The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600010 |
Resumo: | The effect of a compound combining Valeriana officinalis and Passiflora alata extracts was tested on two mouse memory models: habituation and step-through inhibitory avoidance. Diazepam (1.0 and 2.5 mg/kg) was used as a positive control. Acute diazepam (2.5 mg/kg) before training impaired the habituation and performance in the inhibitory avoidance. On the other hand, acute phytotherapeutic compound (40-160 mg/kg), also before the training session, did not alter mouse behavior in these models. Repeated (15 days) treatment with the compound also did not impair the habituation. At the doses used, no locomotor effect was found. Taken together, the results suggest that, contrary to diazepam, the anxiolytic Valeriana officinalis and Passiflora alata compound did not induce amnesia. |
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The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepamamnesicbenzodiazepinememorymicephytotherapyThe effect of a compound combining Valeriana officinalis and Passiflora alata extracts was tested on two mouse memory models: habituation and step-through inhibitory avoidance. Diazepam (1.0 and 2.5 mg/kg) was used as a positive control. Acute diazepam (2.5 mg/kg) before training impaired the habituation and performance in the inhibitory avoidance. On the other hand, acute phytotherapeutic compound (40-160 mg/kg), also before the training session, did not alter mouse behavior in these models. Repeated (15 days) treatment with the compound also did not impair the habituation. At the doses used, no locomotor effect was found. Taken together, the results suggest that, contrary to diazepam, the anxiolytic Valeriana officinalis and Passiflora alata compound did not induce amnesia.Instituto de Tecnologia do Paraná - Tecpar2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600010Brazilian Archives of Biology and Technology v.53 n.6 2010reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132010000600010info:eu-repo/semantics/openAccessSlomp Junior,HelvoSeniski,GerusaCunha,Cláudio daAudi,Elizabeth AparecidaAndreatini,Robertoeng2011-01-18T00:00:00Zoai:scielo:S1516-89132010000600010Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-01-18T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
title |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
spellingShingle |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam Slomp Junior,Helvo amnesic benzodiazepine memory mice phytotherapy |
title_short |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
title_full |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
title_fullStr |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
title_full_unstemmed |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
title_sort |
The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam |
author |
Slomp Junior,Helvo |
author_facet |
Slomp Junior,Helvo Seniski,Gerusa Cunha,Cláudio da Audi,Elizabeth Aparecida Andreatini,Roberto |
author_role |
author |
author2 |
Seniski,Gerusa Cunha,Cláudio da Audi,Elizabeth Aparecida Andreatini,Roberto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Slomp Junior,Helvo Seniski,Gerusa Cunha,Cláudio da Audi,Elizabeth Aparecida Andreatini,Roberto |
dc.subject.por.fl_str_mv |
amnesic benzodiazepine memory mice phytotherapy |
topic |
amnesic benzodiazepine memory mice phytotherapy |
description |
The effect of a compound combining Valeriana officinalis and Passiflora alata extracts was tested on two mouse memory models: habituation and step-through inhibitory avoidance. Diazepam (1.0 and 2.5 mg/kg) was used as a positive control. Acute diazepam (2.5 mg/kg) before training impaired the habituation and performance in the inhibitory avoidance. On the other hand, acute phytotherapeutic compound (40-160 mg/kg), also before the training session, did not alter mouse behavior in these models. Repeated (15 days) treatment with the compound also did not impair the habituation. At the doses used, no locomotor effect was found. Taken together, the results suggest that, contrary to diazepam, the anxiolytic Valeriana officinalis and Passiflora alata compound did not induce amnesia. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132010000600010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.53 n.6 2010 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318274348843008 |