Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)

Detalhes bibliográficos
Autor(a) principal: Benvenutti,Régis Carlos
Data de Publicação: 2019
Outros Autores: Gomes,Denise B., Zanchet,Barbara, Locateli,Gelvani, Vechia,Cristian Alex Dalla, Zanotelli Serpa,Patrícia, Lutinski,Junir, Rodrigues Junior,Sinval Adalberto, Schönell,Amanda Patrícia, Diel,Kriptsan Abdon Poletto, Miorando,Daniela, Ernetti,Jackeline, Alves,Bianca de Oliveira, Zilli,Gabriela Adriany Lisboa, Banzato,Thais Petrochelli, Ruiz,Ana Lúcia Tasca Gois, Vidal Gutiérrez,Max, Vilegas,Wagner, Roman Junior,Walter Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412
Resumo: Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI50 = 1.5 μg/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI50 = 12.7 and 9.4 μg/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.
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spelling Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)antitumor agentsmedicinal plantschemical analysisAbstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI50 = 1.5 μg/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI50 = 12.7 and 9.4 μg/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.Instituto de Tecnologia do Paraná - Tecpar2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412Brazilian Archives of Biology and Technology v.62 2019reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2019180531info:eu-repo/semantics/openAccessBenvenutti,Régis CarlosGomes,Denise B.Zanchet,BarbaraLocateli,GelvaniVechia,Cristian Alex DallaZanotelli Serpa,PatríciaLutinski,JunirRodrigues Junior,Sinval AdalbertoSchönell,Amanda PatríciaDiel,Kriptsan Abdon PolettoMiorando,DanielaErnetti,JackelineAlves,Bianca de OliveiraZilli,Gabriela Adriany LisboaBanzato,Thais PetrochelliRuiz,Ana Lúcia Tasca GoisVidal Gutiérrez,MaxVilegas,WagnerRoman Junior,Walter Antônioeng2019-10-21T00:00:00Zoai:scielo:S1516-89132019000100412Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2019-10-21T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
title Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
spellingShingle Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
Benvenutti,Régis Carlos
antitumor agents
medicinal plants
chemical analysis
title_short Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
title_full Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
title_fullStr Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
title_full_unstemmed Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
title_sort Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
author Benvenutti,Régis Carlos
author_facet Benvenutti,Régis Carlos
Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Vechia,Cristian Alex Dalla
Zanotelli Serpa,Patrícia
Lutinski,Junir
Rodrigues Junior,Sinval Adalberto
Schönell,Amanda Patrícia
Diel,Kriptsan Abdon Poletto
Miorando,Daniela
Ernetti,Jackeline
Alves,Bianca de Oliveira
Zilli,Gabriela Adriany Lisboa
Banzato,Thais Petrochelli
Ruiz,Ana Lúcia Tasca Gois
Vidal Gutiérrez,Max
Vilegas,Wagner
Roman Junior,Walter Antônio
author_role author
author2 Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Vechia,Cristian Alex Dalla
Zanotelli Serpa,Patrícia
Lutinski,Junir
Rodrigues Junior,Sinval Adalberto
Schönell,Amanda Patrícia
Diel,Kriptsan Abdon Poletto
Miorando,Daniela
Ernetti,Jackeline
Alves,Bianca de Oliveira
Zilli,Gabriela Adriany Lisboa
Banzato,Thais Petrochelli
Ruiz,Ana Lúcia Tasca Gois
Vidal Gutiérrez,Max
Vilegas,Wagner
Roman Junior,Walter Antônio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenutti,Régis Carlos
Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Vechia,Cristian Alex Dalla
Zanotelli Serpa,Patrícia
Lutinski,Junir
Rodrigues Junior,Sinval Adalberto
Schönell,Amanda Patrícia
Diel,Kriptsan Abdon Poletto
Miorando,Daniela
Ernetti,Jackeline
Alves,Bianca de Oliveira
Zilli,Gabriela Adriany Lisboa
Banzato,Thais Petrochelli
Ruiz,Ana Lúcia Tasca Gois
Vidal Gutiérrez,Max
Vilegas,Wagner
Roman Junior,Walter Antônio
dc.subject.por.fl_str_mv antitumor agents
medicinal plants
chemical analysis
topic antitumor agents
medicinal plants
chemical analysis
description Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI50 = 1.5 μg/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI50 = 12.7 and 9.4 μg/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4324-2019180531
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.62 2019
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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