Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin

Detalhes bibliográficos
Autor(a) principal: Almeida,Danielle Ayr Tavares de
Data de Publicação: 2012
Outros Autores: Braga,Camila Pereira, Novelli,Ethel Lourenzi Barbosa, Fernandes,Ana Angélica Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007
Resumo: The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.
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spelling Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitaminvitamin Elipid profileoxidative stressSTZThe present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.Instituto de Tecnologia do Paraná - Tecpar2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007Brazilian Archives of Biology and Technology v.55 n.4 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000400007info:eu-repo/semantics/openAccessAlmeida,Danielle Ayr Tavares deBraga,Camila PereiraNovelli,Ethel Lourenzi BarbosaFernandes,Ana Angélica Henriqueeng2016-12-08T00:00:00Zoai:scielo:S1516-89132012000400007Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2016-12-08T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
title Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
spellingShingle Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
Almeida,Danielle Ayr Tavares de
vitamin E
lipid profile
oxidative stress
STZ
title_short Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
title_full Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
title_fullStr Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
title_full_unstemmed Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
title_sort Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
author Almeida,Danielle Ayr Tavares de
author_facet Almeida,Danielle Ayr Tavares de
Braga,Camila Pereira
Novelli,Ethel Lourenzi Barbosa
Fernandes,Ana Angélica Henrique
author_role author
author2 Braga,Camila Pereira
Novelli,Ethel Lourenzi Barbosa
Fernandes,Ana Angélica Henrique
author2_role author
author
author
dc.contributor.author.fl_str_mv Almeida,Danielle Ayr Tavares de
Braga,Camila Pereira
Novelli,Ethel Lourenzi Barbosa
Fernandes,Ana Angélica Henrique
dc.subject.por.fl_str_mv vitamin E
lipid profile
oxidative stress
STZ
topic vitamin E
lipid profile
oxidative stress
STZ
description The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132012000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.55 n.4 2012
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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