Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection

Detalhes bibliográficos
Autor(a) principal: Franco, Octávio L.
Data de Publicação: 2002
Outros Autores: Rigden, Daniel J., Melo, Francislete R., Grossi-de-Sa, Maria F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UCB
Texto Completo: http://twingo.ucb.br:8080/jspui/handle/10869/538
https://repositorio.ucb.br:9443/jspui/handle/123456789/7654
Resumo: Insect pests and pathogens (fungi, bacteria and viruses) are responsible for severe crop losses. Insects feed directly on the plant tissues, while the pathogens lead to damage or death of the plant. Plants have evolved a certain degree of resistance through the production of defence compounds, which may be aproteic, e.g. antibiotics, alkaloids, terpenes, cyanogenic glucosides or proteic, e.g. chitinases, b-1,3-glu- canases, lectins, arcelins, vicilins, systemins and enzyme inhibitors. The enzyme inhibitors impede digestion through their action on insect gut digestive a-amylases and pro- teinases, which play a key role in the digestion of plant starch and proteins. The natural defences of crop plants may be improved through the use of transgenic technology. Current research in the area focuses particularly on weevils as these are highly dependent on starch for their energy supply. Six di€erent a-amylase inhibitor classes, lectin-like, knottin-like, cereal-type, Kunitz-like, c-purothionin-like and thaumatin-like could be used in pest control. These classes of inhibitors show remarkable structural variety leading to di€erent modes of inhibition and di€erent speci®city pro®les against diverse a-amylases. Speci®city of inhibition is an important issue as the introduced inhibitor must not adversely a€ect the plant's own a-amylases, nor the nutritional value of the crop. Of particular interest are some bifunctional inhibitors with additional favourable properties, such as proteinase inhibitory activity or chitin- ase activity. The area has bene®ted from the recent deter- mination of many structures of a-amylases, inhibitors and complexes. These structures highlight the remarkable variety in structural modes of a-amylase inhibition. The continuing discovery of new classes of a-amylase inhibitor ensures that exciting discoveries remain to be made. In this review, we summarize existing knowledge of insect a-am- ylases, plant a-amylase inhibitors and their interaction. Positive results recently obtained for transgenic plants and future prospects in the area are reviewed.
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spelling Franco, Octávio L.Rigden, Daniel J.Melo, Francislete R.Grossi-de-Sa, Maria F.2016-10-10T03:52:14Z2016-10-10T03:52:14Z2002FRANCO, Octávio L. Plant a-amylase inhibitors and their interaction with insect a-amylases Structure, function and potential for crop protection. Eur. J. Biochem. v. 269, p. 397- 412, 2002.http://twingo.ucb.br:8080/jspui/handle/10869/538https://repositorio.ucb.br:9443/jspui/handle/123456789/7654Insect pests and pathogens (fungi, bacteria and viruses) are responsible for severe crop losses. Insects feed directly on the plant tissues, while the pathogens lead to damage or death of the plant. Plants have evolved a certain degree of resistance through the production of defence compounds, which may be aproteic, e.g. antibiotics, alkaloids, terpenes, cyanogenic glucosides or proteic, e.g. chitinases, b-1,3-glu- canases, lectins, arcelins, vicilins, systemins and enzyme inhibitors. The enzyme inhibitors impede digestion through their action on insect gut digestive a-amylases and pro- teinases, which play a key role in the digestion of plant starch and proteins. The natural defences of crop plants may be improved through the use of transgenic technology. Current research in the area focuses particularly on weevils as these are highly dependent on starch for their energy supply. Six di€erent a-amylase inhibitor classes, lectin-like, knottin-like, cereal-type, Kunitz-like, c-purothionin-like and thaumatin-like could be used in pest control. These classes of inhibitors show remarkable structural variety leading to di€erent modes of inhibition and di€erent speci®city pro®les against diverse a-amylases. Speci®city of inhibition is an important issue as the introduced inhibitor must not adversely a€ect the plant's own a-amylases, nor the nutritional value of the crop. Of particular interest are some bifunctional inhibitors with additional favourable properties, such as proteinase inhibitory activity or chitin- ase activity. The area has bene®ted from the recent deter- mination of many structures of a-amylases, inhibitors and complexes. These structures highlight the remarkable variety in structural modes of a-amylase inhibition. The continuing discovery of new classes of a-amylase inhibitor ensures that exciting discoveries remain to be made. In this review, we summarize existing knowledge of insect a-am- ylases, plant a-amylase inhibitors and their interaction. Positive results recently obtained for transgenic plants and future prospects in the area are reviewed.Made available in DSpace on 2016-10-10T03:52:14Z (GMT). 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dc.title.pt_BR.fl_str_mv Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
title Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
spellingShingle Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
Franco, Octávio L.
A-Amylase Inhibitor
Knottin-like
Lectin-like
Thaumatin-like
Kunitz
Cereal-type
Bean weevil
Bifunctional inhibitors
title_short Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
title_full Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
title_fullStr Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
title_full_unstemmed Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
title_sort Plant a-amylase inhibitors and their interaction with insect a-amylases structure, function and potential for crop protection
author Franco, Octávio L.
author_facet Franco, Octávio L.
Rigden, Daniel J.
Melo, Francislete R.
Grossi-de-Sa, Maria F.
author_role author
author2 Rigden, Daniel J.
Melo, Francislete R.
Grossi-de-Sa, Maria F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Franco, Octávio L.
Rigden, Daniel J.
Melo, Francislete R.
Grossi-de-Sa, Maria F.
dc.subject.por.fl_str_mv A-Amylase Inhibitor
Knottin-like
Lectin-like
Thaumatin-like
Kunitz
Cereal-type
Bean weevil
Bifunctional inhibitors
topic A-Amylase Inhibitor
Knottin-like
Lectin-like
Thaumatin-like
Kunitz
Cereal-type
Bean weevil
Bifunctional inhibitors
dc.description.sponsorship.fl_txt_mv Federation of european biochemical societies
dc.description.abstract.por.fl_txt_mv Insect pests and pathogens (fungi, bacteria and viruses) are responsible for severe crop losses. Insects feed directly on the plant tissues, while the pathogens lead to damage or death of the plant. Plants have evolved a certain degree of resistance through the production of defence compounds, which may be aproteic, e.g. antibiotics, alkaloids, terpenes, cyanogenic glucosides or proteic, e.g. chitinases, b-1,3-glu- canases, lectins, arcelins, vicilins, systemins and enzyme inhibitors. The enzyme inhibitors impede digestion through their action on insect gut digestive a-amylases and pro- teinases, which play a key role in the digestion of plant starch and proteins. The natural defences of crop plants may be improved through the use of transgenic technology. Current research in the area focuses particularly on weevils as these are highly dependent on starch for their energy supply. Six di€erent a-amylase inhibitor classes, lectin-like, knottin-like, cereal-type, Kunitz-like, c-purothionin-like and thaumatin-like could be used in pest control. These classes of inhibitors show remarkable structural variety leading to di€erent modes of inhibition and di€erent speci®city pro®les against diverse a-amylases. Speci®city of inhibition is an important issue as the introduced inhibitor must not adversely a€ect the plant's own a-amylases, nor the nutritional value of the crop. Of particular interest are some bifunctional inhibitors with additional favourable properties, such as proteinase inhibitory activity or chitin- ase activity. The area has bene®ted from the recent deter- mination of many structures of a-amylases, inhibitors and complexes. These structures highlight the remarkable variety in structural modes of a-amylase inhibition. The continuing discovery of new classes of a-amylase inhibitor ensures that exciting discoveries remain to be made. In this review, we summarize existing knowledge of insect a-am- ylases, plant a-amylase inhibitors and their interaction. Positive results recently obtained for transgenic plants and future prospects in the area are reviewed.
dc.description.version.pt_BR.fl_txt_mv Sim
dc.description.status.pt_BR.fl_txt_mv Publicado
description Insect pests and pathogens (fungi, bacteria and viruses) are responsible for severe crop losses. Insects feed directly on the plant tissues, while the pathogens lead to damage or death of the plant. Plants have evolved a certain degree of resistance through the production of defence compounds, which may be aproteic, e.g. antibiotics, alkaloids, terpenes, cyanogenic glucosides or proteic, e.g. chitinases, b-1,3-glu- canases, lectins, arcelins, vicilins, systemins and enzyme inhibitors. The enzyme inhibitors impede digestion through their action on insect gut digestive a-amylases and pro- teinases, which play a key role in the digestion of plant starch and proteins. The natural defences of crop plants may be improved through the use of transgenic technology. Current research in the area focuses particularly on weevils as these are highly dependent on starch for their energy supply. Six di€erent a-amylase inhibitor classes, lectin-like, knottin-like, cereal-type, Kunitz-like, c-purothionin-like and thaumatin-like could be used in pest control. These classes of inhibitors show remarkable structural variety leading to di€erent modes of inhibition and di€erent speci®city pro®les against diverse a-amylases. Speci®city of inhibition is an important issue as the introduced inhibitor must not adversely a€ect the plant's own a-amylases, nor the nutritional value of the crop. Of particular interest are some bifunctional inhibitors with additional favourable properties, such as proteinase inhibitory activity or chitin- ase activity. The area has bene®ted from the recent deter- mination of many structures of a-amylases, inhibitors and complexes. These structures highlight the remarkable variety in structural modes of a-amylase inhibition. The continuing discovery of new classes of a-amylase inhibitor ensures that exciting discoveries remain to be made. In this review, we summarize existing knowledge of insect a-am- ylases, plant a-amylase inhibitors and their interaction. Positive results recently obtained for transgenic plants and future prospects in the area are reviewed.
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2016-10-10T03:52:14Z
dc.date.available.fl_str_mv 2016-10-10T03:52:14Z
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dc.identifier.citation.fl_str_mv FRANCO, Octávio L. Plant a-amylase inhibitors and their interaction with insect a-amylases Structure, function and potential for crop protection. Eur. J. Biochem. v. 269, p. 397- 412, 2002.
dc.identifier.uri.fl_str_mv http://twingo.ucb.br:8080/jspui/handle/10869/538
https://repositorio.ucb.br:9443/jspui/handle/123456789/7654
identifier_str_mv FRANCO, Octávio L. Plant a-amylase inhibitors and their interaction with insect a-amylases Structure, function and potential for crop protection. Eur. J. Biochem. v. 269, p. 397- 412, 2002.
url http://twingo.ucb.br:8080/jspui/handle/10869/538
https://repositorio.ucb.br:9443/jspui/handle/123456789/7654
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