Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UCB |
Texto Completo: | http://twingo.ucb.br:8080/jspui/handle/10869/603 https://repositorio.ucb.br:9443/jspui/handle/123456789/7870 |
Resumo: | Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperaturedependent cell morphology change from mycelium (22 ◦C) to yeast (36 ◦C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST sequencing in order to generate a partial map of the fungus transcriptome. Individual EST sequences were clustered by the CAP3 program and annotated using Blastx similarity analysis and InterPro Scan. Three different databases, GenBank nr, COG (clusters of orthologous groups) and GO (gene ontology) were used for annotation. A total of 3938 (Y = 1654 and M = 2274) ESTs were sequenced and clustered into 597 contigs and 1563 singlets, making up a total of 2160 genes, which possibly represent one-quarter of the complete gene repertoire in P. brasiliensis. From this total, 1040 were successfully annotated and 894 could be classified in 18 functional COG categories as follows: cellular metabolism (44%); information storage and processing (25%); cellular processes — cell division, posttranslational modifications, among others (19%); and genes of unknown functions (12%). Computer analysis enabled us to identify some genes potentially involved in the dimorphic transition and drug resistance. Furthermore, computer subtraction analysis revealed several genes possibly expressed in stage-specific forms of P. brasiliensis. Further analysis of these genes may provide new insights into the pathology and differentiation of P. brasiliensis. All EST sequences have been deposited in GenBank under Accession Nos CA580326–CA584263. |
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Felipe, Maria Sueli SoaresAndrade, Rosângela Vieira deSilva, Silvana Petrofeza daMaranhão, Andrea QueirozTorres, Fernando Araripe GonçalvesAndrade, Patrícia Albuquerque deArraes, Fabrício Barbosa MonteiroArruda, Maricilia Conceição Cardoso deAzevedo, M. O.Baptista, Alessandra JorgeBataus, Luiz Artur MendesBorges, Clayton LuizCampos, Elida GeraldaCruz, Marcio Rojas daDaher, Bruno SahiumDantas, Alessandra da SilvaFerreira, Marisa Alvares da Silva VellosoGhil, Guilherme VulpeJesuíno, Rosália Santos AmorimKyaw, Cynthia MariaLeitão, L.Martins, Cláudia Renata FernandesMoraes, Lidia Maria Pepe deNeves, Edvaldo OliveiraNicola, André MoraesAlves, E. S.Parente, Juliana AlvesPereira, MaristelaFonseca, Marcio José PoçasResende, Renato de OliveiraRibeiro, Bergmann MoraisSaldanha, Rosana Regina deSantos, S. C.Silva-Pereira, IldineteSilva, Marcos Antônio dos SantosSilveira, Erica DuarteSoares, Renata de Bastos AscençoSouza, Diorge Paulo deDe-Souza, Marlene TeixeiraAndrade, Edmar Vaz deXavier, Mauro Aparecido de SousaVeiga, Henrique PinheiroVenancio, Emerson JoséCarvalho, Maria José Albuquerque deOliveira, Adilton GuedesInoue, M. K.Almeida Junior, Nalvo Franco deWalter, Maria Emília Machado TellesSoares, Célia Maria de AlmeidaBrigido, Marcelo de Macedo2016-10-10T03:52:57Z2016-10-10T03:52:57Z2003FELIPE, Maria Sueli Soares et al. Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis. Yeast, v. 20, n. 3, p. 263-271, 2003.0749503Xhttp://twingo.ucb.br:8080/jspui/handle/10869/603https://repositorio.ucb.br:9443/jspui/handle/123456789/7870Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperaturedependent cell morphology change from mycelium (22 ◦C) to yeast (36 ◦C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST sequencing in order to generate a partial map of the fungus transcriptome. Individual EST sequences were clustered by the CAP3 program and annotated using Blastx similarity analysis and InterPro Scan. Three different databases, GenBank nr, COG (clusters of orthologous groups) and GO (gene ontology) were used for annotation. A total of 3938 (Y = 1654 and M = 2274) ESTs were sequenced and clustered into 597 contigs and 1563 singlets, making up a total of 2160 genes, which possibly represent one-quarter of the complete gene repertoire in P. brasiliensis. From this total, 1040 were successfully annotated and 894 could be classified in 18 functional COG categories as follows: cellular metabolism (44%); information storage and processing (25%); cellular processes — cell division, posttranslational modifications, among others (19%); and genes of unknown functions (12%). Computer analysis enabled us to identify some genes potentially involved in the dimorphic transition and drug resistance. Furthermore, computer subtraction analysis revealed several genes possibly expressed in stage-specific forms of P. brasiliensis. Further analysis of these genes may provide new insights into the pathology and differentiation of P. brasiliensis. All EST sequences have been deposited in GenBank under Accession Nos CA580326–CA584263.Made available in DSpace on 2016-10-10T03:52:57Z (GMT). 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de Publicaçõeshttps://repositorio.ucb.br:9443/jspui/ |
dc.title.pt_BR.fl_str_mv |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
title |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
spellingShingle |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis Felipe, Maria Sueli Soares ESTs Transcriptome Functional genomics Human pathogenic fungus Dimorphism Paracocidioides brasiliensis |
title_short |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
title_full |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
title_fullStr |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
title_full_unstemmed |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
title_sort |
Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis |
author |
Felipe, Maria Sueli Soares |
author_facet |
Felipe, Maria Sueli Soares Andrade, Rosângela Vieira de Silva, Silvana Petrofeza da Maranhão, Andrea Queiroz Torres, Fernando Araripe Gonçalves Andrade, Patrícia Albuquerque de Arraes, Fabrício Barbosa Monteiro Arruda, Maricilia Conceição Cardoso de Azevedo, M. O. Baptista, Alessandra Jorge Bataus, Luiz Artur Mendes Borges, Clayton Luiz Campos, Elida Geralda Cruz, Marcio Rojas da Daher, Bruno Sahium Dantas, Alessandra da Silva Ferreira, Marisa Alvares da Silva Velloso Ghil, Guilherme Vulpe Jesuíno, Rosália Santos Amorim Kyaw, Cynthia Maria Leitão, L. Martins, Cláudia Renata Fernandes Moraes, Lidia Maria Pepe de Neves, Edvaldo Oliveira Nicola, André Moraes Alves, E. S. Parente, Juliana Alves Pereira, Maristela Fonseca, Marcio José Poças Resende, Renato de Oliveira Ribeiro, Bergmann Morais Saldanha, Rosana Regina de Santos, S. C. Silva-Pereira, Ildinete Silva, Marcos Antônio dos Santos Silveira, Erica Duarte Soares, Renata de Bastos Ascenço Souza, Diorge Paulo de De-Souza, Marlene Teixeira Andrade, Edmar Vaz de Xavier, Mauro Aparecido de Sousa Veiga, Henrique Pinheiro Venancio, Emerson José Carvalho, Maria José Albuquerque de Oliveira, Adilton Guedes Inoue, M. K. Almeida Junior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Brigido, Marcelo de Macedo |
author_role |
author |
author2 |
Andrade, Rosângela Vieira de Silva, Silvana Petrofeza da Maranhão, Andrea Queiroz Torres, Fernando Araripe Gonçalves Andrade, Patrícia Albuquerque de Arraes, Fabrício Barbosa Monteiro Arruda, Maricilia Conceição Cardoso de Azevedo, M. O. Baptista, Alessandra Jorge Bataus, Luiz Artur Mendes Borges, Clayton Luiz Campos, Elida Geralda Cruz, Marcio Rojas da Daher, Bruno Sahium Dantas, Alessandra da Silva Ferreira, Marisa Alvares da Silva Velloso Ghil, Guilherme Vulpe Jesuíno, Rosália Santos Amorim Kyaw, Cynthia Maria Leitão, L. Martins, Cláudia Renata Fernandes Moraes, Lidia Maria Pepe de Neves, Edvaldo Oliveira Nicola, André Moraes Alves, E. S. Parente, Juliana Alves Pereira, Maristela Fonseca, Marcio José Poças Resende, Renato de Oliveira Ribeiro, Bergmann Morais Saldanha, Rosana Regina de Santos, S. C. Silva-Pereira, Ildinete Silva, Marcos Antônio dos Santos Silveira, Erica Duarte Soares, Renata de Bastos Ascenço Souza, Diorge Paulo de De-Souza, Marlene Teixeira Andrade, Edmar Vaz de Xavier, Mauro Aparecido de Sousa Veiga, Henrique Pinheiro Venancio, Emerson José Carvalho, Maria José Albuquerque de Oliveira, Adilton Guedes Inoue, M. K. Almeida Junior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Brigido, Marcelo de Macedo |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Felipe, Maria Sueli Soares Andrade, Rosângela Vieira de Silva, Silvana Petrofeza da Maranhão, Andrea Queiroz Torres, Fernando Araripe Gonçalves Andrade, Patrícia Albuquerque de Arraes, Fabrício Barbosa Monteiro Arruda, Maricilia Conceição Cardoso de Azevedo, M. O. Baptista, Alessandra Jorge Bataus, Luiz Artur Mendes Borges, Clayton Luiz Campos, Elida Geralda Cruz, Marcio Rojas da Daher, Bruno Sahium Dantas, Alessandra da Silva Ferreira, Marisa Alvares da Silva Velloso Ghil, Guilherme Vulpe Jesuíno, Rosália Santos Amorim Kyaw, Cynthia Maria Leitão, L. Martins, Cláudia Renata Fernandes Moraes, Lidia Maria Pepe de Neves, Edvaldo Oliveira Nicola, André Moraes Alves, E. S. Parente, Juliana Alves Pereira, Maristela Fonseca, Marcio José Poças Resende, Renato de Oliveira Ribeiro, Bergmann Morais Saldanha, Rosana Regina de Santos, S. C. Silva-Pereira, Ildinete Silva, Marcos Antônio dos Santos Silveira, Erica Duarte Soares, Renata de Bastos Ascenço Souza, Diorge Paulo de De-Souza, Marlene Teixeira Andrade, Edmar Vaz de Xavier, Mauro Aparecido de Sousa Veiga, Henrique Pinheiro Venancio, Emerson José Carvalho, Maria José Albuquerque de Oliveira, Adilton Guedes Inoue, M. K. Almeida Junior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Brigido, Marcelo de Macedo |
dc.subject.por.fl_str_mv |
ESTs Transcriptome Functional genomics Human pathogenic fungus Dimorphism Paracocidioides brasiliensis |
topic |
ESTs Transcriptome Functional genomics Human pathogenic fungus Dimorphism Paracocidioides brasiliensis |
dc.description.abstract.por.fl_txt_mv |
Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperaturedependent cell morphology change from mycelium (22 ◦C) to yeast (36 ◦C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST sequencing in order to generate a partial map of the fungus transcriptome. Individual EST sequences were clustered by the CAP3 program and annotated using Blastx similarity analysis and InterPro Scan. Three different databases, GenBank nr, COG (clusters of orthologous groups) and GO (gene ontology) were used for annotation. A total of 3938 (Y = 1654 and M = 2274) ESTs were sequenced and clustered into 597 contigs and 1563 singlets, making up a total of 2160 genes, which possibly represent one-quarter of the complete gene repertoire in P. brasiliensis. From this total, 1040 were successfully annotated and 894 could be classified in 18 functional COG categories as follows: cellular metabolism (44%); information storage and processing (25%); cellular processes — cell division, posttranslational modifications, among others (19%); and genes of unknown functions (12%). Computer analysis enabled us to identify some genes potentially involved in the dimorphic transition and drug resistance. Furthermore, computer subtraction analysis revealed several genes possibly expressed in stage-specific forms of P. brasiliensis. Further analysis of these genes may provide new insights into the pathology and differentiation of P. brasiliensis. All EST sequences have been deposited in GenBank under Accession Nos CA580326–CA584263. |
dc.description.version.pt_BR.fl_txt_mv |
Sim |
dc.description.status.pt_BR.fl_txt_mv |
Publicado |
description |
Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperaturedependent cell morphology change from mycelium (22 ◦C) to yeast (36 ◦C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST sequencing in order to generate a partial map of the fungus transcriptome. Individual EST sequences were clustered by the CAP3 program and annotated using Blastx similarity analysis and InterPro Scan. Three different databases, GenBank nr, COG (clusters of orthologous groups) and GO (gene ontology) were used for annotation. A total of 3938 (Y = 1654 and M = 2274) ESTs were sequenced and clustered into 597 contigs and 1563 singlets, making up a total of 2160 genes, which possibly represent one-quarter of the complete gene repertoire in P. brasiliensis. From this total, 1040 were successfully annotated and 894 could be classified in 18 functional COG categories as follows: cellular metabolism (44%); information storage and processing (25%); cellular processes — cell division, posttranslational modifications, among others (19%); and genes of unknown functions (12%). Computer analysis enabled us to identify some genes potentially involved in the dimorphic transition and drug resistance. Furthermore, computer subtraction analysis revealed several genes possibly expressed in stage-specific forms of P. brasiliensis. Further analysis of these genes may provide new insights into the pathology and differentiation of P. brasiliensis. All EST sequences have been deposited in GenBank under Accession Nos CA580326–CA584263. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2016-10-10T03:52:57Z |
dc.date.available.fl_str_mv |
2016-10-10T03:52:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
status_str |
publishedVersion |
format |
article |
dc.identifier.citation.fl_str_mv |
FELIPE, Maria Sueli Soares et al. Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis. Yeast, v. 20, n. 3, p. 263-271, 2003. |
dc.identifier.uri.fl_str_mv |
http://twingo.ucb.br:8080/jspui/handle/10869/603 https://repositorio.ucb.br:9443/jspui/handle/123456789/7870 |
dc.identifier.issn.none.fl_str_mv |
0749503X |
identifier_str_mv |
FELIPE, Maria Sueli Soares et al. Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis. Yeast, v. 20, n. 3, p. 263-271, 2003. 0749503X |
url |
http://twingo.ucb.br:8080/jspui/handle/10869/603 https://repositorio.ucb.br:9443/jspui/handle/123456789/7870 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.publisherversion.pt_BR.fl_str_mv |
http://vsites.unb.br/ib/cel/imol/papergenomaPb.pdf |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Católica de Brasília (UCB) |
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UCB |
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UCB |
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Repositório Institucional da UCB |
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Repositório Institucional da UCB |
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