Dietary models for inducing hypercholesterolemia in rats
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006 |
Resumo: | The present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and 4,538.4 Kcal/Kg, since it promoted an increase in LDL-cholesterol, a decrease in the HDL fraction and affected less the hepatic function of the animals. |
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Dietary models for inducing hypercholesterolemia in ratsHypercholesterolemiaanimal modelcaloric valuecholesterolThe present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and 4,538.4 Kcal/Kg, since it promoted an increase in LDL-cholesterol, a decrease in the HDL fraction and affected less the hepatic function of the animals.Instituto de Tecnologia do Paraná - Tecpar2005-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006Brazilian Archives of Biology and Technology v.48 n.2 2005reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132005000200006info:eu-repo/semantics/openAccessMatos,Sheyla LeitePaula,Heberth dePedrosa,Maria LúciaSantos,Rinaldo Cardoso dosOliveira,Eduardo Luiz deChianca Júnior,Deoclécio AlvesSilva,Marcelo Eustáquioeng2005-04-26T00:00:00Zoai:scielo:S1516-89132005000200006Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2005-04-26T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Dietary models for inducing hypercholesterolemia in rats |
title |
Dietary models for inducing hypercholesterolemia in rats |
spellingShingle |
Dietary models for inducing hypercholesterolemia in rats Matos,Sheyla Leite Hypercholesterolemia animal model caloric value cholesterol |
title_short |
Dietary models for inducing hypercholesterolemia in rats |
title_full |
Dietary models for inducing hypercholesterolemia in rats |
title_fullStr |
Dietary models for inducing hypercholesterolemia in rats |
title_full_unstemmed |
Dietary models for inducing hypercholesterolemia in rats |
title_sort |
Dietary models for inducing hypercholesterolemia in rats |
author |
Matos,Sheyla Leite |
author_facet |
Matos,Sheyla Leite Paula,Heberth de Pedrosa,Maria Lúcia Santos,Rinaldo Cardoso dos Oliveira,Eduardo Luiz de Chianca Júnior,Deoclécio Alves Silva,Marcelo Eustáquio |
author_role |
author |
author2 |
Paula,Heberth de Pedrosa,Maria Lúcia Santos,Rinaldo Cardoso dos Oliveira,Eduardo Luiz de Chianca Júnior,Deoclécio Alves Silva,Marcelo Eustáquio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Matos,Sheyla Leite Paula,Heberth de Pedrosa,Maria Lúcia Santos,Rinaldo Cardoso dos Oliveira,Eduardo Luiz de Chianca Júnior,Deoclécio Alves Silva,Marcelo Eustáquio |
dc.subject.por.fl_str_mv |
Hypercholesterolemia animal model caloric value cholesterol |
topic |
Hypercholesterolemia animal model caloric value cholesterol |
description |
The present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and 4,538.4 Kcal/Kg, since it promoted an increase in LDL-cholesterol, a decrease in the HDL fraction and affected less the hepatic function of the animals. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132005000200006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.48 n.2 2005 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318270238425088 |