Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100405 |
Resumo: | Abstract The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and western-blotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. Thus, the PJE was able to interfere in the hormonal signaling mediators, protecting the anterior prostate microenvironment and preventing lesion development due to aging associated or not with HFD intake. |
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Brazilian Archives of Biology and Technology |
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Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.JaboticabaHigh-fat dietProstateAndrogen receptorEstrogen receptorInsulin-like growth factor.Abstract The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and western-blotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. Thus, the PJE was able to interfere in the hormonal signaling mediators, protecting the anterior prostate microenvironment and preventing lesion development due to aging associated or not with HFD intake.Instituto de Tecnologia do Paraná - Tecpar2023-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100405Brazilian Archives of Biology and Technology v.66 2023reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2023220075info:eu-repo/semantics/openAccessLongo,Marjorie BarchaLamas,Celina de AlmeidaRossetto,Isabela UrraNogueira-Lima,EllenCollares-Busatto,Carla BeatrizMaróstica Junior,Mário RobertoQuitete,Valéria Helena Alves Cagnoneng2022-10-27T00:00:00Zoai:scielo:S1516-89132023000100405Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-10-27T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
title |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
spellingShingle |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. Longo,Marjorie Barcha Jaboticaba High-fat diet Prostate Androgen receptor Estrogen receptor Insulin-like growth factor. |
title_short |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
title_full |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
title_fullStr |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
title_full_unstemmed |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
title_sort |
Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders. |
author |
Longo,Marjorie Barcha |
author_facet |
Longo,Marjorie Barcha Lamas,Celina de Almeida Rossetto,Isabela Urra Nogueira-Lima,Ellen Collares-Busatto,Carla Beatriz Maróstica Junior,Mário Roberto Quitete,Valéria Helena Alves Cagnon |
author_role |
author |
author2 |
Lamas,Celina de Almeida Rossetto,Isabela Urra Nogueira-Lima,Ellen Collares-Busatto,Carla Beatriz Maróstica Junior,Mário Roberto Quitete,Valéria Helena Alves Cagnon |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Longo,Marjorie Barcha Lamas,Celina de Almeida Rossetto,Isabela Urra Nogueira-Lima,Ellen Collares-Busatto,Carla Beatriz Maróstica Junior,Mário Roberto Quitete,Valéria Helena Alves Cagnon |
dc.subject.por.fl_str_mv |
Jaboticaba High-fat diet Prostate Androgen receptor Estrogen receptor Insulin-like growth factor. |
topic |
Jaboticaba High-fat diet Prostate Androgen receptor Estrogen receptor Insulin-like growth factor. |
description |
Abstract The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and western-blotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. Thus, the PJE was able to interfere in the hormonal signaling mediators, protecting the anterior prostate microenvironment and preventing lesion development due to aging associated or not with HFD intake. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100405 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100405 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4324-2023220075 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.66 2023 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318281739206656 |