Effects of Chrysobalanus icaco on the labeling of blood constituents with technetium-99m and on the shape of the red blood cells

• Autor(a) principal: Presta,Giuseppe Antonio
• Data de Publicação: 2007
• Outros Autores: Santos-Filho,Sebastião David, Paoli,Severo de, Giani,Tania Santos, Maiworm,Adalgisa Ieda, Brandão-Neto,José, Medeiros,Aldo da Cunha, Fonseca,Adenilson de Souza da, Bernardo-Filho,Mario
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600018
• topic: Red blood cells; Technetium-99m; Morphometry; Chrysobalanus icaco

Chrysobalanus icaco (abajeru; C.icaco) is recommended in the treatment of diabetes and other clinical disorders. Blood constituents labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this study was to verify the effects of an abajeru extract on the labeling of blood constituents with 99mTc and on the shape of red blood cells (RBC). Blood samples(Wistar rats) were incubated with abajeru extract and the labeling of blood constituents with 99mTc and morphology of RBC were carried out. The results showed significant (P<0.05) alteration of labeling of blood constituents with 99mTc and the morphometry (perimeter/area ratio) of the RBC in presence of the extract. These data suggest that this abajeru extract could alter the labeling of blood constituents with 99mTc by its chelating/antioxidant action and/or effects on membrane structures involved in the ion transport.