Systems biology approach to study the high altitude adaptation in tibetans

Detalhes bibliográficos
Autor(a) principal: De,Bi
Data de Publicação: 2013
Outros Autores: Huajun,Xiao, Cuihong,Zhou, Jun,Zhou, Xiaoyan,Deng, Xiaopeng,Liu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
Resumo: The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
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spelling Systems biology approach to study the high altitude adaptation in tibetanssystems biologyTibetanhigh-altitude adaptationsingle nucleotide polymorphismmicroRNAThe aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.Instituto de Tecnologia do Paraná - Tecpar2013-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007Brazilian Archives of Biology and Technology v.56 n.1 2013reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132013000100007info:eu-repo/semantics/openAccessDe,BiHuajun,XiaoCuihong,ZhouJun,ZhouXiaoyan,DengXiaopeng,Liueng2013-04-09T00:00:00Zoai:scielo:S1516-89132013000100007Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2013-04-09T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Systems biology approach to study the high altitude adaptation in tibetans
title Systems biology approach to study the high altitude adaptation in tibetans
spellingShingle Systems biology approach to study the high altitude adaptation in tibetans
De,Bi
systems biology
Tibetan
high-altitude adaptation
single nucleotide polymorphism
microRNA
title_short Systems biology approach to study the high altitude adaptation in tibetans
title_full Systems biology approach to study the high altitude adaptation in tibetans
title_fullStr Systems biology approach to study the high altitude adaptation in tibetans
title_full_unstemmed Systems biology approach to study the high altitude adaptation in tibetans
title_sort Systems biology approach to study the high altitude adaptation in tibetans
author De,Bi
author_facet De,Bi
Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
author_role author
author2 Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv De,Bi
Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
dc.subject.por.fl_str_mv systems biology
Tibetan
high-altitude adaptation
single nucleotide polymorphism
microRNA
topic systems biology
Tibetan
high-altitude adaptation
single nucleotide polymorphism
microRNA
description The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132013000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.56 n.1 2013
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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