Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties

Detalhes bibliográficos
Autor(a) principal: Duatti,Adriano
Data de Publicação: 2002
Outros Autores: Boschi,Alessandra, Uccelli,Licia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500019
Resumo: The chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal Tc<FONT FACE=Symbol>º</FONT>N triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and preliminary biological evaluation of the first class of monocationic nitrido technetium-99m radiopharmaceuticals exhibiting improved biodistribution properties closer to those expected for an ideal perfusion imaging agent.
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spelling Technetium-99m nitrido radiopharmaceuticals with unprecedented biological propertiesTechnetium-99m RadiopharmaceuticalsNitrido ComplexesThe chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal Tc<FONT FACE=Symbol>º</FONT>N triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and preliminary biological evaluation of the first class of monocationic nitrido technetium-99m radiopharmaceuticals exhibiting improved biodistribution properties closer to those expected for an ideal perfusion imaging agent.Instituto de Tecnologia do Paraná - Tecpar2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500019Brazilian Archives of Biology and Technology v.45 n.spe 2002reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132002000500019info:eu-repo/semantics/openAccessDuatti,AdrianoBoschi,AlessandraUccelli,Liciaeng2002-10-22T00:00:00Zoai:scielo:S1516-89132002000500019Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2002-10-22T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
title Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
spellingShingle Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
Duatti,Adriano
Technetium-99m Radiopharmaceuticals
Nitrido Complexes
title_short Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
title_full Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
title_fullStr Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
title_full_unstemmed Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
title_sort Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
author Duatti,Adriano
author_facet Duatti,Adriano
Boschi,Alessandra
Uccelli,Licia
author_role author
author2 Boschi,Alessandra
Uccelli,Licia
author2_role author
author
dc.contributor.author.fl_str_mv Duatti,Adriano
Boschi,Alessandra
Uccelli,Licia
dc.subject.por.fl_str_mv Technetium-99m Radiopharmaceuticals
Nitrido Complexes
topic Technetium-99m Radiopharmaceuticals
Nitrido Complexes
description The chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal Tc<FONT FACE=Symbol>º</FONT>N triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and preliminary biological evaluation of the first class of monocationic nitrido technetium-99m radiopharmaceuticals exhibiting improved biodistribution properties closer to those expected for an ideal perfusion imaging agent.
publishDate 2002
dc.date.none.fl_str_mv 2002-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132002000500019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.45 n.spe 2002
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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