Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Detalhes bibliográficos
Autor(a) principal: Singh,Brij Mohan Kumar
Data de Publicação: 2022
Outros Autores: Mathew,Mary
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100330
Resumo: Abstract Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.
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spelling Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesisrenal fibrosismyofibroblastepithelial-mesenchymal transitionchronic kidney diseaseanti-fibrotic therapy.Abstract Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.Instituto de Tecnologia do Paraná - Tecpar2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100330Brazilian Archives of Biology and Technology v.65 2022reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2022210260info:eu-repo/semantics/openAccessSingh,Brij Mohan KumarMathew,Maryeng2022-08-04T00:00:00Zoai:scielo:S1516-89132022000100330Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-08-04T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
title Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
spellingShingle Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
Singh,Brij Mohan Kumar
renal fibrosis
myofibroblast
epithelial-mesenchymal transition
chronic kidney disease
anti-fibrotic therapy.
title_short Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
title_full Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
title_fullStr Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
title_full_unstemmed Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
title_sort Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
author Singh,Brij Mohan Kumar
author_facet Singh,Brij Mohan Kumar
Mathew,Mary
author_role author
author2 Mathew,Mary
author2_role author
dc.contributor.author.fl_str_mv Singh,Brij Mohan Kumar
Mathew,Mary
dc.subject.por.fl_str_mv renal fibrosis
myofibroblast
epithelial-mesenchymal transition
chronic kidney disease
anti-fibrotic therapy.
topic renal fibrosis
myofibroblast
epithelial-mesenchymal transition
chronic kidney disease
anti-fibrotic therapy.
description Abstract Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100330
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100330
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4324-2022210260
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.65 2022
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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