AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/680 |
Resumo: | Diabetes mellitus (DM) is a disease that is increasingly affecting the world's population, characterized by abnormal elevation of glucose levels in the blood, results from defects in insulin secretion or in its action on the body. Surveys show a DM epidemic in progress, designing a number worldwide of 471 million people with the disease in 2035. In the search for new treatment alternatives, some polysaccharides derived from plants, algae, bacteria and fungi aroused interest of the chemical and pharmaceutical, and various research groups in countries around the world. Among the polysaccharides of interest, there are the β-glucans, which have demonstrated biological effects, especially in the treatment of diabetes. However, its low solubility hinders its use for therapeutic purposes, with the necessity of chemical modification of the molecule, improving negative aspect of this low solubility. The chemical modifications in the structure of glucan to carboxymethylation, has contributed to increase the solubility of the molecule, so favoring specific tests on different models of disease. The aim of this study was to test on a model of diabetic animals, the hypoglycemic effect of - (1 → 6) -D-glucan chemically modified by carboxymethylation. 30 Wistar rats were used, with 110 days old and 266 ± 15 g. of weight. The induction of diabetes was performed by administering Aloxan Monohydrate at a concentration of 125 mg / kg animal body weight. In sub-chronic form, the animal groups received 5 and 15 mg / kg - (1 → 6) -D-glucana produced the fungus in submerged culture Lasiodiplodia theobromae MMPI chemically modified by carboxymethylation, 15 mg / kg of metformin, in addition saline for the control groups. Their term of treatment was 28 days and this period monitored weekly weight, glucose levels and daily feed intake and water. At the end of treatment, animals were anesthetized for blood collection and later sacrificed for removal of organs. They were performed biochemical analyzes quantifying cholesterol levels, triglycerides, SGOT, SGPT, urea, creatinine and glucose in addition to histological evaluation of the kidneys, the pancreas and liver of animals. |
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MALFATTI, CARLOS RICARDO MANECKhttp://lattes.cnpq.br/7879558601666787SILVA, WEBER CLÁUDIO FRANCISCO NUNES DAhttp://lattes.cnpq.br/1892865713778963073.341.039-12http://lattes.cnpq.br/3104205543670185SNAK, ANDRÉ LUIZ2017-06-07T17:30:43Z2016-09-02SNAK, ANDRÉ LUIZ. AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES. 2016. 47 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR.http://tede.unicentro.br:8080/jspui/handle/jspui/680Diabetes mellitus (DM) is a disease that is increasingly affecting the world's population, characterized by abnormal elevation of glucose levels in the blood, results from defects in insulin secretion or in its action on the body. Surveys show a DM epidemic in progress, designing a number worldwide of 471 million people with the disease in 2035. In the search for new treatment alternatives, some polysaccharides derived from plants, algae, bacteria and fungi aroused interest of the chemical and pharmaceutical, and various research groups in countries around the world. Among the polysaccharides of interest, there are the β-glucans, which have demonstrated biological effects, especially in the treatment of diabetes. However, its low solubility hinders its use for therapeutic purposes, with the necessity of chemical modification of the molecule, improving negative aspect of this low solubility. The chemical modifications in the structure of glucan to carboxymethylation, has contributed to increase the solubility of the molecule, so favoring specific tests on different models of disease. The aim of this study was to test on a model of diabetic animals, the hypoglycemic effect of - (1 → 6) -D-glucan chemically modified by carboxymethylation. 30 Wistar rats were used, with 110 days old and 266 ± 15 g. of weight. The induction of diabetes was performed by administering Aloxan Monohydrate at a concentration of 125 mg / kg animal body weight. In sub-chronic form, the animal groups received 5 and 15 mg / kg - (1 → 6) -D-glucana produced the fungus in submerged culture Lasiodiplodia theobromae MMPI chemically modified by carboxymethylation, 15 mg / kg of metformin, in addition saline for the control groups. Their term of treatment was 28 days and this period monitored weekly weight, glucose levels and daily feed intake and water. At the end of treatment, animals were anesthetized for blood collection and later sacrificed for removal of organs. They were performed biochemical analyzes quantifying cholesterol levels, triglycerides, SGOT, SGPT, urea, creatinine and glucose in addition to histological evaluation of the kidneys, the pancreas and liver of animals.O diabetes mellitus (DM) é uma doença que vem crescentemente afetando a população mundial, caracterizada pela elevação anormal dos níveis de glicose no sangue, resulta de defeitos na secreção de insulina ou na sua ação sobre o organismo. Levantamentos realizados demonstram uma epidemia de DM em curso, projetando um número a nível mundial de 471 milhões de portadores da doença em 2035. Na busca de novas alternativas de tratamento, alguns polissacarídeos oriundos de plantas, algas, bactérias e fungos despertaram interesse de indústrias químicas e farmacêuticas, e de diversos grupos de pesquisas em vários países do mundo. Dentre os polissacarídeos de interesse, destacam-se as β-glucanas, as quais apresentam efeitos biológicos comprovados, principalmente no tratamento do DM. Porém, sua baixa solubilidade dificulta o seu uso com fins terapêuticos, havendo a necessidade da modificação química da molécula, melhorando esse aspecto negativo da baixa solubilidade. As modificações químicas na estrutura das glucanas por carboximetilação têm contribuído para aumentar a solubilidade da molécula, favorecendo então testes específicos sobre diferentes modelos de doenças. O objetivo deste estudo foi testar sobre um modelo de animais diabéticos, o efeito hipoglicemiante da -(1→6)-D-glucana modificada quimicamente por carboximetilação. Foram utilizados 30 ratos wistar machos, com 110 dias de idade e 266 ± 15 g. de peso. A indução do diabetes foi realizada pela administração de Aloxan Monohidratado, na concentração de 125 mg/kg peso animal. De forma sub-crônica, os grupos de animais receberam 5 e 15 mg/kg de -(1→6)-D-glucana produzida pelo fungo Lasiodiplodia theobromae MMPI em cultivo submerso, modificada quimicamente por carboximetilação, 15 mg/kg de Metformina, além de solução salina para os grupos controle. A duração do respectivo tratamento foi de 28 dias, sendo neste período monitorado semanalmente o peso, níveis glicêmicos e diariamente o consumo de ração e água. Ao final do tratamento, os animais foram anestesiados para coleta sanguínea e posteriormente sacrificados para a retirada de seus órgãos. Foram realizadas análises bioquímicas quantificando os níveis de Colesterol, Triglicerídeos, TGO, TGP, Ureia, Creatinina e Glicose, além da avaliação histológica dos Rins, do Pâncreas e Fígado dos animais.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2017-06-07T17:30:43Z No. of bitstreams: 1 ANDRÉ LUIZ SNAK.pdf: 723145 bytes, checksum: 5250ed85fafb7bf48619ee5b923af535 (MD5)Made available in DSpace on 2017-06-07T17:30:43Z (GMT). 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dc.title.por.fl_str_mv |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
title |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
spellingShingle |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES SNAK, ANDRÉ LUIZ Diabetes carboximetilação e Glicemia Exopolissacarídeo Diabetes carboxymethylation and glycemia Lasiodiplodana exopolysaccharide CIENCIAS DA SAUDE::FARMACIA |
title_short |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
title_full |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
title_fullStr |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
title_full_unstemmed |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
title_sort |
AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES |
author |
SNAK, ANDRÉ LUIZ |
author_facet |
SNAK, ANDRÉ LUIZ |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
MALFATTI, CARLOS RICARDO MANECK |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7879558601666787 |
dc.contributor.advisor-co1.fl_str_mv |
SILVA, WEBER CLÁUDIO FRANCISCO NUNES DA |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/1892865713778963 |
dc.contributor.authorID.fl_str_mv |
073.341.039-12 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3104205543670185 |
dc.contributor.author.fl_str_mv |
SNAK, ANDRÉ LUIZ |
contributor_str_mv |
MALFATTI, CARLOS RICARDO MANECK SILVA, WEBER CLÁUDIO FRANCISCO NUNES DA |
dc.subject.por.fl_str_mv |
Diabetes carboximetilação e Glicemia Exopolissacarídeo |
topic |
Diabetes carboximetilação e Glicemia Exopolissacarídeo Diabetes carboxymethylation and glycemia Lasiodiplodana exopolysaccharide CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Diabetes carboxymethylation and glycemia Lasiodiplodana exopolysaccharide |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Diabetes mellitus (DM) is a disease that is increasingly affecting the world's population, characterized by abnormal elevation of glucose levels in the blood, results from defects in insulin secretion or in its action on the body. Surveys show a DM epidemic in progress, designing a number worldwide of 471 million people with the disease in 2035. In the search for new treatment alternatives, some polysaccharides derived from plants, algae, bacteria and fungi aroused interest of the chemical and pharmaceutical, and various research groups in countries around the world. Among the polysaccharides of interest, there are the β-glucans, which have demonstrated biological effects, especially in the treatment of diabetes. However, its low solubility hinders its use for therapeutic purposes, with the necessity of chemical modification of the molecule, improving negative aspect of this low solubility. The chemical modifications in the structure of glucan to carboxymethylation, has contributed to increase the solubility of the molecule, so favoring specific tests on different models of disease. The aim of this study was to test on a model of diabetic animals, the hypoglycemic effect of - (1 → 6) -D-glucan chemically modified by carboxymethylation. 30 Wistar rats were used, with 110 days old and 266 ± 15 g. of weight. The induction of diabetes was performed by administering Aloxan Monohydrate at a concentration of 125 mg / kg animal body weight. In sub-chronic form, the animal groups received 5 and 15 mg / kg - (1 → 6) -D-glucana produced the fungus in submerged culture Lasiodiplodia theobromae MMPI chemically modified by carboxymethylation, 15 mg / kg of metformin, in addition saline for the control groups. Their term of treatment was 28 days and this period monitored weekly weight, glucose levels and daily feed intake and water. At the end of treatment, animals were anesthetized for blood collection and later sacrificed for removal of organs. They were performed biochemical analyzes quantifying cholesterol levels, triglycerides, SGOT, SGPT, urea, creatinine and glucose in addition to histological evaluation of the kidneys, the pancreas and liver of animals. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-09-02 |
dc.date.accessioned.fl_str_mv |
2017-06-07T17:30:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SNAK, ANDRÉ LUIZ. AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES. 2016. 47 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/680 |
identifier_str_mv |
SNAK, ANDRÉ LUIZ. AVALIAÇÃO DA RESPOSTA BIOLÓGICA DA LASIODIPLODANA MODIFICADA QUIMICAMENTE POR CARBOXIMETILAÇÃO SOBRE UM MODELO ANIMAL DE DIABETES. 2016. 47 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/680 |
dc.language.iso.fl_str_mv |
por |
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por |
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info:eu-repo/semantics/openAccess |
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Universidade Estadual do Centro-Oeste |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Farmácia |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
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bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UNICENTRO - Universidade Estadual do Centro-Oeste (UNICENTRO) |
repository.mail.fl_str_mv |
repositorio@unicentro.br||fabianoqueiroz@yahoo.com.br |
_version_ |
1811733811446153216 |