Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats

Detalhes bibliográficos
Autor(a) principal: Consonni,Marcos
Data de Publicação: 2012
Outros Autores: Damasceno,Débora Cristina, Kempinas,Wilma De Grava, Nassr,Azize Cristina Capelli, Volpato,Gustavo Tadeu, Dallaqua,Bruna, Iessi,Isabela Lovizutto, Saito,Felipe Hiroshi, Calderon,Iracema Mattos Paranhos, Rudge,Marilza Vieira Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008
Resumo: The aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia.
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spelling Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant ratsdiabetesratpregnancyanomaliesfatty acid supplementationGamaline-VThe aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia.Instituto de Tecnologia do Paraná - Tecpar2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008Brazilian Archives of Biology and Technology v.55 n.5 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000500008info:eu-repo/semantics/openAccessConsonni,MarcosDamasceno,Débora CristinaKempinas,Wilma De GravaNassr,Azize Cristina CapelliVolpato,Gustavo TadeuDallaqua,BrunaIessi,Isabela LovizuttoSaito,Felipe HiroshiCalderon,Iracema Mattos ParanhosRudge,Marilza Vieira Cunhaeng2012-10-09T00:00:00Zoai:scielo:S1516-89132012000500008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-10-09T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
title Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
spellingShingle Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
Consonni,Marcos
diabetes
rat
pregnancy
anomalies
fatty acid supplementation
Gamaline-V
title_short Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
title_full Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
title_fullStr Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
title_full_unstemmed Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
title_sort Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats
author Consonni,Marcos
author_facet Consonni,Marcos
Damasceno,Débora Cristina
Kempinas,Wilma De Grava
Nassr,Azize Cristina Capelli
Volpato,Gustavo Tadeu
Dallaqua,Bruna
Iessi,Isabela Lovizutto
Saito,Felipe Hiroshi
Calderon,Iracema Mattos Paranhos
Rudge,Marilza Vieira Cunha
author_role author
author2 Damasceno,Débora Cristina
Kempinas,Wilma De Grava
Nassr,Azize Cristina Capelli
Volpato,Gustavo Tadeu
Dallaqua,Bruna
Iessi,Isabela Lovizutto
Saito,Felipe Hiroshi
Calderon,Iracema Mattos Paranhos
Rudge,Marilza Vieira Cunha
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Consonni,Marcos
Damasceno,Débora Cristina
Kempinas,Wilma De Grava
Nassr,Azize Cristina Capelli
Volpato,Gustavo Tadeu
Dallaqua,Bruna
Iessi,Isabela Lovizutto
Saito,Felipe Hiroshi
Calderon,Iracema Mattos Paranhos
Rudge,Marilza Vieira Cunha
dc.subject.por.fl_str_mv diabetes
rat
pregnancy
anomalies
fatty acid supplementation
Gamaline-V
topic diabetes
rat
pregnancy
anomalies
fatty acid supplementation
Gamaline-V
description The aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132012000500008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.55 n.5 2012
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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