Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100327 |
Resumo: | ABSTRACT Essential oils are pharmacologically active and unexplored compounds. The inhibitory properties of essential oils from Baccharis dracunculifolia, Conyza bonariensis, Tithonia diversifolia and Ambrosia polystachya were evaluated in the coagulation and fibrinogenolysis induced by snake venoms. The essential oil from Conyza bonariensis extended the clotting time of Lachesis muta from 52.2 to 115.2 seconds and that of Bothrops moojeni from 108.3 to 2340.0 seconds, when pre-incubated with the venoms. The longest clotting times for Bothrops atrox venom were observed after incubation with the essential oils from Conyza bonariensis and Tithonia diversifolia: the times increased from 100.8 to 264.0 and 227.7 seconds, respectively. The prior incubation of the essential oils with plasma and subsequent addition of Lachesis muta venom resulted in a pro-clotting effect. The oils from Ambrosia polystachya and Baccharis dracunculifolia caused 100% of inhibition on the fibrinogenolysis induced by Bothrops moojeni and Lachesis muta venoms (the oils were previously incubated with the venom). The results indicate that the essential oils show promise as adjuvants for the treatment of snakebites. |
id |
TECPAR-1_491d2771f8dc3c39c392216159949bbf |
---|---|
oai_identifier_str |
oai:scielo:S1516-89132016000100327 |
network_acronym_str |
TECPAR-1 |
network_name_str |
Brazilian Archives of Biology and Technology |
repository_id_str |
|
spelling |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae familyProteases inhibitorsBaccharis dracunculifoliaConyza bonariensisTithonia diversifoliaAmbrosia polystachya.ABSTRACT Essential oils are pharmacologically active and unexplored compounds. The inhibitory properties of essential oils from Baccharis dracunculifolia, Conyza bonariensis, Tithonia diversifolia and Ambrosia polystachya were evaluated in the coagulation and fibrinogenolysis induced by snake venoms. The essential oil from Conyza bonariensis extended the clotting time of Lachesis muta from 52.2 to 115.2 seconds and that of Bothrops moojeni from 108.3 to 2340.0 seconds, when pre-incubated with the venoms. The longest clotting times for Bothrops atrox venom were observed after incubation with the essential oils from Conyza bonariensis and Tithonia diversifolia: the times increased from 100.8 to 264.0 and 227.7 seconds, respectively. The prior incubation of the essential oils with plasma and subsequent addition of Lachesis muta venom resulted in a pro-clotting effect. The oils from Ambrosia polystachya and Baccharis dracunculifolia caused 100% of inhibition on the fibrinogenolysis induced by Bothrops moojeni and Lachesis muta venoms (the oils were previously incubated with the venom). The results indicate that the essential oils show promise as adjuvants for the treatment of snakebites.Instituto de Tecnologia do Paraná - Tecpar2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100327Brazilian Archives of Biology and Technology v.59 2016reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2016150775info:eu-repo/semantics/openAccessMiranda,Cíntia Alvarenga Santos Fraga deCardoso,Maria das GraçasMarcussi,SilvanaTeixeira,Maria Luisaeng2017-01-20T00:00:00Zoai:scielo:S1516-89132016000100327Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2017-01-20T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
title |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
spellingShingle |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family Miranda,Cíntia Alvarenga Santos Fraga de Proteases inhibitors Baccharis dracunculifolia Conyza bonariensis Tithonia diversifolia Ambrosia polystachya. |
title_short |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
title_full |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
title_fullStr |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
title_full_unstemmed |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
title_sort |
Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family |
author |
Miranda,Cíntia Alvarenga Santos Fraga de |
author_facet |
Miranda,Cíntia Alvarenga Santos Fraga de Cardoso,Maria das Graças Marcussi,Silvana Teixeira,Maria Luisa |
author_role |
author |
author2 |
Cardoso,Maria das Graças Marcussi,Silvana Teixeira,Maria Luisa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Miranda,Cíntia Alvarenga Santos Fraga de Cardoso,Maria das Graças Marcussi,Silvana Teixeira,Maria Luisa |
dc.subject.por.fl_str_mv |
Proteases inhibitors Baccharis dracunculifolia Conyza bonariensis Tithonia diversifolia Ambrosia polystachya. |
topic |
Proteases inhibitors Baccharis dracunculifolia Conyza bonariensis Tithonia diversifolia Ambrosia polystachya. |
description |
ABSTRACT Essential oils are pharmacologically active and unexplored compounds. The inhibitory properties of essential oils from Baccharis dracunculifolia, Conyza bonariensis, Tithonia diversifolia and Ambrosia polystachya were evaluated in the coagulation and fibrinogenolysis induced by snake venoms. The essential oil from Conyza bonariensis extended the clotting time of Lachesis muta from 52.2 to 115.2 seconds and that of Bothrops moojeni from 108.3 to 2340.0 seconds, when pre-incubated with the venoms. The longest clotting times for Bothrops atrox venom were observed after incubation with the essential oils from Conyza bonariensis and Tithonia diversifolia: the times increased from 100.8 to 264.0 and 227.7 seconds, respectively. The prior incubation of the essential oils with plasma and subsequent addition of Lachesis muta venom resulted in a pro-clotting effect. The oils from Ambrosia polystachya and Baccharis dracunculifolia caused 100% of inhibition on the fibrinogenolysis induced by Bothrops moojeni and Lachesis muta venoms (the oils were previously incubated with the venom). The results indicate that the essential oils show promise as adjuvants for the treatment of snakebites. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100327 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4324-2016150775 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.59 2016 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318277341478912 |