Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon

Detalhes bibliográficos
Autor(a) principal: Zanoni,Jacqueline Nelisis
Data de Publicação: 2007
Outros Autores: Pereira,Renata Virginia Fernandes, Freitas,Priscila de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100004
Resumo: The aim of this work was to study the effect of the ascorbic acid on the myenteric neurons of diabetic rats proximal colon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabetic with ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments were submitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The group DA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05). Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreated diabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHd myenteric neurons of the proximal colon of diabetic rats.
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spelling Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colonAscorbic acidcolondiabetesmyenteric neuronsThe aim of this work was to study the effect of the ascorbic acid on the myenteric neurons of diabetic rats proximal colon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabetic with ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments were submitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The group DA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05). Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreated diabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHd myenteric neurons of the proximal colon of diabetic rats.Instituto de Tecnologia do Paraná - Tecpar2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100004Brazilian Archives of Biology and Technology v.50 n.1 2007reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132007000100004info:eu-repo/semantics/openAccessZanoni,Jacqueline NelisisPereira,Renata Virginia FernandesFreitas,Priscila deeng2007-05-30T00:00:00Zoai:scielo:S1516-89132007000100004Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2007-05-30T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
title Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
spellingShingle Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
Zanoni,Jacqueline Nelisis
Ascorbic acid
colon
diabetes
myenteric neurons
title_short Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
title_full Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
title_fullStr Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
title_full_unstemmed Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
title_sort Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon
author Zanoni,Jacqueline Nelisis
author_facet Zanoni,Jacqueline Nelisis
Pereira,Renata Virginia Fernandes
Freitas,Priscila de
author_role author
author2 Pereira,Renata Virginia Fernandes
Freitas,Priscila de
author2_role author
author
dc.contributor.author.fl_str_mv Zanoni,Jacqueline Nelisis
Pereira,Renata Virginia Fernandes
Freitas,Priscila de
dc.subject.por.fl_str_mv Ascorbic acid
colon
diabetes
myenteric neurons
topic Ascorbic acid
colon
diabetes
myenteric neurons
description The aim of this work was to study the effect of the ascorbic acid on the myenteric neurons of diabetic rats proximal colon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabetic with ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments were submitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The group DA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05). Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreated diabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHd myenteric neurons of the proximal colon of diabetic rats.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132007000100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.50 n.1 2007
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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