. The average plasmatic retinol was 48.5±18.6ug/dL. Retinol deficiency and severe obesity were observed in 6/61 (10%) and 36/61 (59%), respectively. Glucose level at 120 minutes was the independent and predictive variable of plasma retinol levels [β=-0.286 (95%CI -0.013 - -0.001)].Conclusions: An independent and inverse association between plasma retinol levels and glucose tolerance was observed, suggesting an important contribution of this vitamin in the morbidities associated to obesity in children and adolescents.Sociedade de Pediatria de São Paulo2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100050Revista Paulista de Pediatria v.32 n.1 2014reponame:Revista Paulista de Pediatria (Ed. Português. Online)instname:Sociedade de Pediatria de São Paulo (SPSP)instacron:SPSP10.1590/S0103-05822014000100009info:eu-repo/semantics/openAccessTeske,MárciaMelges,Ana Paula B.Souza,Fabíola Isabel S. deFonseca,Fernando Luiz A.Sarni,Roseli Oselka S.eng2015-09-01T00:00:00Zoai:scielo:S0103-05822014000100050Revistahttps://www.rpped.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.phppediatria@spsp.org.br||rpp@spsp.org.br1984-04620103-0582opendoar:2015-09-01T00:00Revista Paulista de Pediatria (Ed. Português. Online) - Sociedade de Pediatria de São Paulo (SPSP)false |
dc.title.none.fl_str_mv |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
title |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
spellingShingle |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components Teske,Márcia vitamin A obesity glucose metabolism disorders child adolescent |
title_short |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
title_full |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
title_fullStr |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
title_full_unstemmed |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
title_sort |
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components |
author |
Teske,Márcia |
author_facet |
Teske,Márcia Melges,Ana Paula B. Souza,Fabíola Isabel S. de Fonseca,Fernando Luiz A. Sarni,Roseli Oselka S. |
author_role |
author |
author2 |
Melges,Ana Paula B. Souza,Fabíola Isabel S. de Fonseca,Fernando Luiz A. Sarni,Roseli Oselka S. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Teske,Márcia Melges,Ana Paula B. Souza,Fabíola Isabel S. de Fonseca,Fernando Luiz A. Sarni,Roseli Oselka S. |
dc.subject.por.fl_str_mv |
vitamin A obesity glucose metabolism disorders child adolescent |
topic |
vitamin A obesity glucose metabolism disorders child adolescent |
description |
Objective: To evaluate obese children and adolescents' retinol plasma levels and to correlate them with metabolic syndrome components.Methods: Cross-sectional study with 61 obese children and adolescents (body mass index Z score - ZBMI>+2). Pubertal development, arterial blood pressure, body weight and height for nutritional classification and waist circumference were obtained. A 15mL blood sample was collected (after a 12-hour fasting in a low luminosity room) for retinol determination (cut-off inadequate if <30µg/dL), lipid profile (HDL-c, LDL-c, and triglycerides), oral glucose tolerance test (fasting and 120 minutes) and for high sensitivity C-reactive protein. Spearman correlation and multiple linear regression were used in the statistical analysis.Results: Mean age was 10.7±2.7 years. There was a predominance of male gender 38/61 (62%) and pre-pubertal 35/61 (57%) subjects. The average plasmatic retinol was 48.5±18.6ug/dL. Retinol deficiency and severe obesity were observed in 6/61 (10%) and 36/61 (59%), respectively. Glucose level at 120 minutes was the independent and predictive variable of plasma retinol levels [β=-0.286 (95%CI -0.013 - -0.001)].Conclusions: An independent and inverse association between plasma retinol levels and glucose tolerance was observed, suggesting an important contribution of this vitamin in the morbidities associated to obesity in children and adolescents. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100050 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-05822014000100009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade de Pediatria de São Paulo |
publisher.none.fl_str_mv |
Sociedade de Pediatria de São Paulo |
dc.source.none.fl_str_mv |
Revista Paulista de Pediatria v.32 n.1 2014 reponame:Revista Paulista de Pediatria (Ed. Português. Online) instname:Sociedade de Pediatria de São Paulo (SPSP) instacron:SPSP |
instname_str |
Sociedade de Pediatria de São Paulo (SPSP) |
instacron_str |
SPSP |
institution |
SPSP |
reponame_str |
Revista Paulista de Pediatria (Ed. Português. Online) |
collection |
Revista Paulista de Pediatria (Ed. Português. Online) |
repository.name.fl_str_mv |
Revista Paulista de Pediatria (Ed. Português. Online) - Sociedade de Pediatria de São Paulo (SPSP) |
repository.mail.fl_str_mv |
pediatria@spsp.org.br||rpp@spsp.org.br |
_version_ |
1750318248811823104 |