Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008 |
Resumo: | The aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia. |
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Brazilian Archives of Biology and Technology |
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Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant ratsdiabetesratpregnancyanomaliesfatty acid supplementationGamaline-VThe aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia.Instituto de Tecnologia do Paraná - Tecpar2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008Brazilian Archives of Biology and Technology v.55 n.5 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000500008info:eu-repo/semantics/openAccessConsonni,MarcosDamasceno,Débora CristinaKempinas,Wilma De GravaNassr,Azize Cristina CapelliVolpato,Gustavo TadeuDallaqua,BrunaIessi,Isabela LovizuttoSaito,Felipe HiroshiCalderon,Iracema Mattos ParanhosRudge,Marilza Vieira Cunhaeng2012-10-09T00:00:00Zoai:scielo:S1516-89132012000500008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-10-09T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
title |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
spellingShingle |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats Consonni,Marcos diabetes rat pregnancy anomalies fatty acid supplementation Gamaline-V |
title_short |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
title_full |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
title_fullStr |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
title_full_unstemmed |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
title_sort |
Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats |
author |
Consonni,Marcos |
author_facet |
Consonni,Marcos Damasceno,Débora Cristina Kempinas,Wilma De Grava Nassr,Azize Cristina Capelli Volpato,Gustavo Tadeu Dallaqua,Bruna Iessi,Isabela Lovizutto Saito,Felipe Hiroshi Calderon,Iracema Mattos Paranhos Rudge,Marilza Vieira Cunha |
author_role |
author |
author2 |
Damasceno,Débora Cristina Kempinas,Wilma De Grava Nassr,Azize Cristina Capelli Volpato,Gustavo Tadeu Dallaqua,Bruna Iessi,Isabela Lovizutto Saito,Felipe Hiroshi Calderon,Iracema Mattos Paranhos Rudge,Marilza Vieira Cunha |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Consonni,Marcos Damasceno,Débora Cristina Kempinas,Wilma De Grava Nassr,Azize Cristina Capelli Volpato,Gustavo Tadeu Dallaqua,Bruna Iessi,Isabela Lovizutto Saito,Felipe Hiroshi Calderon,Iracema Mattos Paranhos Rudge,Marilza Vieira Cunha |
dc.subject.por.fl_str_mv |
diabetes rat pregnancy anomalies fatty acid supplementation Gamaline-V |
topic |
diabetes rat pregnancy anomalies fatty acid supplementation Gamaline-V |
description |
The aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132012000500008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.55 n.5 2012 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318275268444160 |