Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro

Detalhes bibliográficos
Autor(a) principal: Sasson,Clarice Scliar
Data de Publicação: 2009
Outros Autores: Sato,Mayumi Eliza, Beletti,Klézia da Silva, Mota,Fabrício Cunha, Piaceski,Angela Dakiw
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006
Resumo: The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products.
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spelling Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro4-Methylbenzylidene-camphorsunscreenspenetrationvehiclesThe aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products.Instituto de Tecnologia do Paraná - Tecpar2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006Brazilian Archives of Biology and Technology v.52 n.2 2009reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132009000200006info:eu-repo/semantics/openAccessSasson,Clarice ScliarSato,Mayumi ElizaBeletti,Klézia da SilvaMota,Fabrício CunhaPiaceski,Angela Dakiweng2009-05-06T00:00:00Zoai:scielo:S1516-89132009000200006Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2009-05-06T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
title Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
spellingShingle Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
Sasson,Clarice Scliar
4-Methylbenzylidene-camphor
sunscreens
penetration
vehicles
title_short Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
title_full Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
title_fullStr Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
title_full_unstemmed Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
title_sort Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
author Sasson,Clarice Scliar
author_facet Sasson,Clarice Scliar
Sato,Mayumi Eliza
Beletti,Klézia da Silva
Mota,Fabrício Cunha
Piaceski,Angela Dakiw
author_role author
author2 Sato,Mayumi Eliza
Beletti,Klézia da Silva
Mota,Fabrício Cunha
Piaceski,Angela Dakiw
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sasson,Clarice Scliar
Sato,Mayumi Eliza
Beletti,Klézia da Silva
Mota,Fabrício Cunha
Piaceski,Angela Dakiw
dc.subject.por.fl_str_mv 4-Methylbenzylidene-camphor
sunscreens
penetration
vehicles
topic 4-Methylbenzylidene-camphor
sunscreens
penetration
vehicles
description The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products.
publishDate 2009
dc.date.none.fl_str_mv 2009-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132009000200006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.52 n.2 2009
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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