Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects

Detalhes bibliográficos
Autor(a) principal: Rastogi,Meenal
Data de Publicação: 2016
Outros Autores: Gupta,Sameer, Sachan,Manisha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100346
Resumo: ABSTRACT Ovarian carcinoma accounts for highest mortality of all gynecologic malignancies as the disease is asymptomatic until late stages. Biomarkers such as CA-125 and HE4 are being currently used for diagnosis of ovarian cancer, but they show contradicting diagnostic accuracy. Therefore other biomarkers have been investigated for early detection of this disease, but no success has been obtained and no test has yet been recommended for screening a general population. In this instance, aptamers can be effectively used to identify tumor-specific antigens for early diagnosis and targeted therapy of ovarian cancer. This article provides an overview of the biomarkers/panels being explored as well as the potential of aptamers to improve current long-term survival rates of ovarian cancer.
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spelling Biomarkers towards Ovarian Cancer Diagnostics: Present and Future ProspectsOvarian canceraptamersDNA methylationCA-125HE4ABSTRACT Ovarian carcinoma accounts for highest mortality of all gynecologic malignancies as the disease is asymptomatic until late stages. Biomarkers such as CA-125 and HE4 are being currently used for diagnosis of ovarian cancer, but they show contradicting diagnostic accuracy. Therefore other biomarkers have been investigated for early detection of this disease, but no success has been obtained and no test has yet been recommended for screening a general population. In this instance, aptamers can be effectively used to identify tumor-specific antigens for early diagnosis and targeted therapy of ovarian cancer. This article provides an overview of the biomarkers/panels being explored as well as the potential of aptamers to improve current long-term survival rates of ovarian cancer.Instituto de Tecnologia do Paraná - Tecpar2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100346Brazilian Archives of Biology and Technology v.59 2016reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2016160070info:eu-repo/semantics/openAccessRastogi,MeenalGupta,SameerSachan,Manishaeng2016-10-26T00:00:00Zoai:scielo:S1516-89132016000100346Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2016-10-26T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
title Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
spellingShingle Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
Rastogi,Meenal
Ovarian cancer
aptamers
DNA methylation
CA-125
HE4
title_short Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
title_full Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
title_fullStr Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
title_full_unstemmed Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
title_sort Biomarkers towards Ovarian Cancer Diagnostics: Present and Future Prospects
author Rastogi,Meenal
author_facet Rastogi,Meenal
Gupta,Sameer
Sachan,Manisha
author_role author
author2 Gupta,Sameer
Sachan,Manisha
author2_role author
author
dc.contributor.author.fl_str_mv Rastogi,Meenal
Gupta,Sameer
Sachan,Manisha
dc.subject.por.fl_str_mv Ovarian cancer
aptamers
DNA methylation
CA-125
HE4
topic Ovarian cancer
aptamers
DNA methylation
CA-125
HE4
description ABSTRACT Ovarian carcinoma accounts for highest mortality of all gynecologic malignancies as the disease is asymptomatic until late stages. Biomarkers such as CA-125 and HE4 are being currently used for diagnosis of ovarian cancer, but they show contradicting diagnostic accuracy. Therefore other biomarkers have been investigated for early detection of this disease, but no success has been obtained and no test has yet been recommended for screening a general population. In this instance, aptamers can be effectively used to identify tumor-specific antigens for early diagnosis and targeted therapy of ovarian cancer. This article provides an overview of the biomarkers/panels being explored as well as the potential of aptamers to improve current long-term survival rates of ovarian cancer.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100346
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100346
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4324-2016160070
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.59 2016
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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