Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200009 |
Resumo: | The aim of this study was to evaluate the glycogen content (GC) of the rat hind limb muscles submitted to joint immobilization, either associated with metformin treatment (M, 1,4mg.ml-1) or not. In the metformin group, there was a significant increase in the GC (soleus - S 65% , white gastrocnemius - WG 30.5%, red gastrocnemius- RG31.7%, extensor digitorum longus - EDL 44%, tibialis anterior- TA 77.4%). The immobilization significantly reduced the GC (S 31.6%, WG 56.6%, RG 39.1%, ELD 41.7%, TA 45.2%) and weight (S 34.2% and ELD 27%), whereas in the group immobilized with the metformin, there was an increase in the GC of all the muscles (S 177%, WG 290%, RG 172%,ELD 47%, TA 217%), in addition to minimizing the weight loss of S (29.6%) and ELD (27.8%). |
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Brazilian Archives of Biology and Technology |
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Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitationMuscle disusemetforminskeletal musclerehabilitationThe aim of this study was to evaluate the glycogen content (GC) of the rat hind limb muscles submitted to joint immobilization, either associated with metformin treatment (M, 1,4mg.ml-1) or not. In the metformin group, there was a significant increase in the GC (soleus - S 65% , white gastrocnemius - WG 30.5%, red gastrocnemius- RG31.7%, extensor digitorum longus - EDL 44%, tibialis anterior- TA 77.4%). The immobilization significantly reduced the GC (S 31.6%, WG 56.6%, RG 39.1%, ELD 41.7%, TA 45.2%) and weight (S 34.2% and ELD 27%), whereas in the group immobilized with the metformin, there was an increase in the GC of all the muscles (S 177%, WG 290%, RG 172%,ELD 47%, TA 217%), in addition to minimizing the weight loss of S (29.6%) and ELD (27.8%).Instituto de Tecnologia do Paraná - Tecpar2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200009Brazilian Archives of Biology and Technology v.51 n.2 2008reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132008000200009info:eu-repo/semantics/openAccessBosi,Paula LimaBorges,Gabriel DelfinoDurigan,João Luiz QuagliottiCancelliero,Karina MariaSilva,Carlos Alberto daeng2008-05-28T00:00:00Zoai:scielo:S1516-89132008000200009Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2008-05-28T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
title |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
spellingShingle |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation Bosi,Paula Lima Muscle disuse metformin skeletal muscle rehabilitation |
title_short |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
title_full |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
title_fullStr |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
title_full_unstemmed |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
title_sort |
Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation |
author |
Bosi,Paula Lima |
author_facet |
Bosi,Paula Lima Borges,Gabriel Delfino Durigan,João Luiz Quagliotti Cancelliero,Karina Maria Silva,Carlos Alberto da |
author_role |
author |
author2 |
Borges,Gabriel Delfino Durigan,João Luiz Quagliotti Cancelliero,Karina Maria Silva,Carlos Alberto da |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bosi,Paula Lima Borges,Gabriel Delfino Durigan,João Luiz Quagliotti Cancelliero,Karina Maria Silva,Carlos Alberto da |
dc.subject.por.fl_str_mv |
Muscle disuse metformin skeletal muscle rehabilitation |
topic |
Muscle disuse metformin skeletal muscle rehabilitation |
description |
The aim of this study was to evaluate the glycogen content (GC) of the rat hind limb muscles submitted to joint immobilization, either associated with metformin treatment (M, 1,4mg.ml-1) or not. In the metformin group, there was a significant increase in the GC (soleus - S 65% , white gastrocnemius - WG 30.5%, red gastrocnemius- RG31.7%, extensor digitorum longus - EDL 44%, tibialis anterior- TA 77.4%). The immobilization significantly reduced the GC (S 31.6%, WG 56.6%, RG 39.1%, ELD 41.7%, TA 45.2%) and weight (S 34.2% and ELD 27%), whereas in the group immobilized with the metformin, there was an increase in the GC of all the muscles (S 177%, WG 290%, RG 172%,ELD 47%, TA 217%), in addition to minimizing the weight loss of S (29.6%) and ELD (27.8%). |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132008000200009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.51 n.2 2008 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318271949701120 |