Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100317 |
Resumo: | Abstract Aging and oxidative stress are important biological processes with extensive medical and social significance. The D-Galactose (D-Gal) has been used in animals for inducing oxidative stress and brain aging. The present study was conducted to evaluate the role of Lactobacillus brevis MG000874 in inhibiting the aging process and oxidative stress in D-Gal induced oxidative stress murine model. The cognitive responses and biochemical indicators were used to estimate the anti-aging and antioxidant potential of L. brevis MG000874 in mice. Tests used to assess cognitive responses, included object recognition, open field and T Maze. While antioxidant status was assessed by measuring superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-S-transferase (GST) activity in mice brain tissues. Results suggested that D-Gal can seriously impair the object recognition in mice. It led to significant reduction in ambulation, rearing, leaning and grooming. Similar trend was observed in antioxidant enzymes such as SOD, CAT and GSH except for GST where elevation was observed. Treatment with L. brevis MG000874 and ascorbic acid inhibited this reduction and kept levels close to control. Likewise, values of GSH of probiotic group were lower than negative control but significantly higher than positive control group. Probiotic supplementation in the presence of D-Gal displayed improvement in GSH, while no such improvement could be observed with ascorbic acid treatment. It can be concluded from the present study that L. brevis MG000874 can be used as anti-aging and antioxidant agent. It is recommended that L. brevis MG000874 could be included in the list of probiotics. |
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Brazilian Archives of Biology and Technology |
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Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine BrainL. brevis MG000874D-Galactoseanti-aging and antioxidant potentialprobioticsAbstract Aging and oxidative stress are important biological processes with extensive medical and social significance. The D-Galactose (D-Gal) has been used in animals for inducing oxidative stress and brain aging. The present study was conducted to evaluate the role of Lactobacillus brevis MG000874 in inhibiting the aging process and oxidative stress in D-Gal induced oxidative stress murine model. The cognitive responses and biochemical indicators were used to estimate the anti-aging and antioxidant potential of L. brevis MG000874 in mice. Tests used to assess cognitive responses, included object recognition, open field and T Maze. While antioxidant status was assessed by measuring superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-S-transferase (GST) activity in mice brain tissues. Results suggested that D-Gal can seriously impair the object recognition in mice. It led to significant reduction in ambulation, rearing, leaning and grooming. Similar trend was observed in antioxidant enzymes such as SOD, CAT and GSH except for GST where elevation was observed. Treatment with L. brevis MG000874 and ascorbic acid inhibited this reduction and kept levels close to control. Likewise, values of GSH of probiotic group were lower than negative control but significantly higher than positive control group. Probiotic supplementation in the presence of D-Gal displayed improvement in GSH, while no such improvement could be observed with ascorbic acid treatment. It can be concluded from the present study that L. brevis MG000874 can be used as anti-aging and antioxidant agent. It is recommended that L. brevis MG000874 could be included in the list of probiotics.Instituto de Tecnologia do Paraná - Tecpar2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100317Brazilian Archives of Biology and Technology v.65 2022reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2022210294info:eu-repo/semantics/openAccessNoureen,SalehaLiaqat,IramRiaz,AyeshaRana,MehwishArshad,Najmaeng2022-05-12T00:00:00Zoai:scielo:S1516-89132022000100317Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-05-12T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
title |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
spellingShingle |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain Noureen,Saleha L. brevis MG000874 D-Galactose anti-aging and antioxidant potential probiotics |
title_short |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
title_full |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
title_fullStr |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
title_full_unstemmed |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
title_sort |
Evaluation of Lactobacillus brevis MG000874 in Behavioral and In Vitro Antioxidant Enzyme Activity of Murine Brain |
author |
Noureen,Saleha |
author_facet |
Noureen,Saleha Liaqat,Iram Riaz,Ayesha Rana,Mehwish Arshad,Najma |
author_role |
author |
author2 |
Liaqat,Iram Riaz,Ayesha Rana,Mehwish Arshad,Najma |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Noureen,Saleha Liaqat,Iram Riaz,Ayesha Rana,Mehwish Arshad,Najma |
dc.subject.por.fl_str_mv |
L. brevis MG000874 D-Galactose anti-aging and antioxidant potential probiotics |
topic |
L. brevis MG000874 D-Galactose anti-aging and antioxidant potential probiotics |
description |
Abstract Aging and oxidative stress are important biological processes with extensive medical and social significance. The D-Galactose (D-Gal) has been used in animals for inducing oxidative stress and brain aging. The present study was conducted to evaluate the role of Lactobacillus brevis MG000874 in inhibiting the aging process and oxidative stress in D-Gal induced oxidative stress murine model. The cognitive responses and biochemical indicators were used to estimate the anti-aging and antioxidant potential of L. brevis MG000874 in mice. Tests used to assess cognitive responses, included object recognition, open field and T Maze. While antioxidant status was assessed by measuring superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-S-transferase (GST) activity in mice brain tissues. Results suggested that D-Gal can seriously impair the object recognition in mice. It led to significant reduction in ambulation, rearing, leaning and grooming. Similar trend was observed in antioxidant enzymes such as SOD, CAT and GSH except for GST where elevation was observed. Treatment with L. brevis MG000874 and ascorbic acid inhibited this reduction and kept levels close to control. Likewise, values of GSH of probiotic group were lower than negative control but significantly higher than positive control group. Probiotic supplementation in the presence of D-Gal displayed improvement in GSH, while no such improvement could be observed with ascorbic acid treatment. It can be concluded from the present study that L. brevis MG000874 can be used as anti-aging and antioxidant agent. It is recommended that L. brevis MG000874 could be included in the list of probiotics. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100317 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100317 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4324-2022210294 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.65 2022 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318281366962176 |