Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UCB |
Texto Completo: | http://twingo.ucb.br:8080/jspui/handle/10869/590 https://repositorio.ucb.br:9443/jspui/handle/123456789/7661 |
Resumo: | Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy–Weinberg equilibrium. Prior to adjustment, individuals carrying the e2 allele showed higher serum levels of triglycerides (P\0.05) and VLDL (P\0.005) compared to e4 carriers, whereas LDL levels were considerably elevated in e4 compared to e2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, e4 carriers lost protection against hypertriglyceridemia. There was no association of the apolipoprotein A5 and B genotypes with lipidemic levels independently of the fat intake regimen. Results are suggestive of a dysbetalipoproteinemic- like phenotype in postmenopausal women, with remarkable gene–diet interaction. |
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Silva, Paula RobertaSouza, Vinícius Carolino deBenedet, Andréa LessaSouza, Elias Rodrigues deToledo, Juliana Oliveira deMoraes, Clayton FrancoGomes, LucyAlho, Clarice SampaioCordova, Claudio Olavo deNóbrega, Otávio de Toledo2016-10-10T03:52:16Z2016-10-10T03:52:16Z2010SILVA, Paula Roberta da et al. Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. Molecular and Cellular Biochemistry, v. 337, p. 307-315, 2010.03008177http://twingo.ucb.br:8080/jspui/handle/10869/590https://repositorio.ucb.br:9443/jspui/handle/123456789/7661Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy–Weinberg equilibrium. Prior to adjustment, individuals carrying the e2 allele showed higher serum levels of triglycerides (P\0.05) and VLDL (P\0.005) compared to e4 carriers, whereas LDL levels were considerably elevated in e4 compared to e2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, e4 carriers lost protection against hypertriglyceridemia. There was no association of the apolipoprotein A5 and B genotypes with lipidemic levels independently of the fat intake regimen. Results are suggestive of a dysbetalipoproteinemic- like phenotype in postmenopausal women, with remarkable gene–diet interaction.Made available in DSpace on 2016-10-10T03:52:16Z (GMT). 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dc.title.pt_BR.fl_str_mv |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
title |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
spellingShingle |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. Silva, Paula Roberta Hypertriglyceridemia Dysbetalipoproteinemia Genetic polymorphism Food intake Fatty acids Gender Older adult |
title_short |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
title_full |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
title_fullStr |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
title_full_unstemmed |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
title_sort |
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. |
author |
Silva, Paula Roberta |
author_facet |
Silva, Paula Roberta Souza, Vinícius Carolino de Benedet, Andréa Lessa Souza, Elias Rodrigues de Toledo, Juliana Oliveira de Moraes, Clayton Franco Gomes, Lucy Alho, Clarice Sampaio Cordova, Claudio Olavo de Nóbrega, Otávio de Toledo |
author_role |
author |
author2 |
Souza, Vinícius Carolino de Benedet, Andréa Lessa Souza, Elias Rodrigues de Toledo, Juliana Oliveira de Moraes, Clayton Franco Gomes, Lucy Alho, Clarice Sampaio Cordova, Claudio Olavo de Nóbrega, Otávio de Toledo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Paula Roberta Souza, Vinícius Carolino de Benedet, Andréa Lessa Souza, Elias Rodrigues de Toledo, Juliana Oliveira de Moraes, Clayton Franco Gomes, Lucy Alho, Clarice Sampaio Cordova, Claudio Olavo de Nóbrega, Otávio de Toledo |
dc.subject.por.fl_str_mv |
Hypertriglyceridemia Dysbetalipoproteinemia Genetic polymorphism Food intake Fatty acids Gender Older adult |
topic |
Hypertriglyceridemia Dysbetalipoproteinemia Genetic polymorphism Food intake Fatty acids Gender Older adult |
dc.description.abstract.por.fl_txt_mv |
Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy–Weinberg equilibrium. Prior to adjustment, individuals carrying the e2 allele showed higher serum levels of triglycerides (P\0.05) and VLDL (P\0.005) compared to e4 carriers, whereas LDL levels were considerably elevated in e4 compared to e2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, e4 carriers lost protection against hypertriglyceridemia. There was no association of the apolipoprotein A5 and B genotypes with lipidemic levels independently of the fat intake regimen. Results are suggestive of a dysbetalipoproteinemic- like phenotype in postmenopausal women, with remarkable gene–diet interaction. |
dc.description.version.pt_BR.fl_txt_mv |
Sim |
description |
Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy–Weinberg equilibrium. Prior to adjustment, individuals carrying the e2 allele showed higher serum levels of triglycerides (P\0.05) and VLDL (P\0.005) compared to e4 carriers, whereas LDL levels were considerably elevated in e4 compared to e2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, e4 carriers lost protection against hypertriglyceridemia. There was no association of the apolipoprotein A5 and B genotypes with lipidemic levels independently of the fat intake regimen. Results are suggestive of a dysbetalipoproteinemic- like phenotype in postmenopausal women, with remarkable gene–diet interaction. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2016-10-10T03:52:16Z |
dc.date.available.fl_str_mv |
2016-10-10T03:52:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
format |
article |
dc.identifier.citation.fl_str_mv |
SILVA, Paula Roberta da et al. Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. Molecular and Cellular Biochemistry, v. 337, p. 307-315, 2010. |
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http://twingo.ucb.br:8080/jspui/handle/10869/590 https://repositorio.ucb.br:9443/jspui/handle/123456789/7661 |
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03008177 |
identifier_str_mv |
SILVA, Paula Roberta da et al. Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. Molecular and Cellular Biochemistry, v. 337, p. 307-315, 2010. 03008177 |
url |
http://twingo.ucb.br:8080/jspui/handle/10869/590 https://repositorio.ucb.br:9443/jspui/handle/123456789/7661 |
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eng |
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eng |
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