Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas

Detalhes bibliográficos
Autor(a) principal: Barros, Edilberto dos Santos
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UCB
Texto Completo: https://bdtd.ucb.br:8443/jspui/handle/tede/2188
Resumo: Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile.
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spelling C??rdova, Cl??udio Olavo de Almeidahttp://lattes.cnpq.br/2523362001761091http://lattes.cnpq.br/7403445973350219Barros, Edilberto dos Santos2017-07-05T14:44:39Z2012-04-17BARROS, Edilberto dos Santos. Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas. 2012. 54 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2012.https://bdtd.ucb.br:8443/jspui/handle/tede/2188Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile.Introdu????o: O n??mero de pessoas idosas (60 anos ou mais) cresce em todo o mundo, por dois motivos: aumento da expectativa de vida e redu????o das taxas de fertilidade. Por outro lado, as doen??as cardiovasculares, particularmente a aterosclerose, s??o a maior causa de morte, especialmente na popula????o idosa. O envelhecimento provoca altera????es no sistema imunol??gico que contribuem para uma maior incid??ncia de doen??as infecciosas e cr??nicodegenerativas. N??veis basais de citocinas aumentados, representam um estado inflamat??rio cr??nico sist??mico, chamado de Inflammaging. Na pessoa idosa, a redistribui????o da calcifica????o nos tecidos ?? distinta dos valores preditivos da calcifica????o das art??rias coron??rias. Desta forma, a associa????o de comorbidades provocadas pelo envelhecimento inviabiliza a extrapola????o dos conhecimentos adquiridos em popula????es mais jovens. Objetivo: investigar a associa????o entre n??veis s??ricos das citocinas: TNF- , IL-10 e Prote??na C Reativa (PCR) com a calcifica????o coronariana em pessoas muito idosas. Materiais e m??todos: Indiv??duos com idade entre 80 e 102 anos (n = 178). Foram avaliadas citocinas plasm??ticas, prote??nas de fase aguda, espessura ??ntima-m??dia (IMT), presen??a de placas nas art??rias car??tidas por ultrassom e calcifica????o da art??ria coron??ria (CAC) por tomografia computadorizada. Resultados: N??o houve associa????o entre CAC e placas carot??deas (p = 0,8), m??ximo (p = 0,06) ou m??dia IMT (p = 0,2). N??o foi encontrada associa????o entre a presen??a de placas carot??deas e PCR (p = 0,4), TNF- (p = 0,8) ou IL-10 (p = 0,2). Da mesma forma, os indiv??duos nos tr??s primeiros quartis de PCR, TNF- ou valores de IL-10 an??ncios similares de CAC e IMT m??ximo. Os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75. Conclus??o: Em indiv??duos muito idosos, os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75.Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-07-05T14:44:28Z No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5)Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-07-05T14:44:39Z (GMT) No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5)Made available in DSpace on 2017-07-05T14:44:39Z (GMT). No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5) Previous issue date: 2012-04-17application/pdfhttps://bdtd.ucb.br:8443/jspui/retrieve/4787/EdilbertodosSantosBarrosDissertacacao2012.pdf.jpgporUniversidade Cat??lica de Bras??liaPrograma Strictu Sensu em Educa????o F??sicaUCBBrasilEscola de Sa??de e MedicinaInflama????oAteroscleroseEnvelhecimentoDoen??a coron??riaCNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICAAssocia????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UCBinstname:Universidade Católica de Brasília (UCB)instacron:UCBLICENSElicense.txtlicense.txttext/plain; charset=utf-82122https://200.214.135.178:8443/jspui/bitstream/tede/2188/1/license.txt302d2cd6169132532f8ce4ab3974cba3MD51ORIGINALEdilbertodosSantosBarrosDissertacacao2012.pdfEdilbertodosSantosBarrosDissertacacao2012.pdfapplication/pdf1470664https://200.214.135.178:8443/jspui/bitstream/tede/2188/2/EdilbertodosSantosBarrosDissertacacao2012.pdfe078323f3716ae1ad3491d28ce8fcfceMD52THUMBNAILEdilbertodosSantosBarrosDissertacacao2012.pdf.jpgEdilbertodosSantosBarrosDissertacacao2012.pdf.jpgimage/jpeg4946https://200.214.135.178:8443/jspui/bitstream/tede/2188/3/EdilbertodosSantosBarrosDissertacacao2012.pdf.jpg45b3714f17f93e736dad2fa2725a81bfMD53tede/21882019-09-09 17:29:50.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Biblioteca Digital de Teses e Dissertaçõeshttps://bdtd.ucb.br:8443/jspui/
dc.title.por.fl_str_mv Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
title Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
spellingShingle Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
Barros, Edilberto dos Santos
Inflama????o
Aterosclerose
Envelhecimento
Doen??a coron??ria
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
title_short Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
title_full Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
title_fullStr Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
title_full_unstemmed Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
title_sort Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas
author Barros, Edilberto dos Santos
author_facet Barros, Edilberto dos Santos
author_role author
dc.contributor.advisor1.fl_str_mv C??rdova, Cl??udio Olavo de Almeida
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2523362001761091
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7403445973350219
dc.contributor.author.fl_str_mv Barros, Edilberto dos Santos
contributor_str_mv C??rdova, Cl??udio Olavo de Almeida
dc.subject.por.fl_str_mv Inflama????o
Aterosclerose
Envelhecimento
Doen??a coron??ria
topic Inflama????o
Aterosclerose
Envelhecimento
Doen??a coron??ria
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
dc.description.abstract.eng.fl_txt_mv Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile.
dc.description.abstract.por.fl_txt_mv Introdu????o: O n??mero de pessoas idosas (60 anos ou mais) cresce em todo o mundo, por dois motivos: aumento da expectativa de vida e redu????o das taxas de fertilidade. Por outro lado, as doen??as cardiovasculares, particularmente a aterosclerose, s??o a maior causa de morte, especialmente na popula????o idosa. O envelhecimento provoca altera????es no sistema imunol??gico que contribuem para uma maior incid??ncia de doen??as infecciosas e cr??nicodegenerativas. N??veis basais de citocinas aumentados, representam um estado inflamat??rio cr??nico sist??mico, chamado de Inflammaging. Na pessoa idosa, a redistribui????o da calcifica????o nos tecidos ?? distinta dos valores preditivos da calcifica????o das art??rias coron??rias. Desta forma, a associa????o de comorbidades provocadas pelo envelhecimento inviabiliza a extrapola????o dos conhecimentos adquiridos em popula????es mais jovens. Objetivo: investigar a associa????o entre n??veis s??ricos das citocinas: TNF- , IL-10 e Prote??na C Reativa (PCR) com a calcifica????o coronariana em pessoas muito idosas. Materiais e m??todos: Indiv??duos com idade entre 80 e 102 anos (n = 178). Foram avaliadas citocinas plasm??ticas, prote??nas de fase aguda, espessura ??ntima-m??dia (IMT), presen??a de placas nas art??rias car??tidas por ultrassom e calcifica????o da art??ria coron??ria (CAC) por tomografia computadorizada. Resultados: N??o houve associa????o entre CAC e placas carot??deas (p = 0,8), m??ximo (p = 0,06) ou m??dia IMT (p = 0,2). N??o foi encontrada associa????o entre a presen??a de placas carot??deas e PCR (p = 0,4), TNF- (p = 0,8) ou IL-10 (p = 0,2). Da mesma forma, os indiv??duos nos tr??s primeiros quartis de PCR, TNF- ou valores de IL-10 an??ncios similares de CAC e IMT m??ximo. Os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75. Conclus??o: Em indiv??duos muito idosos, os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75.
description Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile.
publishDate 2012
dc.date.issued.fl_str_mv 2012-04-17
dc.date.accessioned.fl_str_mv 2017-07-05T14:44:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
format masterThesis
dc.identifier.citation.fl_str_mv BARROS, Edilberto dos Santos. Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas. 2012. 54 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2012.
dc.identifier.uri.fl_str_mv https://bdtd.ucb.br:8443/jspui/handle/tede/2188
identifier_str_mv BARROS, Edilberto dos Santos. Associa????o entre n??veis s??ricos de mediadores inflamat??rios e aspectos da doen??a coronariana subcl??nica em pessoas muito idosas. 2012. 54 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2012.
url https://bdtd.ucb.br:8443/jspui/handle/tede/2188
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Cat??lica de Bras??lia
dc.publisher.program.fl_str_mv Programa Strictu Sensu em Educa????o F??sica
dc.publisher.initials.fl_str_mv UCB
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Escola de Sa??de e Medicina
publisher.none.fl_str_mv Universidade Cat??lica de Bras??lia
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UCB
instname:Universidade Católica de Brasília (UCB)
instacron:UCB
instname_str Universidade Católica de Brasília (UCB)
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