Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Detalhes bibliográficos
Autor(a) principal: Graça,José Ronaldo Vasconcelos
Data de Publicação: 2011
Outros Autores: Bezerra,Mirna Marques, Lima,Vilma, Rodrigues,José Ariévilo Gurgel, Monteiro,Diego Levi Silveira, Quinderé,Ana Luíza Gomes, Amorim,Rodrigo César das Neves, Paula,Regina Célia Monteiro de, Benevides,Norma Maria Barros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
Resumo: The aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P<0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.
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spelling Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractilityHalymenia floresiasulfated polysaccharidesgut motilityThe aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P<0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.Instituto de Tecnologia do Paraná - Tecpar2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008Brazilian Archives of Biology and Technology v.54 n.5 2011reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132011000500008info:eu-repo/semantics/openAccessGraça,José Ronaldo VasconcelosBezerra,Mirna MarquesLima,VilmaRodrigues,José Ariévilo GurgelMonteiro,Diego Levi SilveiraQuinderé,Ana Luíza GomesAmorim,Rodrigo César das NevesPaula,Regina Célia Monteiro deBenevides,Norma Maria Barroseng2011-11-01T00:00:00Zoai:scielo:S1516-89132011000500008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-11-01T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
title Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
spellingShingle Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
Graça,José Ronaldo Vasconcelos
Halymenia floresia
sulfated polysaccharides
gut motility
title_short Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
title_full Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
title_fullStr Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
title_full_unstemmed Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
title_sort Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
author Graça,José Ronaldo Vasconcelos
author_facet Graça,José Ronaldo Vasconcelos
Bezerra,Mirna Marques
Lima,Vilma
Rodrigues,José Ariévilo Gurgel
Monteiro,Diego Levi Silveira
Quinderé,Ana Luíza Gomes
Amorim,Rodrigo César das Neves
Paula,Regina Célia Monteiro de
Benevides,Norma Maria Barros
author_role author
author2 Bezerra,Mirna Marques
Lima,Vilma
Rodrigues,José Ariévilo Gurgel
Monteiro,Diego Levi Silveira
Quinderé,Ana Luíza Gomes
Amorim,Rodrigo César das Neves
Paula,Regina Célia Monteiro de
Benevides,Norma Maria Barros
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Graça,José Ronaldo Vasconcelos
Bezerra,Mirna Marques
Lima,Vilma
Rodrigues,José Ariévilo Gurgel
Monteiro,Diego Levi Silveira
Quinderé,Ana Luíza Gomes
Amorim,Rodrigo César das Neves
Paula,Regina Célia Monteiro de
Benevides,Norma Maria Barros
dc.subject.por.fl_str_mv Halymenia floresia
sulfated polysaccharides
gut motility
topic Halymenia floresia
sulfated polysaccharides
gut motility
description The aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P<0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132011000500008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.54 n.5 2011
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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