Drug interaction with radiopharmaceuticals: a review

• Autor(a) principal: Bernardo-Filho,Mario
• Data de Publicação: 2005
• Outros Autores: Santos-Filho,Sebastião David, Moura,Egberto Gaspar de, Maiworm,Adalgisa Ieda, Orlando,Margarida Maria de Camões, Penas,Maria Expósito, Cardoso,Valbert Nascimento, Bernardo,Luciana Camargo, Brito,Lavínia de Carvalho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700003
• topic: Drug interaction; blood constituents; radiobiocomplexes; bioavailability

Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as radiation therapy, surgical procedures, prostheses, cardioversion, intubation, chemoperfusion, external massage, immunotherapy, blood transfusion and hemodialysis. In conclusion, the knowledge about these factors capable of interfering with the bioavailability of the radiobiocomplexes is worthwhile for secure diagnosis. Moreover, the development of biological models to study these phenomena is highly relevant and desirable.