Production of recombinant proteins in milk of transgenic and non-transgenic goats

Detalhes bibliográficos
Autor(a) principal: Moura,Raylene Ramos
Data de Publicação: 2011
Outros Autores: Melo,Luciana Magalhães, Freitas,Vicente José de Figueirêdo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500010
Resumo: Among all the transgenic mammalians produced so far, goats have represented an excellent model of transgenesis when considering the factors such as the market demand for protein, volume of milk produced per lactation and reproductive rate. Various recombinant proteins have been obtained from the transgenic and non-transgenic goats, and among these, human antithrombin, produced by the transgenic goats, was the first recombinant protein of animal origin to be released as a drug for the clinical use in humans. This review reports the aspects inherent to the production of recombinant proteins in the goats, from the production of the animal bioreactors up to the expression of these proteins in their milk.
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spelling Production of recombinant proteins in milk of transgenic and non-transgenic goatstransgenesisgoatrecombinant proteinmilkAmong all the transgenic mammalians produced so far, goats have represented an excellent model of transgenesis when considering the factors such as the market demand for protein, volume of milk produced per lactation and reproductive rate. Various recombinant proteins have been obtained from the transgenic and non-transgenic goats, and among these, human antithrombin, produced by the transgenic goats, was the first recombinant protein of animal origin to be released as a drug for the clinical use in humans. This review reports the aspects inherent to the production of recombinant proteins in the goats, from the production of the animal bioreactors up to the expression of these proteins in their milk.Instituto de Tecnologia do Paraná - Tecpar2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500010Brazilian Archives of Biology and Technology v.54 n.5 2011reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132011000500010info:eu-repo/semantics/openAccessMoura,Raylene RamosMelo,Luciana MagalhãesFreitas,Vicente José de Figueirêdoeng2011-11-01T00:00:00Zoai:scielo:S1516-89132011000500010Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-11-01T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Production of recombinant proteins in milk of transgenic and non-transgenic goats
title Production of recombinant proteins in milk of transgenic and non-transgenic goats
spellingShingle Production of recombinant proteins in milk of transgenic and non-transgenic goats
Moura,Raylene Ramos
transgenesis
goat
recombinant protein
milk
title_short Production of recombinant proteins in milk of transgenic and non-transgenic goats
title_full Production of recombinant proteins in milk of transgenic and non-transgenic goats
title_fullStr Production of recombinant proteins in milk of transgenic and non-transgenic goats
title_full_unstemmed Production of recombinant proteins in milk of transgenic and non-transgenic goats
title_sort Production of recombinant proteins in milk of transgenic and non-transgenic goats
author Moura,Raylene Ramos
author_facet Moura,Raylene Ramos
Melo,Luciana Magalhães
Freitas,Vicente José de Figueirêdo
author_role author
author2 Melo,Luciana Magalhães
Freitas,Vicente José de Figueirêdo
author2_role author
author
dc.contributor.author.fl_str_mv Moura,Raylene Ramos
Melo,Luciana Magalhães
Freitas,Vicente José de Figueirêdo
dc.subject.por.fl_str_mv transgenesis
goat
recombinant protein
milk
topic transgenesis
goat
recombinant protein
milk
description Among all the transgenic mammalians produced so far, goats have represented an excellent model of transgenesis when considering the factors such as the market demand for protein, volume of milk produced per lactation and reproductive rate. Various recombinant proteins have been obtained from the transgenic and non-transgenic goats, and among these, human antithrombin, produced by the transgenic goats, was the first recombinant protein of animal origin to be released as a drug for the clinical use in humans. This review reports the aspects inherent to the production of recombinant proteins in the goats, from the production of the animal bioreactors up to the expression of these proteins in their milk.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132011000500010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.54 n.5 2011
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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