Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006 |
Resumo: | The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products. |
id |
TECPAR-1_7240c354c42ba467fa7f2c7cdd759328 |
---|---|
oai_identifier_str |
oai:scielo:S1516-89132009000200006 |
network_acronym_str |
TECPAR-1 |
network_name_str |
Brazilian Archives of Biology and Technology |
repository_id_str |
|
spelling |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro4-Methylbenzylidene-camphorsunscreenspenetrationvehiclesThe aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products.Instituto de Tecnologia do Paraná - Tecpar2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006Brazilian Archives of Biology and Technology v.52 n.2 2009reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132009000200006info:eu-repo/semantics/openAccessSasson,Clarice ScliarSato,Mayumi ElizaBeletti,Klézia da SilvaMota,Fabrício CunhaPiaceski,Angela Dakiweng2009-05-06T00:00:00Zoai:scielo:S1516-89132009000200006Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2009-05-06T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
title |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
spellingShingle |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro Sasson,Clarice Scliar 4-Methylbenzylidene-camphor sunscreens penetration vehicles |
title_short |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
title_full |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
title_fullStr |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
title_full_unstemmed |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
title_sort |
Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro |
author |
Sasson,Clarice Scliar |
author_facet |
Sasson,Clarice Scliar Sato,Mayumi Eliza Beletti,Klézia da Silva Mota,Fabrício Cunha Piaceski,Angela Dakiw |
author_role |
author |
author2 |
Sato,Mayumi Eliza Beletti,Klézia da Silva Mota,Fabrício Cunha Piaceski,Angela Dakiw |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sasson,Clarice Scliar Sato,Mayumi Eliza Beletti,Klézia da Silva Mota,Fabrício Cunha Piaceski,Angela Dakiw |
dc.subject.por.fl_str_mv |
4-Methylbenzylidene-camphor sunscreens penetration vehicles |
topic |
4-Methylbenzylidene-camphor sunscreens penetration vehicles |
description |
The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was present in the viable epidermis, dermis but most part of it, was found in the stratum corneum, being more remarkable for alcoholic gel. The right choice of the vehicle could decrease the potential toxicological risk and increase the efficacy of sunscreens products. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132009000200006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.52 n.2 2009 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318272770736128 |