Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor

Detalhes bibliográficos
Autor(a) principal: Guimarães,Fernando
Data de Publicação: 2010
Outros Autores: Schanoski,Alessandra Soares, Cavalcanti,Tereza Cristina Samico, Juliano,Priscila Bianchi, Viera-Matos,Ana Neuza, Rettori,Ovídio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
Resumo: The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.
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spelling Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumorTumor growth ratespontaneous tumor regressionWistar ratsWalker 256The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.Instituto de Tecnologia do Paraná - Tecpar2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014Brazilian Archives of Biology and Technology v.53 n.5 2010reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132010000500014info:eu-repo/semantics/openAccessGuimarães,FernandoSchanoski,Alessandra SoaresCavalcanti,Tereza Cristina SamicoJuliano,Priscila BianchiViera-Matos,Ana NeuzaRettori,Ovídioeng2010-11-03T00:00:00Zoai:scielo:S1516-89132010000500014Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2010-11-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
spellingShingle Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
Guimarães,Fernando
Tumor growth rate
spontaneous tumor regression
Wistar rats
Walker 256
title_short Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_full Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_fullStr Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_full_unstemmed Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_sort Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
author Guimarães,Fernando
author_facet Guimarães,Fernando
Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
author_role author
author2 Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães,Fernando
Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
dc.subject.por.fl_str_mv Tumor growth rate
spontaneous tumor regression
Wistar rats
Walker 256
topic Tumor growth rate
spontaneous tumor regression
Wistar rats
Walker 256
description The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132010000500014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.53 n.5 2010
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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